> MAP-kinase activating death domain (MADD)
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UGID:140658     UniGene Hs.82548     Homo sapiens (human)   MADD Order cDNA clone, Links
MAP-kinase activating death domain (MADD)

Human protein-coding gene MADD. Represented by 464 ESTs from 231 cDNA libraries. Corresponds to 10 reference sequences (different isoforms). [UniGene 140658 - Hs.82548]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_003673.3 MADD gene product H. sapiens 100.0 1646
XP_003951918.1 PREDICTED: LOW QUALITY PROTEIN: MAP kinase-activating death domain protein P. troglodytes 99.9 1646
NP_001171191.1 MAP kinase-activating death domain protein isoform 11 M. musculus 97.6 1626
XP_001923990.1 PREDICTED: MAP kinase-activating death domain protein isoform 3 D. rerio 84.3 1659
NP_001245676.1 rab3-GEF, isoform F D. melanogaster 57.2 1785
NP_741710.1 Protein AEX-3, isoform a C. elegans 56.8 1271
Other hits (2 of 31) [Show all]SpeciesId(%)Len(aa)
XP_003909987.1 PREDICTED: MAP kinase-activating death domain protein isoform 9 P. anubis 99.5 1646
XP_001107325.1 PREDICTED: MAP kinase-activating death domain protein-like isoform 1 M. mulatta 99.4 1646

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; uncharacterized tissue; eye; intestine; muscle; skin; lung; placenta; mixed; pancreas; prostate; kidney; stomach; ovary; uterus; connective tissue; adrenal gland; pharynx; vascular; spleen; embryonic tissue; nerve; thymus; trachea; blood; umbilical cord; bladder; tonsil; thyroid; ascites; bone; lymph node; mammary gland; mouth; cervix; pituitary gland; liver; ear; bone marrow; heart; pineal gland; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p11.2
UniSTS entry: Chr 11 WI-20765 [Map Viewer]
UniSTS entry: Chr 11 RH76662
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (20)

NM_003682.3 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 4, mRNA PA
AF440434.1 Homo sapiens insulinoma-glucagonoma protein 20 splice variant 4 (IG20) mRNA, complete cds P
AF440103.1 Homo sapiens insulinoma-glucagonoma protein 20 splice variant 3 (IG20) mRNA, complete cds, alternatively spliced P
AF440102.1 Homo sapiens insulinoma-glucagonoma protein 20 splice variant 2 (IG20) mRNA, complete cds, alternatively spliced P
AF440101.1 Homo sapiens insulinoma-glucagonoma protein 20 pro-apoptotic splice variant (IG20) mRNA, complete cds, alternatively spliced P
AF440100.1 Homo sapiens insulinoma-glucagonoma protein 20 (IG20) mRNA, complete cds P
AK292442.1 Homo sapiens cDNA FLJ78759 complete cds, highly similar to Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 3, mRNA P
U44953.1 Homo sapiens DENN mRNA, complete cds PA
NM_130476.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 8, mRNA PA
NM_130475.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 7, mRNA PA
NM_130474.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 6, mRNA PA
NM_130473.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 5, mRNA PA
NM_130472.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 3, mRNA PA
NM_130471.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 2, mRNA PA
NM_130470.2 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 1, mRNA PA
NM_001135944.1 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 10, mRNA PA
NM_001135943.1 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 9, mRNA PA
BC040484.1 Homo sapiens MAP-kinase activating death domain, mRNA (cDNA clone MGC:33145 IMAGE:5271798), complete cds PA
U77352.1 Homo sapiens MAP kinase-activating death domain protein (MADD) mRNA, complete cds PA
AB002356.1 Homo sapiens mRNA for KIAA0358 gene, partial cds P

EST sequences (10 of 464) [Show all sequences]

AA977255.1 Clone IMAGE:1558805 lung 3' read P
AA994656.1 Clone IMAGE:1626641 mixed 3' read P
AA911714.1 Clone IMAGE:1521084 lung 3' read A
AI004679.1 Clone IMAGE:1632099 mammary gland 3' read A
AI075202.1 Clone IMAGE:1673671 mixed 3' read A
AI095131.1 Clone IMAGE:1687220 brain 3' read A
AI125825.1 Clone IMAGE:1737322 testis 3' read
CB164318.1 Clone L17N670205n1-39-C11 liver 5' read P
R31309.1 Clone IMAGE:135635 placenta 5' read
CB115976.1 Clone L8SCK0-11-H01 liver 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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