> Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B)
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UGID:139517     UniGene Hs.72901     Homo sapiens (human)   CDKN2B Order cDNA clone, Links
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B)

Human protein-coding gene CDKN2B. Represented by 146 ESTs from 72 cDNA libraries. EST representation biased toward embryoid body. Corresponds to 2 reference sequences (different isoforms). [UniGene 139517 - Hs.72901]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004927.2 CDKN2B gene product H. sapiens 100.0 137
NP_031696.1 Cdkn2b gene product M. musculus 91.4 127
Other hits (2 of 12) [Show all]SpeciesId(%)Len(aa)
XP_001107263.1 PREDICTED: cyclin-dependent kinase 4 inhibitor B isoform 2 M. mulatta 99.3 137
XP_003312069.1 PREDICTED: cyclin-dependent kinase 4 inhibitor B isoform 1 P. troglodytes 97.1 137

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: embryoid body [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: amniotic fluid; liver; mouth; testis; stomach; skin; brain; lung; bladder; embryonic tissue; prostate; uterus; pancreas; intestine; uncharacterized tissue; mammary gland; mixed; connective tissue; kidney; spleen; muscle; esophagus; cervix; pharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 9
Map position: 9p21
UniSTS entry: Chr 9 STS-N34320
UniSTS entry: Chr 9 PMC108944P1
UniSTS entry: Chr 9 GDB:626109
UniSTS entry: Chr 9 D9S1752
UniSTS entry: Chr 9 D9S1605
UniSTS entry: Chr 9 D9S958
UniSTS entry: Chr 9 GDB:679533
UniSTS entry: Chr 8 RH48146
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AF488731.1 Homo sapiens CDKN2B-related p15INK4B mRNA, 3'UTR A
AF488411.1 Homo sapiens clone 7-2 translocation breakpoint region
AF488410.1 Homo sapiens cyclin-dependent kinase inhibitor mRNA, partial cds A
AF488409.1 Homo sapiens cyclin-dependent kinase inhibitor (CDK4I) mRNA, partial sequence, alternatively spliced P
L36844.1 Homo sapiens (clone p15INK4B/HA5) CDK inhibitory protein mRNA, complete cds P
CR536529.1 Homo sapiens full open reading frame cDNA clone RZPDo834H0422D for gene CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); complete cds, incl. stopcodon P
NM_004936.3 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA PA
U17075.1 Human p14-CDK inhibitor mRNA, complete cds P
BC014469.1 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), mRNA (cDNA clone MGC:23110 IMAGE:4871014), complete cds PA
BC018984.2 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), mRNA (cDNA clone IMAGE:4328695), partial cds A
NM_078487.2 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA PA
AF004819.1 Homo sapiens alternative spliced form of p15 CDK inhibitor mRNA, complete cds P

EST sequences (10 of 146) [Show all sequences]

AA975511.1 Clone IMAGE:1558204 lung 3' read A
CB046586.1 Clone IMAGE:3252936 kidney 5' read
CB046585.1 Clone IMAGE:3252936 kidney 3' read A
AI160044.1 Clone IMAGE:1721575 uterus 3' read
BX100722.1 Clone IMAGp998C21612_;_IMAGE:277196 brain A
AI204636.1 Clone IMAGE:1734951 testis 3' read A
AI445908.1 Clone IMAGE:2140775 stomach 3' read A
AU279609.1 Clone CHONS2000652 connective tissue 5' read
AI832338.1 Clone IMAGE:2375299 intestine 3' read A
AI868405.1 Clone IMAGE:2146717 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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