> Gamma-glutamyl carboxylase (GGCX)
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UGID:140140     UniGene Hs.77719     Homo sapiens (human)   GGCX Order cDNA clone, Links
Gamma-glutamyl carboxylase (GGCX)

Human protein-coding gene GGCX. Represented by 384 ESTs from 200 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 140140 - Hs.77719]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000812.2 GGCX gene product H. sapiens 100.0 757
XP_515586.2 PREDICTED: vitamin K-dependent gamma-carboxylase isoform 3 P. troglodytes 99.7 757
NP_062776.1 Ggcx gene product M. musculus 95.0 756
NP_001086044.1 gamma-glutamyl carboxylase X. laevis 77.7 722
XP_003199342.1 PREDICTED: vitamin K-dependent gamma-carboxylase-like, partial D. rerio 74.9 447
NP_523885.2 gamma-glutamyl carboxylase, isoform A D. melanogaster 49.0 509
Other hits (2 of 32) [Show all]SpeciesId(%)Len(aa)
XP_001086474.1 PREDICTED: vitamin K-dependent gamma-carboxylase isoform 2 M. mulatta 99.3 757
XP_003908955.1 PREDICTED: vitamin K-dependent gamma-carboxylase isoform 1 P. anubis 99.1 757

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; placenta; testis; embryonic tissue; mouth; lung; uncharacterized tissue; kidney; heart; liver; mixed; skin; vascular; connective tissue; blood; stomach; ovary; adrenal gland; intestine; cervix; eye; mammary gland; uterus; pancreas; muscle; larynx; prostate; thymus; trachea; bone; lymph node; esophagus; pharynx; parathyroid; spleen; bone marrow; thyroid; ascites; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2p12
UniSTS entry: Chr 3 D3S3930
UniSTS entry: Chr 2 RH75358
UniSTS entry: Chr 2 WI-17445 [Map Viewer]
UniSTS entry: Chr 2 G28262
UniSTS entry: Chr 1 GDB:434012
UniSTS entry: Chr 1 D1S1423
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

AK130139.1 Homo sapiens cDNA FLJ26629 fis, clone MPC05371, highly similar to Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) P
NM_000821.5 Homo sapiens gamma-glutamyl carboxylase (GGCX), transcript variant 1, mRNA PA
AK222827.1 Homo sapiens mRNA for gamma-glutamyl carboxylase variant, clone: HEP04834 P
M81592.1 Human gamma-glutamyl carboxylase (hGC) mRNA, complete cds PA
AK225663.1 Homo sapiens mRNA for Vitamin K-dependent gamma-carboxylase variant, clone: STM05092 P
L17128.1 Homo sapiens (clone H4/H16) gamma-glutamic carboxylase mRNA, complete cds P
BC013979.2 Homo sapiens gamma-glutamyl carboxylase, mRNA (cDNA clone MGC:19580 IMAGE:4129593), complete cds PA
AK054569.1 Homo sapiens cDNA FLJ30007 fis, clone 3NB692000012
AK313126.1 Homo sapiens cDNA, FLJ93613, highly similar to Homo sapiens gamma-glutamyl carboxylase (GGCX), mRNA P
AK310483.1 Homo sapiens cDNA, FLJ17525 P
AK297397.1 Homo sapiens cDNA FLJ53359 complete cds, highly similar to Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) P
AK298982.1 Homo sapiens cDNA FLJ53640 complete cds, highly similar to Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) P
EU847509.1 Homo sapiens gamma-glutymyl carboxylase mRNA, complete cds P
BC004422.1 Homo sapiens cDNA clone IMAGE:3352259, containing frame-shift errors PA
NM_001142269.2 Homo sapiens gamma-glutamyl carboxylase (GGCX), transcript variant 2, mRNA PA

EST sequences (10 of 384) [Show all sequences]

AI022338.1 Clone IMAGE:1654558 mixed 3' read A
AI051429.1 Clone IMAGE:1659042 embryonic tissue 3' read A
AI050808.1 Clone IMAGE:1637089 kidney 3' read PA
AI080119.1 Clone IMAGE:1677418 mixed 3' read
AI092257.1 Clone IMAGE:1683280 parathyroid 3' read A
AI091824.1 Clone IMAGE:1690950 mixed 3' read
AI123873.1 Clone IMAGE:1692888 heart 3' read A
AI130003.1 Clone IMAGE:1713039 uterus 3' read P
CB066778.1 Clone IMAGE: pancreas 3' read PA
AI086133.1 Clone IMAGE:1677771 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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