Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2)

Restricted Expression:

primitive neuroectodermal tumor of the CNS [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

testis; placenta; brain; uncharacterized tissue; nerve; mixed; muscle; larynx; kidney; intestine; prostate; uterus

NCBI

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UGID:140180 UniGene Hs.78036 Homo sapiens (human) SLC6A2

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Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2)

Human protein-coding gene SLC6A2. Represented by 111 ESTs from 35 cDNA libraries. EST representation biased toward primitive neuroectodermal tumor of the CNS. Corresponds to 4 reference sequences (different isoforms). [UniGene 140180 - Hs.78036]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001165975.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	SLC6A2 gene product	H. sapiens	100.0	627
XP_001167725.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: sodium-dependent noradrenaline transporter isoform 6	P. troglodytes	99.8	616
NP_033235.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Slc6a2 gene product	M. musculus	95.6	616
XP_694138.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: sodium-dependent noradrenaline transporter-like	D. rerio	77.6	624
NP_523763.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	dopamine transporter, isoform A	D. melanogaster	61.2	590
NP_499043.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein DAT-1	C. elegans	56.9	571
NP_001083451.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	X. laevis	51.4	539
Other hits (2 of 39) [Show all]		Species	Id(%)	Len(aa)
NP_001028195.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	SLC6A2 gene product	M. mulatta	99.0	616
XP_003916936.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: sodium-dependent noradrenaline transporter	P. anubis	99.0	616

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	16
Map position:	16q12.2
UniSTS entry:	Chr 16	SHGC-61051	[Map Viewer]
UniSTS entry:	Chr 16	D16S3351

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

AB022846.1	Homo sapiens mRNA for norepinephrine transporter isoform 1, partial cds
AB022847.1	Homo sapiens mRNA for norepinephrine transporter isoform 2, partial cds
NM_001043.3	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2), transcript variant 3, mRNA	PA
BC060831.1	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, mRNA (cDNA clone IMAGE:30338878)	PA
M65105.1	Human noradrenaline transporter mRNA, complete cds	P
BC000563.2	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, mRNA (cDNA clone IMAGE:3162672), partial cds	PA
AK310410.1	Homo sapiens cDNA, FLJ17452
AK312793.1	Homo sapiens cDNA, FLJ93211, Homo sapiens solute carrier family 6 (neurotransmitter transporter,noradrenalin), member 2 (SLC6A2), mRNA	P
AK301811.1	Homo sapiens cDNA FLJ58297 complete cds, highly similar to Sodium-dependent noradrenaline transporter	P
NM_001172504.1	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2), transcript variant 1, mRNA	PA
NM_001172502.1	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2), transcript variant 4, mRNA	PA
NM_001172501.1	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2), transcript variant 2, mRNA	PA
BC039309.1	Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, mRNA (cDNA clone IMAGE:5270717), with apparent retained intron	PA

EST sequences (10 of 111) [Show all sequences]

R21411.1	Clone IMAGE:130077	placenta	3' read
R21430.1	Clone IMAGE:130126	placenta	5' read
R21431.1	Clone IMAGE:130126	placenta	3' read
BX117731.1	Clone IMAGp998H17204_;_IMAGE:139840	placenta		PA
R34126.1	Clone IMAGE:136338	placenta	5' read
R34127.1	Clone IMAGE:136338	placenta	3' read
AI247485.1	Clone IMAGE:1848681	mixed	3' read
R36683.1	Clone IMAGE:137257	placenta	3' read
R37527.1	Clone IMAGE:137257	placenta	5' read
AI399889.1	Clone IMAGE:2114008	mixed	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria