> TIMP metallopeptidase inhibitor 3 (TIMP3)
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UGID:2360416     UniGene Hs.644633     Homo sapiens (human)   TIMP3 Order cDNA clone, Links
TIMP metallopeptidase inhibitor 3 (TIMP3)

Human protein-coding gene TIMP3. Represented by 1496 ESTs from 371 cDNA libraries. Corresponds to reference sequence NM_000362.4. [UniGene 2360416 - Hs.644633]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001028128.1 TIMP3 gene product M. mulatta 100.0 210
NP_001162201.1 metalloproteinase inhibitor 3 precursor P. anubis 100.0 210
XP_515097.2 PREDICTED: metalloproteinase inhibitor 3 P. troglodytes 100.0 210
NP_000353.1 TIMP3 gene product H. sapiens 100.0 210
XP_538410.2 PREDICTED: metalloproteinase inhibitor 3 isoform 1 C. lupus familiaris 100.0 210
XP_003126121.3 PREDICTED: metalloproteinase inhibitor 3 S. scrofa 100.0 210
NP_001159659.1 TIMP3 gene product O. aries 100.0 210
NP_001075339.1 TIMP3 gene product E. caballus 99.5 210
NP_035725.1 Timp3 gene product M. musculus 98.1 210
NP_001079064.1 metalloproteinase inhibitor 3 precursor X. laevis 85.0 212
NP_997939.1 fgb gene product D. rerio 50.0 142
Other hits (2 of 15) [Show all]SpeciesId(%)Len(aa)
NP_776898.2 TIMP3 gene product B. taurus 99.0 210
NP_037018.2 Timp3 gene product R. norvegicus 98.1 210

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: placenta; brain; mixed; eye; lung; connective tissue; skin; testis; uterus; pancreas; bone; uncharacterized tissue; embryonic tissue; kidney; intestine; thyroid; esophagus; muscle; vascular; adrenal gland; mammary gland; spleen; stomach; ear; heart; nerve; bone marrow; liver; prostate; pituitary gland; trachea; ganglia; cervix; parathyroid; ovary; mouth; spinal cord; salivary gland; adipose tissue; umbilical cord; thymus; pharynx; larynx; blood
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 22
Map position: 22q12.3
UniSTS entry: Chr 22 REN79710
UniSTS entry: Chr 22 D22S1555 [Map Viewer]
UniSTS entry: Chr 22 D22S979E
UniSTS entry: Chr 22 REN79697
UniSTS entry: Chr 22 REN79443
UniSTS entry: Chr 22 RH27838
UniSTS entry: Chr 22 RH10
UniSTS entry: Chr 22 REN79699
UniSTS entry: Chr 22 REN79698
UniSTS entry: Chr 22 REN79695
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (18)

BT006848.1 Homo sapiens tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) mRNA, complete cds P
NM_000362.4 Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA PA
CR456593.1 Homo sapiens TIMP3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.TIMP3.V2) P
U14394.1 Human tissue inhibitor of metalloproteinases-3 mRNA, complete cds P
D45917.1 Homo sapiens mRNA for TIMP-3, partial cds (C-terminus region)
BC014277.2 Homo sapiens TIMP metallopeptidase inhibitor 3, mRNA (cDNA clone MGC:11079 IMAGE:3689386), complete cds PA
U02571.1 Human tissue inhibitor of metalloproteinase-3 precursor (TIMP-3) mRNA, complete cds P
AK311702.1 Homo sapiens cDNA, FLJ18744
AK314871.1 Homo sapiens cDNA, FLJ95772, Homo sapiens tissue inhibitor of metalloproteinase 3 (Sorsby fundusdystrophy, pseudoinflammatory) (TIMP3), mRNA P
AK098517.1 Homo sapiens cDNA FLJ25651 fis, clone SYN01176
AK298126.1 Homo sapiens cDNA FLJ51917 complete cds, highly similar to Metalloproteinase inhibitor 3 precursor P
U67195.1 Human tissue inhibitor of metalloproteinase-3 mRNA, complete cds PA
X77690.1 H.sapiens mRNA for K222 expressed in degenerative retinas
X80791.1 H.sapiens K222TA2 mRNA
X76227.1 H.sapiens TIMP3 mRNA for tissue inhibitor of metalloproteinases-3 P
S78453.1 TIMP-3=tissue inhibitor of metalloproteinases-3 [human, THP-1 cells, mRNA, 1284 nt] PA
L15078.1 Homo sapiens metalloproteinase-3 tissue inhibitor (TIMP3) mRNA, 3' end P
AF035289.1 Homo sapiens clone 23969 mRNA sequence A

EST sequences (10 of 1496) [Show all sequences]

AA970310.1 Clone IMAGE:1573014 kidney 3' read
AA974177.1 Clone IMAGE:1586260 uncharacterized tissue 3' read
AA975669.1 Clone IMAGE:1588970 kidney 3' read
AA976365.1 Clone IMAGE:1591486 kidney 3' read
AA991667.1 Clone IMAGE:1622000 embryonic tissue 3' read
AA994118.1 Clone IMAGE:1630795 mammary gland 3' read
AA995488.1 Clone IMAGE:1610444 uncharacterized tissue 3' read
AA999708.1 Clone IMAGE:1636297 kidney 3' read A
AI000778.1 Clone IMAGE:1613811 uncharacterized tissue 3' read
AA902265.1 Clone IMAGE:1522817 lung 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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