Proprotein convertase subtilisin/kexin type 1 (PCSK1)

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UGID:140292 UniGene Hs.78977 Homo sapiens (human) PCSK1

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Proprotein convertase subtilisin/kexin type 1 (PCSK1)

Human protein-coding gene PCSK1. Represented by 128 ESTs from 48 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 140292 - Hs.78977]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_001134900.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: neuroendocrine convertase 1 isoform 1	P. troglodytes	100.0	752
NP_000430.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PCSK1 gene product	H. sapiens	100.0	752
NP_038656.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Pcsk1 gene product	M. musculus	96.0	752
NP_001131134.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	pcsk1 gene product	D. rerio	82.8	751
NP_492974.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein KPC-1, isoform a	C. elegans	56.8	592
NP_014161.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Kex2p	S. cerevisiae	52.5	196
NP_001079135.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	proprotein convertase subtilisin/kexin type 2 precursor	X. laevis	52.2	590
XP_965319.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	hypothetical protein NCU03219	N. crassa	50.5	188
NP_477318.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	amontillado	D. melanogaster	48.8	578
Other hits (2 of 45) [Show all]		Species	Id(%)	Len(aa)
XP_003899990.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: neuroendocrine convertase 1	P. anubis	98.8	748
XP_002804496.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: neuroendocrine convertase 1-like	M. mulatta	98.3	705

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	pancreas; brain; uncharacterized tissue; testis; lung; connective tissue; stomach; mammary gland; pituitary gland; blood; intestine; trachea; kidney; eye; nerve; bone; mixed; ovary

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	5
Map position:	5q15-q21
UniSTS entry:	Chr 5	RH81073
UniSTS entry:	Chr 5	STS-X64810
UniSTS entry:	Chr 5	PCSK1_1012

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

NM_000439.4	Homo sapiens proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 1, mRNA	P
AB208874.1	Homo sapiens mRNA for proprotein convertase subtilisin/kexin type 1 preproprotein variant protein	P
X64810.1	H.sapiens encoding PC1/PC3	P
M90753.1	H.sapiens PC1 (NEC1) mRNA, complete cds	PA
BC130295.1	Homo sapiens proprotein convertase subtilisin/kexin type 1, mRNA (cDNA clone MGC:163167 IMAGE:40146326), complete cds	P
AK308575.1	Homo sapiens cDNA, FLJ98616	P
BC031211.1	Homo sapiens proprotein convertase subtilisin/kexin type 1, mRNA (cDNA clone IMAGE:5275840)	A
AK303888.1	Homo sapiens cDNA FLJ51752 complete cds, highly similar to Neuroendocrine convertase 1 precursor (EC 3.4.21.93)	P
BC136486.1	Homo sapiens proprotein convertase subtilisin/kexin type 1, mRNA (cDNA clone MGC:168098 IMAGE:9020475), complete cds	P
NM_001177876.1	Homo sapiens proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 3, mRNA	P
NM_001177875.1	Homo sapiens proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 2, mRNA	P

EST sequences (10 of 128) [Show all sequences]

AA947930.1	Clone IMAGE:1415999	lung	3' read	A
AA987979.1	Clone IMAGE:1603459	lung	3' read	A
R17394.1	Clone IMAGE:31072	brain	5' read
BX096459.1	Clone IMAGp998G171861_;_IMAGE:756904	ovary
BX097162.1	Clone IMAGp998J13150_;_IMAGE:31072	brain		A
AI298534.1	Clone IMAGE:1897054	lung	3' read	P
R42630.1	Clone IMAGE:31072	brain	3' read	A
AU279570.1	Clone CHONS2000415	connective tissue	5' read	P
AU279646.1	Clone CHONS2000847	connective tissue	5' read	P
AI802516.1	Clone IMAGE:2187231	stomach	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria