> Vinculin (VCL)
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UGID:2225067     UniGene Hs.643896     Homo sapiens (human)   VCL Order cDNA clone, Links
Vinculin (VCL)

Human protein-coding gene VCL. Represented by 1092 ESTs from 356 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 2225067 - Hs.643896]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003903793.1 PREDICTED: vinculin isoform 2 P. anubis 100.0 1133
XP_507854.2 PREDICTED: vinculin isoform 3 P. troglodytes 100.0 1133
NP_054706.1 VCL gene product H. sapiens 100.0 1133
XP_001918197.1 PREDICTED: vinculin isoform 2 E. caballus 100.0 1133
NP_999099.1 VCL gene product S. scrofa 100.0 1066
XP_001118118.1 PREDICTED: vinculin, partial M. mulatta 100.0 545
XP_002718451.1 PREDICTED: vinculin isoform 1 O. cuniculus 99.9 1133
NP_001178299.1 vinculin B. taurus 99.8 1133
NP_033528.3 Vcl gene product M. musculus 99.8 1065
XP_004021530.1 PREDICTED: vinculin isoform 2 O. aries 99.7 1133
NP_001100718.1 vinculin R. norvegicus 99.6 1065
NP_001122153.1 vcl gene product D. rerio 90.9 1130
NP_476820.1 vinculin D. melanogaster 63.6 960
NP_501105.2 Protein DEB-1, isoform b C. elegans 58.6 321
Other hits (2 of 28) [Show all]SpeciesId(%)Len(aa)
XP_001364414.1 PREDICTED: vinculin isoform 1 M. domestica 99.1 1132
XP_536395.3 PREDICTED: vinculin C. lupus familiaris 98.5 1167

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; brain; uterus; embryonic tissue; placenta; lung; intestine; mixed; trachea; spleen; blood; uncharacterized tissue; ascites; connective tissue; mouth; kidney; prostate; eye; larynx; mammary gland; ganglia; liver; pancreas; adipose tissue; skin; ovary; bone; ear; amniotic fluid; lymph node; bone marrow; muscle; stomach; vascular; esophagus; salivary gland; thyroid; heart; bladder; pharynx; cervix; parathyroid; adrenal gland; pineal gland; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q22.2
UniSTS entry: Chr 10 D10S2342
UniSTS entry: Chr 10 STS-M33308
UniSTS entry: Chr 10 GDB:193875
UniSTS entry: Vcl
UniSTS entry: Chr 10 D10S2142 [Map Viewer]
UniSTS entry: Chr 10 VCL
UniSTS entry: BARC0060
UniSTS entry: Chr 1 D15S1477
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AK126978.1 Homo sapiens cDNA FLJ45031 fis, clone BRAWH3018548, highly similar to Vinculin P
NM_003373.3 Homo sapiens vinculin (VCL), transcript variant 2, mRNA PA
NM_014000.2 Homo sapiens vinculin (VCL), transcript variant 1, mRNA PA
M33308.1 Human vinculin mRNA, complete cds P
AK055524.1 Homo sapiens cDNA FLJ30962 fis, clone HCASM2000560
AL832130.1 Homo sapiens mRNA; cDNA DKFZp686H1210 (from clone DKFZp686H1210) PA
AK300280.1 Homo sapiens cDNA FLJ53006 complete cds, highly similar to Vinculin P
AK304823.1 Homo sapiens cDNA FLJ59659 complete cds, highly similar to Vinculin P
AK296509.1 Homo sapiens cDNA FLJ55698 complete cds, highly similar to Vinculin P
BC013847.1 Homo sapiens vinculin, mRNA (cDNA clone IMAGE:4387297) PA
BC039174.1 Homo sapiens vinculin, mRNA (cDNA clone MGC:21734 IMAGE:4520338), complete cds PA

EST sequences (10 of 1092) [Show all sequences]

AA975607.1 Clone IMAGE:1588923 kidney 3' read
AA975610.1 Clone IMAGE:1588931 kidney 3' read
R15352.1 Clone IMAGE:29683 brain 5' read
AA904909.1 Clone IMAGE:1504504 mixed 3' read
AI003089.1 Clone IMAGE:1699868 kidney 3' read
AA909152.1 Clone IMAGE:1540905 mixed 3' read
AI041158.1 Clone IMAGE:1642614 testis 3' read A
AI041865.1 Clone IMAGE:1660445 mixed 3' read
AI049601.1 Clone IMAGE:1700922 kidney 3' read P
AI049603.1 Clone IMAGE:1700926 kidney 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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