> Major histocompatibility complex, class I, E (HLA-E)
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UGID:2480798     UniGene Hs.650174     Homo sapiens (human)   HLA-E Order cDNA clone, Links
Major histocompatibility complex, class I, E (HLA-E)

Human protein-coding gene HLA-E. Represented by 1911 ESTs from 482 cDNA libraries. Corresponds to reference sequence NM_005516.5. [UniGene 2480798 - Hs.650174]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005507.3 HLA-E gene product H. sapiens 100.0 357
NP_034521.1 H2-Q10 gene product M. musculus 76.6 324
Other hits (2 of 14) [Show all]SpeciesId(%)Len(aa)
NP_001038963.1 PATR-E gene product P. troglodytes 99.1 349
NP_001108438.1 MAMU-E gene product M. mulatta 91.9 358

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; brain; uncharacterized tissue; intestine; pancreas; blood; spleen; placenta; uterus; mammary gland; kidney; skin; stomach; mixed; connective tissue; heart; testis; tonsil; muscle; bone marrow; amniotic fluid; bone; eye; adipose tissue; ovary; thymus; lymph; liver; lymph node; prostate; parathyroid; esophagus; ganglia; nerve; adrenal gland; vascular; thyroid; mouth; cervix; embryonic tissue; pharynx; bladder; trachea; ascites; pituitary gland; larynx; salivary gland; umbilical cord; epididymis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.3
UniSTS entry: Chr 6 PMC151808P1
UniSTS entry: Chr 6 SHGC-31506 [Map Viewer]
UniSTS entry: Chr 6 RH45169 [Map Viewer]
UniSTS entry: Chr 6 RH36163 [Map Viewer]
UniSTS entry: Chr 6 D1S1925E
UniSTS entry: Chr 1 D11S2921
UniSTS entry: Chr 1 sY3084
UniSTS entry: Chr 6 A008W41
UniSTS entry: Chr 1 D10S275
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (23)

AY216681.1 Homo sapiens nonclassical MHC class I antigen (HLA-E) mRNA, HLA-E*010301 allele, complete cds P
AY221103.1 Homo sapiens MHC class I antigen (HLA-E) mRNA, HLA-E*010303 variant allele, complete cds P
BX538084.1 Homo sapiens mRNA; cDNA DKFZp686P19218 (from clone DKFZp686P19218) PA
NM_005516.5 Homo sapiens major histocompatibility complex, class I, E (HLA-E), mRNA PA
M20022.1 Human HLA-E class I mRNA P
AB209870.1 Homo sapiens mRNA for HLA class I histocompatibility antigen, E alpha chain precursor variant protein P
M31183.1 Homo sapiens (cosmid clone cd3.3) MHC class I HLA-B51 mRNA, 3' end of cds P
AJ293263.1 Homo sapiens mRNA for MHC class I antigen, HLA-E*01033 allele (HLA-E gene) P
AJ293264.1 Homo sapiens mRNA for MHC class I antigen, HLA-E*0101 allele (HLA-E gene) P
X56841.1 H.sapiens HLA-E gene PA
BC002578.2 Homo sapiens major histocompatibility complex, class I, E, mRNA (cDNA clone MGC:1408 IMAGE:3140835), complete cds PA
AK225048.1 Homo sapiens mRNA for HLA class I histocompatibility antigen, alpha chain E precursor variant, clone: adKA03449 PA
BC004297.1 Homo sapiens, clone IMAGE:3622619, mRNA, partial cds PA
X64879.1 H.sapiens mRNA for HLA-E heavy chain (exons 4 - 7) P
AK292391.1 Homo sapiens cDNA FLJ78238 complete cds, highly similar to Homo sapiens major histocompatibility complex, class I, E, mRNA P
AK314411.1 Homo sapiens cDNA, FLJ95191 P
AK098434.1 Homo sapiens cDNA FLJ25568 fis, clone JTH03907, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E E*0101/E*0102 PRECURSOR P
AK301125.1 Homo sapiens cDNA FLJ53747 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain E precursor P
AK298695.1 Homo sapiens cDNA FLJ55134 complete cds, moderately similar to HLA class I histocompatibility antigen, alpha chain E precursor P
AK296822.1 Homo sapiens cDNA FLJ52681 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain E precursor P
L78934.1 Homo sapiens isolate SPAARN 70 HLA-E gene exons 2 and 3 P
L78455.1 Homo sapiens isolate SPA 70 HLA-E gene exons 2 and 3 P
BC040479.1 Homo sapiens major histocompatibility complex, class I, E, mRNA (cDNA clone MGC:32811 IMAGE:4696327), complete cds PA

EST sequences (10 of 1911) [Show all sequences]

AA866087.1 Clone IMAGE:1459552 kidney 3' read P
AA978115.1 Clone IMAGE:1578550 mixed 3' read A
AA987672.1 Clone IMAGE:1604361 lung 3' read A
AA993999.1 Clone IMAGE:1628913 mixed 3' read A
AI025411.1 Clone IMAGE:1647327 parathyroid 3' read A
AI028525.1 Clone IMAGE:1649674 parathyroid 3' read PA
AI031981.1 Clone IMAGE:1650800 parathyroid 3' read A
AI034018.1 Clone IMAGE:1646705 parathyroid 3' read A
AI041413.1 Clone IMAGE:1648819 parathyroid 3' read A
AI041978.1 Clone IMAGE:1667740 parathyroid 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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