Fumarylacetoacetate hydrolase (fumarylacetoacetase) (FAH)

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Finding cDNAs

UGID:139604 UniGene Hs.73875 Homo sapiens (human) FAH

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Fumarylacetoacetate hydrolase (fumarylacetoacetase) (FAH)

Human protein-coding gene FAH. Represented by 312 ESTs from 154 cDNA libraries. Corresponds to reference sequence NM_000137.2. [UniGene 139604 - Hs.73875]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_000128.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	FAH gene product	H. sapiens	100.0	418
XP_001155533.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarylacetoacetase isoform 3	P. troglodytes	99.8	420
NP_034306.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Fah gene product	M. musculus	91.9	418
NP_955895.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fah gene product	D. rerio	80.1	346
NP_001080458.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarylacetoacetase	X. laevis	79.2	419
NP_509083.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein FAH-1	C. elegans	69.3	414
NP_524830.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarylacetoacetase	D. melanogaster	68.5	412
NP_172669.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarylacetoacetase	A. thaliana	63.4	418
XP_001701519.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	predicted protein	C. reinhardtii	57.6	425
XP_960499.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarylacetoacetase	N. crassa	56.4	427
Other hits (2 of 50) [Show all]		Species	Id(%)	Len(aa)
XP_001109382.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarylacetoacetase isoform 1	M. mulatta	97.6	418
XP_003901338.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarylacetoacetase	P. anubis	97.6	418

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	pancreas; lymph; pharynx; mouth; salivary gland; thyroid; connective tissue; blood; eye; lung; testis; ovary; kidney; uncharacterized tissue; brain; skin; cervix; liver; mixed; placenta; esophagus; spleen; mammary gland; prostate; heart; adipose tissue; uterus; intestine; muscle; embryonic tissue; lymph node; stomach; ganglia; bone; pituitary gland; adrenal gland

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	15
Map position:	15q25.1
UniSTS entry:		RH13
UniSTS entry:		GDB:369113
UniSTS entry:	Chr 15	RH136637

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

BT007160.1	Homo sapiens fumarylacetoacetate hydrolase (fumarylacetoacetase) mRNA, complete cds	P
NM_000137.2	Homo sapiens fumarylacetoacetate hydrolase (fumarylacetoacetase) (FAH), mRNA	PA
M55150.1	Human fumarylacetoacetate hydrolase mRNA, complete cds	P
BC002527.1	Homo sapiens fumarylacetoacetate hydrolase (fumarylacetoacetase), mRNA (cDNA clone MGC:1557 IMAGE:3139988), complete cds	PA
AK313951.1	Homo sapiens cDNA, FLJ94596, Homo sapiens fumarylacetoacetate hydrolase (fumarylacetoacetase)(FAH), mRNA	P
X51728.1	Human mRNA for fumarylacetoacetase (EC 3.7.1.2)	P
S63549.1	fumaryl acetoacetate hydrolase {alternatively spliced S product} [human, mRNA Partial Mutant, 117 nt]
S63548.1	fumaryl acetoacetate hydrolase {alternatively spliced L product} [human, mRNA Partial Mutant, 324 nt]

EST sequences (10 of 312) [Show all sequences]

AA969802.1	Clone IMAGE:1572718	kidney	3' read	PA
AA946814.1	Clone IMAGE:1589100	kidney	3' read	PA
BX113482.1	Clone IMAGp998A11264_;_IMAGE:162706	mammary gland		P
BX117399.1	Clone IMAGp998B165997	brain	5' read	A
AI207324.1	Clone IMAGE:1762157	kidney	3' read	PA
CB164152.1	Clone L17N670205n1-36-E09	liver	5' read	P
CB123338.1	Clone L13SNU387-3-B07	liver	5' read	P
CB149777.1	Clone L15CKK1-47-B06	liver	5' read	P
AI197878.1	Clone IMAGE:1860157	brain	3' read
AI273103.1	Clone IMAGE:1986297	uterus	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria