> ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (ARFGEF1)
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UGID:2726220     UniGene Hs.656902     Homo sapiens (human)   ARFGEF1 Links
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (ARFGEF1)

Human protein-coding gene ARFGEF1. Represented by 344 ESTs from 183 cDNA libraries. Corresponds to reference sequence NM_006421.4. [UniGene 2726220 - Hs.656902]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001162263.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 4 P. troglodytes 100.0 1848
NP_006412.2 ARFGEF1 gene product H. sapiens 100.0 1848
XP_001096475.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1-like M. mulatta 99.9 1848
XP_003902882.1 PREDICTED: LOW QUALITY PROTEIN: brefeldin A-inhibited guanine nucleotide-exchange protein 1 P. anubis 99.8 1840
XP_859322.2 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 4 C. lupus familiaris 99.7 1848
XP_004011771.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 O. aries 99.7 1848
XP_001494609.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 E. caballus 99.7 1807
XP_001928045.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 S. scrofa 99.5 1848
NP_776422.1 ARFGEF1 gene product B. taurus 99.5 1848
NP_001095900.1 brefeldin A-inhibited guanine nucleotide-exchange protein 1 M. musculus 99.2 1845
XP_003201354.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 D. rerio 94.9 1840
NP_609675.2 sec71, isoform A D. melanogaster 74.8 1643
NP_001021798.2 Protein AGEF-1, isoform a C. elegans 57.3 1521
XP_962785.2 hypothetical protein NCU07658 N. crassa 55.0 687
XP_001694943.1 SEC7/BIG-like ARF-guanine nucleotide exchange factor C. reinhardtii 54.1 778
NP_191645.1 SEC7-like guanine nucleotide exchange family protein A. thaliana 52.6 953
NP_001090523.1 cytohesin 2 X. laevis 52.0 171
NP_010454.3 Sec7p S. cerevisiae 50.6 637
Other hits (2 of 51) [Show all]SpeciesId(%)Len(aa)
XP_001066125.2 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 R. norvegicus 99.1 1845
XP_001368081.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 M. domestica 99.0 1848

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; brain; liver; eye; adrenal gland; uncharacterized tissue; mammary gland; embryonic tissue; kidney; thymus; uterus; mixed; thyroid; placenta; connective tissue; intestine; lung; mouth; pancreas; prostate; skin; bone; blood; ovary; adipose tissue; larynx; spleen; trachea; lymph node; muscle; stomach; vascular; bone marrow; bladder; salivary gland; ear; parathyroid; ascites; nerve; pharynx; ganglia; esophagus
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8q13
UniSTS entry: Chr 8 RH91158
UniSTS entry: Chr 8 G06218
UniSTS entry: Chr 8 RH93991
UniSTS entry: BIG1
UniSTS entry: Chr 8 D8S1378E
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AL117446.1 Homo sapiens mRNA; cDNA DKFZp434L057 (from clone DKFZp434L057); partial cds PA
AK127799.1 Homo sapiens cDNA FLJ45900 fis, clone OCBBF3025630, highly similar to Brefeldin A-inhibited guanine nucleotide-exchange protein 1 P
AK123660.1 Homo sapiens cDNA FLJ41666 fis, clone FEBRA2028158, highly similar to Homo sapiens guanine nucleotide exchange factor mRNA PA
NM_006421.4 Homo sapiens ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (ARFGEF1), mRNA PA
AK001788.1 Homo sapiens cDNA FLJ10926 fis, clone OVARC1000465, weakly similar to PROTEIN TRANSPORT PROTEIN SEC7 P
AF084520.1 Homo sapiens brefeldin A-inhibited guanine nucleotide-exchange protein 1 mRNA, complete cds P
AF111162.1 Homo sapiens guanine nucleotide exchange factor mRNA, complete cds P
AB209324.1 Homo sapiens mRNA for brefeldin A-inhibited guanine nucleotide-exchange protein 1 variant protein P
AK022557.1 Homo sapiens cDNA FLJ12495 fis, clone NT2RM2001652, highly similar to Brefeldin A-inhibited guanine nucleotide-exchange protein 1 P
AK025637.1 Homo sapiens cDNA: FLJ21984 fis, clone HEP06222, highly similar to AF111162 Homo sapiens guanine nucleotide exchange factor mRNA PA

EST sequences (10 of 344) [Show all sequences]

AI015733.1 Clone IMAGE:1622207 embryonic tissue 3' read A
AI024526.1 Clone IMAGE:1639608 testis 3' read
AI125675.1 Clone IMAGE:1736794 testis 3' read
CB049750.1 Clone IMAGE:3271549 prostate 3' read A
CB049751.1 Clone IMAGE:3271549 prostate 5' read A
AI220317.1 Clone IMAGE:1841953 mixed 3' read A
AI198668.1 Clone IMAGE:1753559 testis 3' read A
CB155893.1 Clone B2N807043-12-G09 brain 5' read
AI288129.1 Clone IMAGE:1988635 uterus 3' read A
R36291.1 Clone IMAGE:38262 brain 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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