Dual oxidase 2 (DUOX2)

Restricted Expression:

adult [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

skin; muscle; intestine; prostate; trachea; thyroid; lung; brain; pharynx; uncharacterized tissue; pancreas; eye; mouth; uterus; cervix; mixed; liver

NCBI

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UGID:139396 UniGene Hs.71377 Homo sapiens (human) DUOX2

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Dual oxidase 2 (DUOX2)

Human protein-coding gene DUOX2. Represented by 182 ESTs from 39 cDNA libraries. EST representation biased toward adult. Corresponds to reference sequence NM_014080.4. [UniGene 139396 - Hs.71377]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_054799.4 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	DUOX2 gene product	H. sapiens	100.0	1547
NP_808278.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	dual oxidase 2 precursor	M. musculus	86.7	1516
XP_001919394.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: dual oxidase 1, partial	D. rerio	58.9	1419
NP_608715.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	dual oxidase, isoform B	D. melanogaster	51.6	370
NP_490686.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein BLI-3	C. elegans	47.1	169
Other hits (2 of 35) [Show all]		Species	Id(%)	Len(aa)
XP_510367.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: dual oxidase 2 isoform 2	P. troglodytes	99.4	1547
XP_003900932.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: LOW QUALITY PROTEIN: dual oxidase 2	P. anubis	96.5	1512

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	15
Map position:	15q15.3
UniSTS entry:	Chr 15	SHGC-57395
UniSTS entry:	Chr 1	D11S3114

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (5)

NM_014080.4	Homo sapiens dual oxidase 2 (DUOX2), mRNA	PA
AF181972.1	Homo sapiens NADH/NADPH thyroid oxidase p138-tox mRNA, complete cds	PA
AF267981.1	Homo sapiens putative NADPH oxidase/peroxidase DUOX2 mRNA, complete cds	PA
AF230496.1	Homo sapiens NADPH thyroid oxidase 2 (THOX2) mRNA, complete cds	PA
AB209010.1	Homo sapiens mRNA for dual oxidase 2 precursor variant protein	P

EST sequences (10 of 182) [Show all sequences]

T10426.1	Clone hbc151	pancreas	5' read
BX282381.1	Clone IMAGp998B246739_;_IMAGE:2698295	cervix		P
AW170493.1	Clone IMAGE:2698295	cervix	3' read	A
AW204802.1	Clone IMAGE:2719536	mixed	3' read	A
CD625160.1		uncharacterized tissue		P
CD625161.1		uncharacterized tissue		P
CD625162.1		uncharacterized tissue
CD625163.1		uncharacterized tissue
AW752673.1		intestine		P
AW800095.1		uterus

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria