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UGID:4410388     UniGene Hs.727986     Homo sapiens (human)   SMAD3
SMAD family member 3 (SMAD3)

Human protein-coding gene SMAD3. Represented by 376 ESTs from 195 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 4410388 - Hs.727986]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_058049.3 Smad3 gene product M. musculus 100.0 424
NP_037227.1 mothers against decapentaplegic homolog 3 R. norvegicus 100.0 424
XP_001111262.1 PREDICTED: mothers against decapentaplegic homolog 3 isoform 6 M. mulatta 100.0 424
XP_003901143.1 PREDICTED: mothers against decapentaplegic homolog 3 P. anubis 100.0 424
XP_001159972.2 PREDICTED: mothers against decapentaplegic homolog 3 isoform 1 P. troglodytes 100.0 424
NP_005893.1 SMAD3 gene product H. sapiens 100.0 424
NP_001164300.1 SMAD3 gene product C. lupus familiaris 100.0 424
NP_999302.1 SMAD3 gene product S. scrofa 100.0 424
NP_001192734.1 mothers against decapentaplegic homolog 3 B. taurus 100.0 424
NP_989806.1 SMAD3 gene product G. gallus 99.5 425
NP_571646.1 smad3a gene product D. rerio 98.6 423
NP_001079320.1 SMAD family member 3 X. laevis 97.7 424
NP_511079.1 smad on X D. melanogaster 76.5 485
NP_498931.2 Protein SMA-2 C. elegans 56.5 404
Other hits (2 of 31) [Show all]SpeciesId(%)Len(aa)
XP_003209624.1 PREDICTED: mothers against decapentaplegic homolog 3-like, partial M. gallopavo 98.5 401
XP_001367375.2 PREDICTED: mothers against decapentaplegic homolog 3 isoform 1 M. domestica 98.2 507

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; pancreas; mammary gland; embryonic tissue; liver; intestine; cervix; mouth; vascular; connective tissue; lymph node; lung; mixed; kidney; amniotic fluid; muscle; heart; esophagus; blood; skin; eye; adipose tissue; thymus; placenta; testis; ovary; prostate; trachea; bone marrow; bladder; adrenal gland; uterus; stomach; spleen; salivary gland; bone; thyroid; pharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 15
Map position: 15q22.33
UniSTS entry: Chr 15 G20255
UniSTS entry: Chr 15 A005A06 [Map Viewer]
UniSTS entry: Chr 15 RH44526 [Map Viewer]
UniSTS entry: Chr 15 STS-U68019
UniSTS entry: Chr 15 RH47017 [Map Viewer]
UniSTS entry: Chr 15 STS-AA026105
UniSTS entry: Madh3
UniSTS entry: Chr 15 Madh3
UniSTS entry: Madh3
UniSTS entry: Chr 15 MADH3_2337
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (22)

BC050743.1 Homo sapiens SMAD family member 3, mRNA (cDNA clone MGC:60396 IMAGE:6094328), complete cds PA
AL110265.1 Homo sapiens mRNA; cDNA DKFZp586N0721 (from clone DKFZp586N0721) A
NM_005902.3 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1, mRNA PA
CR749287.1 Homo sapiens mRNA; cDNA DKFZp686J10186 (from clone DKFZp686J10186) A
AB209616.1 Homo sapiens mRNA for MAD, mothers against decapentaplegic homolog 3 variant protein P
AK026690.1 Homo sapiens cDNA: FLJ23037 fis, clone LNG02036, highly similar to HSU68019 Homo sapiens mad protein homolog (hMAD-3) mRNA PA
BC000414.1 Homo sapiens SMAD family member 3, mRNA (cDNA clone IMAGE:2961412) A
BC007496.1 Homo sapiens SMAD family member 3, mRNA (cDNA clone IMAGE:2961412) A
AK290881.1 Homo sapiens cDNA FLJ76792 complete cds, highly similar to Homo sapiens SMAD, mothers against DPP homolog 3 (Drosophila) (SMAD3), mRNA P
EU016554.1 Homo sapiens mutant mothers against decapentaplegic 3 (SMAD3) mRNA, partial sequence; alternatively spliced
EU016553.1 Homo sapiens mutant mothers against decapentaplegic 3 (SMAD3) mRNA, partial sequence; alternatively spliced
EU016552.1 Homo sapiens mutant mothers against decapentaplegic 3 (SMAD3) mRNA, partial sequence; alternatively spliced
AK313812.1 Homo sapiens cDNA, FLJ94430
U68019.1 Homo sapiens mad protein homolog (hMAD-3) mRNA, complete cds PA
AF151027.1 Homo sapiens HSPC193 mRNA, complete cds A
AK316017.1 Homo sapiens cDNA, FLJ78916 complete cds, highly similar to Mothers against decapentaplegic homolog 3 (SMAD3) P
AK300614.1 Homo sapiens cDNA FLJ59989 complete cds, highly similar to Mothers against decapentaplegic homolog 3 (SMAD3) P
AK298139.1 Homo sapiens cDNA FLJ54532 complete cds, highly similar to Mothers against decapentaplegic homolog 3 (SMAD3) P
NM_001145104.1 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 4, mRNA P
NM_001145103.1 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 3, mRNA P
NM_001145102.1 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 2, mRNA P
U76622.1 Human mad homolog JV15-2 mRNA, complete cds P

EST sequences (10 of 376) [Show all sequences]

AI167699.1 Clone IMAGE:1682525 skin 3' read A
BX096540.1 Clone IMAGp998I13742_;_IMAGE:327252 heart
BX105189.1 Clone IMAGp998C24791_;_IMAGE:345935 heart
AI190962.1 Clone IMAGE:1732565 heart 3' read A
CB164289.1 Clone L17N670205n1-29-H09 liver 5' read
CB163271.1 Clone L17N670205n1-22-G04 liver 5' read A
CB157974.1 Clone L18POOL1n1-6-E01 liver 5' read A
CB160752.1 Clone L18POOL1n1-23-D09 liver 5' read
CB125732.1 Clone L5HLK1s1-29-F07 liver 5' read A
CB116059.1 Clone L8SCK0-12-H08 liver 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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