> Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
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UGID:4540352     UniGene Hs.728751     Homo sapiens (human)   CYP3A4 Order cDNA clone, Links
Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)

Human protein-coding gene CYP3A4. Represented by 361 ESTs from 40 cDNA libraries. EST representation biased toward adult. Corresponds to 2 reference sequences (different isoforms). [UniGene 4540352 - Hs.728751]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_059488.2 CYP3A4 gene product H. sapiens 100.0 502
NP_031845.1 Cyp3a13 gene product M. musculus 79.4 501
NP_001083508.1 uncharacterized protein LOC398964 X. laevis 65.9 499
NP_001032515.1 cyp3a65 gene product D. rerio 62.9 501
NP_996200.1 Cyp9f2, isoform B D. melanogaster 45.8 179
Other hits (2 of 37) [Show all]SpeciesId(%)Len(aa)
NP_001116247.1 CYP3A4 gene product P. troglodytes 98.8 502
XP_003895805.1 PREDICTED: cytochrome P450 3A8-like P. anubis 96.4 502

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; connective tissue; mammary gland; intestine; mouth; kidney; adrenal gland; uncharacterized tissue; mixed; stomach; brain; muscle
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 7
Map position: 7q21.1
UniSTS entry: Chr 7 RH68186
UniSTS entry: Chr 7 D7S2832 [Map Viewer]
UniSTS entry: Chr 7 CYP3A7_3262
UniSTS entry: Chr 7 SHGC-35234 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

AJ563377.1 Homo sapiens mRNA for cytochrome P450 (CYP3A43/CYP3A4 gene) P
AJ563376.1 Homo sapiens partial mRNA for cytochrome P450 (CYP3A43 and CYP3A4 genes) P
AJ563375.1 Homo sapiens mRNA for cytochrome P450 (CYP3A43/CYP3A4 gene) P
BC069418.1 Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4, mRNA (cDNA clone MGC:97095 IMAGE:7262313), complete cds P
BC069352.1 Homo sapiens cDNA clone IMAGE:7262301, containing frame-shift errors P
AY606313.2 Homo sapiens cytochrome P450-3A4-like (CYP3A4) mRNA, complete sequence P
AF182273.1 Homo sapiens cytochrome P450-3A4 (CYP3A4) mRNA, complete cds P
BC101631.1 Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4, mRNA (cDNA clone MGC:126680 IMAGE:8069137), complete cds P
NM_017460.5 Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), transcript variant 1, mRNA P
DQ924960.1 Homo sapiens cytochrome P450 family 3 subfamily A polypeptide 4 (CYP3A4) mRNA, complete cds P
AK312967.1 Homo sapiens cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA P
X12387.1 Human mRNA for cytochrome P-450 (cyp3 locus) PA
NM_001202855.2 Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), transcript variant 2, mRNA P
M14096.1 Human cytochrome P-450 nifedipine oxidase mRNA, complet cds P
M18907.1 Human P450 mRNA encoding nifedipine oxidase, complete cds P

EST sequences (10 of 361) [Show all sequences]

CB154142.1 Clone L17N670205-4-A03 liver 5' read P
CB157599.1 Clone L17N670205n1-11-G12 liver 5' read P
CB157627.1 Clone L17N670205n1-12-B08 liver 5' read P
CB156859.1 Clone L17N670205n1-5-A05 liver 5' read P
CB157183.1 Clone L17N670205n1-7-D01 liver 5' read P
CB157672.1 Clone L17N670205n1-12-G10 liver 5' read P
CB161712.1 Clone L17N670205n1-51-A08 liver 5' read P
CB161761.1 Clone L17N670205n1-51-F08 liver 5' read P
CB164067.1 Clone L17N670205n1-37-D08 liver 5' read P
CB164407.1 Clone L17N670205n1-47-D12 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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