Cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6)

Restricted Expression:

liver [show more like this]

liver tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

liver; mixed; mammary gland; testis; uncharacterized tissue; brain; intestine; prostate; uterus; mouth; spleen; blood

NCBI

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Finding cDNAs

UGID:2478880 UniGene Hs.648256 Homo sapiens (human) CYP2D6

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Cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6)

Human protein-coding gene CYP2D6. Represented by 125 ESTs from 32 cDNA libraries. EST representation biased toward liver; liver tumor. Corresponds to 2 reference sequences (different isoforms). [UniGene 2478880 - Hs.648256]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_000097.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	CYP2D6 gene product	H. sapiens	100.0	496
NP_062797.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cytochrome P450, family 2, subfamily d, polypeptide 22	M. musculus	81.0	498
NP_001087043.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cytochrome P450, family 2, subfamily D, polypeptide 6	X. laevis	63.0	486
NP_956914.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cyp2p9 gene product	D. rerio	53.3	481
NP_728191.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cytochrome P450-18a1, isoform A	D. melanogaster	45.3	192
Other hits (2 of 32) [Show all]		Species	Id(%)	Len(aa)
NP_001035712.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cytochrome P450 2D6	P. troglodytes	99.2	496
XP_003905682.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: cytochrome P450 2D17-like isoform 1	P. anubis	96.4	496

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	22
Map position:	22q13.1
UniSTS entry:	Chr 22	GDB:187817
UniSTS entry:	Chr 22	GDB:632773
UniSTS entry:	Chr 22	GDB:222783

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

M24499.1	Human cytochrome P450db1 mRNA, 3' end, clone HLD8.2	P
NM_000106.5	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1, mRNA	PA
BC066877.1	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone IMAGE:7002156), partial cds	P
BC067432.1	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:79259 IMAGE:7002157), complete cds	P
CR456430.1	Homo sapiens CYP2D6 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.CYP2D6.V2)	P
M20403.1	Human cytochrome P450 db1 mRNA, complete cds	P
BC075024.2	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:104161 IMAGE:30915622), complete cds	P
BC075023.2	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:104003 IMAGE:30915411), complete cds	P
AY663390.1	Homo sapiens CYP2D variant mRNA, partial cds, alternatively spliced	PA
AB209492.1	Homo sapiens premature mRNA for debrisoquine 4-hydroxylase mutant allele variant	P
NM_001025161.2	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 2, mRNA	PA
BC106758.1	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:120390 IMAGE:40024717), complete cds	P
BC106757.1	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:120389 IMAGE:40024713), complete cds	P
BC126858.1	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6, mRNA (cDNA clone MGC:120392 IMAGE:40024719), complete cds	P
BC126857.1	Homo sapiens cDNA clone IMAGE:40024718	P
AK308211.1	Homo sapiens cDNA, FLJ98159	P
AK309600.1	Homo sapiens cDNA, FLJ99641	P
X08006.1	Homo sapiens mRNA for cytochrome P450 db1	P
X16865.1	Human mRNA for cytochrome P-450IID (clone pMP32)	PA

EST sequences (10 of 125) [Show all sequences]

BX096000.1	Clone IMAGp998F01383	mixed	5' read	P
CB162434.1	Clone L17N670205n1-14-G04	liver	5' read	P
CB116939.1	Clone L7N800102-4-B04	liver	5' read	P
CB122244.1	Clone L7N800102-9-A10	liver	5' read	P
CB120362.1	Clone L7N800102-8-E04	liver	5' read	P
CB124853.1	Clone L7N800102-6-E03	liver	5' read	P
CB142772.1	Clone L7N800102-13-H08	liver	5' read	P
CB144729.1	Clone L7N800102-16-C10	liver	5' read	P
CB121435.1	Clone L7N800102s1-1-D07	liver	5' read	P
CB137789.1	Clone L7N800102s1-7-G11	liver	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria