> Thyroid hormone receptor, alpha (THRA)
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UGID:130815     UniGene Hs.724     Homo sapiens (human)   THRA Order cDNA clone, Links
Thyroid hormone receptor, alpha (THRA)

Human protein-coding gene THRA. Represented by 388 ESTs from 174 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 130815 - Hs.724]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_003241.2 THRA gene product H. sapiens 100.0 489
XP_863301.2 PREDICTED: thyroid hormone receptor alpha isoform 5 C. lupus familiaris 100.0 409
NP_999355.1 THRA gene product S. scrofa 100.0 409
XP_002719397.1 PREDICTED: thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) isoform 2 O. cuniculus 99.8 490
NP_835161.1 Thra gene product M. musculus 99.8 409
NP_001094389.1 THRA gene product O. aries 99.8 409
NP_112396.2 Thra gene product R. norvegicus 99.6 491
NP_001081595.1 thyroid hormone receptor alpha-A X. laevis 92.3 417
XP_001921013.3 PREDICTED: thyroid hormone receptor alpha D. rerio 90.7 409
Other hits (2 of 21) [Show all]SpeciesId(%)Len(aa)
XP_001500679.1 PREDICTED: thyroid hormone receptor alpha-like isoform 1 E. caballus 99.2 519
NP_001039794.1 THRA gene product B. taurus 99.0 508

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; intestine; lung; muscle; eye; uncharacterized tissue; testis; uterus; prostate; mammary gland; kidney; placenta; salivary gland; mixed; spinal cord; pancreas; ovary; cervix; ear; thyroid; embryonic tissue; connective tissue; adrenal gland; spleen; pituitary gland; stomach; skin; heart; ascites; blood; nerve; ganglia; bone; liver; parathyroid; bladder
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q11.2
UniSTS entry: Chr 17 RH110 [Map Viewer]
UniSTS entry: Chr 17 D10S2160
UniSTS entry: Chr 17 MARC_26124-26125:1030369359:1
UniSTS entry: Chr 17 THRA
UniSTS entry: Chr 17 PMC87157P2
UniSTS entry: Chr 17 THRA_2263
UniSTS entry: Chr 17 GDB:180966
UniSTS entry: Chr 17 GDB:196130
UniSTS entry: Chr 17 PMC64989P2
UniSTS entry: Chr 17 D17S1979 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (21)

NM_003250.5 Homo sapiens thyroid hormone receptor, alpha (THRA), transcript variant 2, mRNA PA
BC062421.1 Homo sapiens cDNA clone IMAGE:6500508, partial cds A
NM_199334.3 Homo sapiens thyroid hormone receptor, alpha (THRA), transcript variant 1, mRNA PA
CR541915.1 Homo sapiens full open reading frame cDNA clone RZPDo834E0733D for gene THRA, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); complete cds, without stopcodon P
AB209346.1 Homo sapiens mRNA for thyroid hormone receptor, alpha isoform 1 variant protein P
M24900.1 Human triiodothyronine recptor (THRA1, ear1), and ear2 genes, last 2 exons each P
BC002728.2 Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), mRNA (cDNA clone MGC:3645 IMAGE:3628335), complete cds PA
BC000261.1 Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), mRNA (cDNA clone MGC:2353 IMAGE:3501886), complete cds PA
J03239.1 Human c-erbA-alpha-2 gene encoding thyroid hormone receptor type alpha-2 mRNA, complete cds, clone hTR-alpha-2 P
AK290071.1 Homo sapiens cDNA FLJ75155 complete cds, highly similar to Homo sapiens thyroid hormone receptor, alpha (erythroblasticleukemia viral (v-erb-a) oncogene homolog, avian) (THRA),transcript variant 1, mRNA P
AK290530.1 Homo sapiens cDNA FLJ75491 complete cds, highly similar to Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) (THRA), transcript variant 2, mRNA P
AK311344.1 Homo sapiens cDNA, FLJ18386 P
X55005.1 Homo sapiens mRNA for thyroid hormone receptor alpha 1 THRA1, (c-erbA-1 gene) PA
Y00479.1 H.sapiens mRNA for thyroid hormone receptor P
AF522368.1 Homo sapiens thyroid hormone receptor alpha3 mRNA, partial cds P
AB307686.1 Homo sapiens NR1A1 mRNA for thyroid hormone receptor alpha, complete cds P
BC035137.1 Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), mRNA (cDNA clone MGC:43240 IMAGE:5264048), complete cds PA
NM_001190919.1 Homo sapiens thyroid hormone receptor, alpha (THRA), transcript variant 4, mRNA P
NM_001190918.1 Homo sapiens thyroid hormone receptor, alpha (THRA), transcript variant 3, mRNA P
HQ692859.1 Homo sapiens thyroid normone nuclear receptor alpha variant 1 (NR1A1) mRNA, complete cds P
M24899.1 Human triiodothyronine (ear7) mRNA, complete cds P

EST sequences (10 of 388) [Show all sequences]

AI003984.1 Clone IMAGE:1625169 embryonic tissue 3' read
AI144477.1 Clone IMAGE:1705756 heart 3' read A
CB050953.1 Clone IMAGE:3289338 prostate 3' read A
CB054874.1 Clone IMAGE:3291789 brain 5' read
CB054873.1 Clone IMAGE:3291789 brain 3' read A
AI160845.1 Clone IMAGE:1704990 heart 3' read
AI276376.1 Clone IMAGE:1990579 uterus 3' read A
AI084142.1 Clone IMAGE:1750898 brain 3' read
AI364089.1 Clone IMAGE:2016713 brain 3' read P
AI391498.1 Clone IMAGE:2107682 uncharacterized tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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