Uncoupling protein 2 (mitochondrial, proton carrier) (UCP2)

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UGID:140481 UniGene Hs.80658 Homo sapiens (human) UCP2

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Uncoupling protein 2 (mitochondrial, proton carrier) (UCP2)

Human protein-coding gene UCP2. Represented by 629 ESTs from 240 cDNA libraries. Corresponds to reference sequence NM_003355.2. [UniGene 140481 - Hs.80658]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_508635.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mitochondrial uncoupling protein 2 isoform 4	P. troglodytes	100.0	308
NP_003346.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	UCP2 gene product	H. sapiens	100.0	308
NP_035801.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Ucp2 gene product	M. musculus	97.1	308
NP_571251.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	ucp2 gene product	D. rerio	86.7	309
NP_001080223.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	uncoupling protein 2 (mitochondrial, proton carrier)	X. laevis	86.6	306
NP_190979.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	uncoupling mitochondrial protein 1	A. thaliana	53.0	281
XP_001695417.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	uncoupling protein	C. reinhardtii	50.9	295
Other hits (2 of 45) [Show all]		Species	Id(%)	Len(aa)
NP_001182322.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mitochondrial uncoupling protein 2	M. mulatta	99.3	308
NP_001003048.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	UCP2 gene product	C. lupus familiaris	98.7	308

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	uncharacterized tissue; lung; brain; spleen; uterus; blood; thyroid; intestine; heart; cervix; lymph; thymus; mixed; ovary; lymph node; adipose tissue; kidney; mammary gland; bone marrow; placenta; eye; adrenal gland; pituitary gland; larynx; connective tissue; pancreas; trachea; salivary gland; epididymis; tonsil; stomach; embryonic tissue; mouth; prostate; testis; muscle; pharynx; liver; umbilical cord; bladder; skin; ascites; amniotic fluid; bone; vascular

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	11
Map position:	11q13
UniSTS entry:	Chr 11	PMC310777P17
UniSTS entry:	Chr 11	WI-13873	[Map Viewer]
UniSTS entry:	Chr 11	PMC310777P18

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

NM_003355.2	Homo sapiens uncoupling protein 2 (mitochondrial, proton carrier) (UCP2), nuclear gene encoding mitochondrial protein, mRNA	P
AK222557.1	Homo sapiens mRNA for uncoupling protein 2 variant, clone: adSU01813	PA
AK222540.1	Homo sapiens mRNA for uncoupling protein 2 variant, clone: adSE01386	P
AK025742.1	Homo sapiens cDNA: FLJ22089 fis, clone HEP16080, highly similar to HSU94592 Human uncoupling protein homolog (UCPH) mRNA	PA
BC011737.2	Homo sapiens uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds	PA
U82819.1	Homo sapiens UCP2 mRNA, complete cds	P
U94592.1	Human uncoupling protein homolog (UCPH) mRNA, complete cds	P
U76367.1	Human uncoupling protein-2 (UCP2) mRNA, nuclear gene encoding mitochondrial protein, complete cds	P

EST sequences (10 of 629) [Show all sequences]

AA910489.1	Clone IMAGE:1516833	uncharacterized tissue	3' read
AI003419.1	Clone IMAGE:1414829	spleen	3' read
AI143092.1	Clone IMAGE:1705607	heart	3' read
CB054166.1	Clone IMAGE:3291447	brain	3' read	PA
CB054167.1	Clone IMAGE:3291447	brain	5' read	P
CB054998.1	Clone IMAGE:3291706	brain	3' read	PA
CB054999.1	Clone IMAGE:3291706	brain	5' read	P
CB140117.1	Clone L13SNU387-11-E11	liver	5' read
AA897099.1	Clone IMAGE:1425267	spleen	3' read
R34657.1	Clone IMAGE:37129	brain	5' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria