> Cathepsin K (CTSK)
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UGID:2139360     UniGene Hs.632466     Homo sapiens (human)   CTSK Order cDNA clone, Links
Cathepsin K (CTSK)

Human protein-coding gene CTSK. Represented by 810 ESTs from 219 cDNA libraries. Corresponds to reference sequence NM_000396.3. [UniGene 2139360 - Hs.632466]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000387.1 CTSK gene product H. sapiens 100.0 328
NP_031828.2 Ctsk gene product M. musculus 89.4 328
NP_001106314.1 cathepsin K precursor X. laevis 75.2 325
NP_001017778.1 ctsk gene product D. rerio 70.2 328
NP_725347.1 cysteine proteinase-1, isoform A D. melanogaster 54.6 333
NP_507199.1 CathePsin L family member (cpl-1) C. elegans 52.3 304
NP_564321.2 cysteine proteinase-like protein A. thaliana 50.4 284
XP_001697622.1 cysteine endopeptidase C. reinhardtii 46.9 196
Other hits (2 of 59) [Show all]SpeciesId(%)Len(aa)
NP_001027984.1 CTSK gene product M. mulatta 99.4 328
XP_001171151.1 PREDICTED: cathepsin K isoform 4 P. troglodytes 99.4 328

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; uterus; skin; pancreas; kidney; connective tissue; brain; mixed; lung; eye; placenta; stomach; heart; intestine; testis; bone; mammary gland; pharynx; embryonic tissue; liver; thymus; thyroid; blood; cervix; ovary; esophagus; ear; adrenal gland; vascular; muscle; nerve; mouth; ganglia; tonsil; adipose tissue; lymph node; prostate; umbilical cord; epididymis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1q21
UniSTS entry: Chr 1 RH18001 [Map Viewer]
UniSTS entry: Chr 1 CTSK
UniSTS entry: Chr 1 WI-12245 [Map Viewer]
UniSTS entry: WI-9390
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AK130134.1 Homo sapiens cDNA FLJ26624 fis, clone MPC03724, highly similar to Cathepsin K precursor (EC 3.4.22.38) P
NM_000396.3 Homo sapiens cathepsin K (CTSK), mRNA PA
AY429530.1 Homo sapiens CTSKv_1 mRNA sequence; alternatively spliced P
CR541719.1 Homo sapiens full open reading frame cDNA clone RZPDo834E1237D for gene CTSK, cathepsin K (pycnodysostosis); complete cds, without stopcodon P
CR541675.1 Homo sapiens full open reading frame cDNA clone RZPDo834C0328D for gene CTSK, cathepsin K (pycnodysostosis); complete cds, incl. stopcodon P
BC016058.1 Homo sapiens cathepsin K, mRNA (cDNA clone MGC:23107 IMAGE:4860926), complete cds PA
U13665.1 Human cathepsin O (CTSO) mRNA, complete cds P
AK312880.1 Homo sapiens cDNA, FLJ93324 P
S79895.1 OC2=cathepsin O2 [human, spleen, mRNA, 1482 nt] P
U20280.1 Human cathepsin X mRNA, complete cds P

EST sequences (10 of 810) [Show all sequences]

AA971882.1 Clone IMAGE:1584795 lung 3' read A
AA976577.1 Clone IMAGE:1558671 lung 3' read
AA977001.1 Clone IMAGE:1558695 lung 3' read A
AA983654.1 Clone IMAGE:1559545 intestine 3' read A
AA991374.1 Clone IMAGE:1608915 mammary gland 3' read A
AA994341.1 Clone IMAGE:1628218 mixed 3' read A
AA903392.1 Clone IMAGE:1518515 uncharacterized tissue 3' read A
AA926902.1 Clone IMAGE:1542095 mixed 3' read
AI032965.1 Clone IMAGE:1655665 mixed 3' read A
AI040269.1 Clone IMAGE:1663787 skin 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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