Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B)

Restricted Expression:

embryoid body [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

uterus; amniotic fluid; mouth; testis; bladder; brain; lung; skin; uncharacterized tissue; embryonic tissue; pancreas; stomach; intestine; prostate; mixed; liver; connective tissue; mammary gland; kidney; spleen; muscle; esophagus; cervix; pharynx

NCBI

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Finding cDNAs

UGID:139517 UniGene Hs.72901 Homo sapiens (human) CDKN2B

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Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B)

SELECTED PROTEIN SIMILARITIES

Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.

Reference Protein		Species	Id(%)	Len(aa)
NP_004927.2	cyclin-dependent kinase inhibitor 2B isoform 1	H. sapiens	100.0	137
XP_001478592.1	PREDICTED: similar to Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)	M. musculus	91.4	127
NP_001090330.1	hypothetical protein LOC779240	X. laevis	57.7	104

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	9
Map position:	9p21
UniSTS entry:	Chr 9	STS-N34320
UniSTS entry:	Chr 9	PMC108944P1
UniSTS entry:	Chr 9	GDB:626109
UniSTS entry:	Chr 9	D9S1752
UniSTS entry:	Chr 9	D9S1605
UniSTS entry:	Chr 9	D9S958
UniSTS entry:	Chr 9	GDB:679533
UniSTS entry:	Chr 8	RH48146

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AF488731.1	Homo sapiens CDKN2B-related p15INK4B mRNA, 3'UTR	A
AF488411.1	Homo sapiens clone 7-2 translocation breakpoint region
AF488410.1	Homo sapiens cyclin-dependent kinase inhibitor mRNA, partial cds	A
AF488409.1	Homo sapiens cyclin-dependent kinase inhibitor (CDK4I) mRNA, partial sequence, alternatively spliced	P
L36844.1	Homo sapiens (clone p15INK4B/HA5) CDK inhibitory protein mRNA, complete cds	P
CR536529.1	Homo sapiens full open reading frame cDNA clone RZPDo834H0422D for gene CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); complete cds, incl. stopcodon	P
NM_004936.3	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA	PA
U17075.1	Human p14-CDK inhibitor mRNA, complete cds	P
BC014469.1	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), mRNA (cDNA clone MGC:23110 IMAGE:4871014), complete cds	PA
BC018984.2	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), mRNA (cDNA clone IMAGE:4328695), partial cds	A
NM_078487.2	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA	PA
AF004819.1	Homo sapiens alternative spliced form of p15 CDK inhibitor mRNA, complete cds	P

EST sequences (10 of 148) [Show all sequences]

AA975511.1	Clone IMAGE:1558204	lung	3' read	A
CB046586.1	Clone IMAGE:3252936	kidney	5' read
CB046585.1	Clone IMAGE:3252936	kidney	3' read	A
AI160044.1	Clone IMAGE:1721575	uterus	3' read
BX100722.1	Clone IMAGp998C21612_;_IMAGE:277196	brain		A
AI204636.1	Clone IMAGE:1734951	testis	3' read	A
AI445908.1	Clone IMAGE:2140775	stomach	3' read	A
AU279609.1	Clone CHONS2000652	connective tissue	5' read	P
AI832338.1	Clone IMAGE:2375299	intestine	3' read	A
AI868405.1	Clone IMAGE:2146717	mixed	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria