Mediator complex subunit 22 (MED22)

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UGID:140207 UniGene Hs.78354 Homo sapiens (human) MED22

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Mediator complex subunit 22 (MED22)

Human protein-coding gene MED22. Represented by 382 ESTs from 149 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 140207 - Hs.78354]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_001101391.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 22-like isoform 1	M. mulatta	100.0	199
XP_003911197.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 22	P. anubis	100.0	199
NP_598395.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	MED22 gene product	H. sapiens	100.0	199
XP_528453.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 22 isoform 2	P. troglodytes	99.5	199
NP_001029080.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Med22 gene product	M. musculus	99.0	199
NP_001002144.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	med22 gene product	D. rerio	92.1	139
NP_001085498.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator of RNA polymerase II transcription subunit 22	X. laevis	88.6	200
NP_569870.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator complex subunit 22	D. melanogaster	66.4	133
Other hits (2 of 31) [Show all]		Species	Id(%)	Len(aa)
XP_001498048.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 22-like	E. caballus	99.0	199
NP_001071147.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Med22 gene product	R. norvegicus	99.0	199

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; uncharacterized tissue; testis; uterus; skin; mouth; connective tissue; spleen; thymus; trachea; eye; heart; placenta; mammary gland; lymph node; lung; adrenal gland; muscle; embryonic tissue; prostate; lymph; cervix; intestine; pancreas; kidney; ovary; bone marrow; ascites; mixed; stomach; blood; vascular; salivary gland; adipose tissue; ganglia

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	9
Map position:	9q34.2
UniSTS entry:	Chr 9	D9S1772
UniSTS entry:	Chr 9	RH91137
UniSTS entry:	Chr 9	RH66808
UniSTS entry:	Chr 1	D11S2560
UniSTS entry:	Chr 9	SURF5_8662
UniSTS entry:	Chr 1	D15S1477
UniSTS entry:	Chr 4	D9S1310

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

AJ224359.1	Homo sapiens surf5b mRNA, clone L5	PA
AJ224360.1	Homo sapiens surf5c mRNA, clone 10.9	A
NM_181491.1	Homo sapiens mediator complex subunit 22 (MED22), transcript variant c, mRNA	PA
AK126069.1	Homo sapiens cDNA FLJ44081 fis, clone TESTI4040363, highly similar to Surfeit locus protein 5	P
AK124518.1	Homo sapiens cDNA FLJ42527 fis, clone BRACE3001754, highly similar to Surfeit locus protein 5	P
NM_133640.3	Homo sapiens mediator complex subunit 22 (MED22), transcript variant b, mRNA	PA
BC024225.2	Homo sapiens mediator complex subunit 22, mRNA (cDNA clone MGC:2563 IMAGE:3009749), complete cds	PA
X85178.1	H.sapiens mRNA for SURF-5 protein	P
BC040111.1	Homo sapiens mediator complex subunit 22, mRNA (cDNA clone MGC:48682 IMAGE:6056006), complete cds	PA

EST sequences (10 of 382) [Show all sequences]

T05649.1	Clone HFBDD74	brain
AI126664.1	Clone IMAGE:1713199	uterus	3' read	A
BX118147.1	Clone IMAGp998D16269_;_IMAGE:44794	brain		P
CB134383.1	Clone B1T694954-13-F08	brain	5' read
R37462.1	Clone IMAGE:27263	brain	3' read	A
R46333.1	Clone IMAGE:152335	mammary gland	3' read	A
R46420.1	Clone IMAGE:152335	mammary gland	5' read
R50679.1	Clone IMAGE:153142	mammary gland	5' read
R50680.1	Clone IMAGE:153142	mammary gland	3' read	A
AI569933.1	Clone IMAGE:2222459	pancreas	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria