Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4)

Restricted Expression:

lung [show more like this]

germ cell tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

lung; uncharacterized tissue; mixed; testis; brain; heart

NCBI

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UGID:140990 UniGene Hs.86941 Homo sapiens (human) HCN4

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Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4)

Human protein-coding gene HCN4. Represented by 42 ESTs from 15 cDNA libraries. EST representation biased toward lung; germ cell tumor. Corresponds to reference sequence NM_005477.2. [UniGene 140990 - Hs.86941]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_005468.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	HCN4 gene product	H. sapiens	100.0	1202
NP_001074661.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Hcn4 gene product	M. musculus	95.2	1200
XP_686078.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	D. rerio	67.9	1068
NP_001033946.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	I[[h]] channel, isoform I	D. melanogaster	63.0	516
Other hits (2 of 38) [Show all]		Species	Id(%)	Len(aa)
XP_002804905.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4-like, partial	M. mulatta	99.4	980
XP_003952750.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	P. troglodytes	96.5	1185

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	15
Map position:	15q24.1
UniSTS entry:	Chr 15	RH92735
UniSTS entry:	Chr 15	PMC155041P2

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (4)

AJ132429.1	Homo sapiens mRNA for hyperpolarization-activated cyclic nucleotide gated cation channel hHCN4	P
AJ238850.1	Homo sapiens mRNA for hyperpolarization-activated channel type 4 (HCN4)	P
NM_005477.2	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA	PA
DQ854814.1	Homo sapiens hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 mRNA, 5' UTR

EST sequences (10 of 42) [Show all sequences]

AA969962.1	Clone IMAGE:1581239	mixed	3' read	A
AA995375.1	Clone IMAGE:1601584	lung	3' read
AA902394.1	Clone IMAGE:1519314	uncharacterized tissue	3' read
BX090501.1	Clone IMAGp998N193846_;_IMAGE:1519314	uncharacterized tissue		A
AI273647.1	Clone IMAGE:1876836	mixed	3' read	A
AI350399.1	Clone IMAGE:1947819	uncharacterized tissue	3' read
AI458708.1	Clone IMAGE:2150942	lung	3' read
AI671859.1	Clone IMAGE:2307603	uncharacterized tissue	3' read
AI702698.1	Clone IMAGE:2340254	lung	3' read
AI638000.1	Clone IMAGE:2242327	uncharacterized tissue	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria