> Matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
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UGID:140712     UniGene Hs.83169     Homo sapiens (human)   MMP1 Order cDNA clone, Links
Matrix metallopeptidase 1 (interstitial collagenase) (MMP1)

Human protein-coding gene MMP1. Represented by 3297 ESTs from 105 cDNA libraries. EST representation biased toward neonate. Corresponds to 2 reference sequences (different isoforms). [UniGene 140712 - Hs.83169]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002412.1 MMP1 gene product H. sapiens 100.0 468
XP_508722.2 PREDICTED: interstitial collagenase isoform 3 P. troglodytes 99.8 468
NP_001088423.1 matrix metalloproteinase-18 precursor X. laevis 64.9 466
NP_114395.1 Mmp1a gene product M. musculus 64.9 463
XP_001345507.1 PREDICTED: collagenase 3 D. rerio 54.8 459
NP_001189004.1 matrix metalloproteinase 1, isoform J D. melanogaster 50.9 226
NP_503790.1 Protein C31B8.8 C. elegans 45.6 206
Other hits (2 of 39) [Show all]SpeciesId(%)Len(aa)
XP_001098302.1 PREDICTED: interstitial collagenase isoform 2 M. mulatta 98.3 468
XP_003910651.1 PREDICTED: interstitial collagenase-like isoform 1 P. anubis 98.1 468

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: vascular; connective tissue; thyroid; skin; lung; umbilical cord; esophagus; uncharacterized tissue; placenta; intestine; stomach; blood; embryonic tissue; mixed; uterus; pancreas; brain; muscle; kidney; eye; larynx; ovary; liver; bone; bladder
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11q22.3
UniSTS entry: Chr 11 SHGC-82595
UniSTS entry: Chr 11 MMP1
UniSTS entry: Chr 11 G54104
UniSTS entry: Chr 11 RH17661
UniSTS entry: Chr 11 SHGC-11954 [Map Viewer]
UniSTS entry: Chr 11 PMC151710P4
UniSTS entry: Chr 11 PMC65699P1
UniSTS entry: Chr 11 PMC125702P5
UniSTS entry: Chr 11 MMP1 [Map Viewer]
UniSTS entry: Chr 11 MMP1_3098
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (22)

BT006874.1 Homo sapiens matrix metalloproteinase 1 (interstitial collagenase) mRNA, complete cds P
AK130687.1 Homo sapiens cDNA FLJ27177 fis, clone SYN02037, highly similar to Interstitial collagenase precursor (EC 3.4.24.7) P
NM_002421.3 Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1, mRNA PA
BT020147.1 Homo sapiens matrix metalloproteinase 1 (interstitial collagenase) mRNA, complete cds P
AK223281.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: SYN05257 P
AK223056.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: JTH13338 PA
AK223036.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: JTH05414 PA
AK223035.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: JTH06843 P
AK223034.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: JTH04784 PA
AK024818.1 Homo sapiens cDNA: FLJ21165 fis, clone CAS10833, highly similar to HSCOLL1 Homo sapiens mRNA for type I interstitial collagenase PA
AK225495.1 Homo sapiens mRNA for matrix metalloproteinase 1 preproprotein variant, clone: JTH10996 PA
DQ399597.1 Homo sapiens matrix metalloproteinase 1 (MMP1) mRNA, partial cds
BC013875.2 Homo sapiens matrix metallopeptidase 1 (interstitial collagenase), mRNA (cDNA clone MGC:10479 IMAGE:3834572), complete cds PA
BC013118.1 Homo sapiens matrix metallopeptidase 1 (interstitial collagenase), mRNA (cDNA clone IMAGE:3863095), partial cds PA
X05231.1 Human mRNA for collagenase (E.C. 3.4.24) P
X54925.1 H.sapiens mRNA for type I interstitial collagenase P
AK098450.1 Homo sapiens cDNA FLJ25584 fis, clone JTH09843, highly similar to INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) P
AK301340.1 Homo sapiens cDNA FLJ54761 complete cds, highly similar to Interstitial collagenase precursor (EC 3.4.24.7) PA
AK297723.1 Homo sapiens cDNA FLJ55228 complete cds, highly similar to Interstitial collagenase precursor (EC 3.4.24.7) P
M15996.1 Human synovial cell collagenase mRNA
NM_001145938.1 Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 2, mRNA PA
M13509.1 Human skin collagenase mRNA, complete cds P

EST sequences (10 of 3297) [Show all sequences]

AI037890.1 Clone IMAGE:1664711 skin 3' read A
AI038497.1 Clone IMAGE:1658571 embryonic tissue 3' read A
AI076956.1 Clone IMAGE:1666828 skin 3' read A
AI081490.1 Clone IMAGE:1679090 skin 3' read A
AI082493.1 Clone IMAGE:1660208 embryonic tissue 3' read A
AI147810.1 Clone IMAGE:1666681 skin 3' read A
AI085755.1 Clone IMAGE:1681217 skin 3' read A
BX100055.1 Clone IMAGp998M19736 skin 5' read P
AI270203.1 Clone IMAGE:1962754 intestine 3' read A
AI282835.1 Clone IMAGE:1960721 esophagus 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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