> Farnesyl-diphosphate farnesyltransferase 1 (FDFT1)
NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs
UGID:2062939     UniGene Hs.593928     Homo sapiens (human)   FDFT1 Order cDNA clone, Links
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1)

Human protein-coding gene FDFT1. Represented by 1599 ESTs from 460 cDNA libraries. Corresponds to reference sequence NM_004462.3. [UniGene 2062939 - Hs.593928]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001086419.1 PREDICTED: squalene synthase isoform 8 M. mulatta 100.0 416
XP_003902455.1 PREDICTED: squalene synthase isoform 1 P. anubis 100.0 416
XP_001141492.1 PREDICTED: squalene synthase isoform 13 P. troglodytes 100.0 416
NP_004453.3 FDFT1 gene product H. sapiens 100.0 416
NP_034321.2 Fdft1 gene product M. musculus 91.8 415
NP_001189454.1 squalene synthase D. rerio 77.3 405
NP_012060.1 bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase S. cerevisiae 56.3 364
XP_001703447.1 farnesyl-diphosphate farnesyltransferase C. reinhardtii 54.8 372
NP_195191.2 squalene synthase 2 A. thaliana 52.9 374
XP_959817.1 squalene synthetase N. crassa 50.5 337
Other hits (2 of 42) [Show all]SpeciesId(%)Len(aa)
XP_002709483.1 PREDICTED: squalene synthase O. cuniculus 97.6 416
XP_001915483.1 PREDICTED: squalene synthase-like E. caballus 96.3 402

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; skin; placenta; blood; intestine; embryonic tissue; mixed; lung; uncharacterized tissue; eye; uterus; prostate; liver; pancreas; ovary; muscle; bladder; lymph; kidney; stomach; mammary gland; salivary gland; connective tissue; adrenal gland; heart; spleen; bone marrow; thymus; lymph node; bone; adipose tissue; thyroid; ear; epididymis; tonsil; larynx; ascites; pharynx; mouth; vascular; trachea; cervix; umbilical cord; amniotic fluid; ganglia; pineal gland; esophagus; parathyroid; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p23.1-p22
UniSTS entry: Chr 8 WI-18910 [Map Viewer]
UniSTS entry: Chr 8 SHGC-11994 [Map Viewer]
UniSTS entry: Chr 8 G60297
UniSTS entry: Chr 8 RH79108 [Map Viewer]
UniSTS entry: Chr 8 SHGC-30677 [Map Viewer]
UniSTS entry: Chr 8 STS-X69141
UniSTS entry: Chr 1 RH80031
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (29)

BT006704.1 Homo sapiens farnesyl-diphosphate farnesyltransferase 1 mRNA, complete cds P
L06105.1 Human hepatic squalene synthetase mRNA, complete cds P
NM_004462.3 Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA PA
CR457033.1 Homo sapiens full open reading frame cDNA clone RZPDo834B0218D for gene FDFT1, farnesyl-diphosphate farnesyltransferase 1; complete cds, incl. stopcodon P
AY007159.1 Homo sapiens clone CDABP0116 mRNA sequence P
L06070.1 Human squalene synthetase (ERG9) mRNA, complete cds P
BC003573.1 Homo sapiens farnesyl-diphosphate farnesyltransferase 1, mRNA (cDNA clone MGC:2200 IMAGE:3538137), complete cds PA
BC009251.2 Homo sapiens farnesyl-diphosphate farnesyltransferase 1, mRNA (cDNA clone MGC:4480 IMAGE:2961623), complete cds PA
AK057726.1 Homo sapiens cDNA FLJ33164 fis, clone UTERU2000542, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK311362.1 Homo sapiens cDNA, FLJ18404 P
AK311246.1 Homo sapiens cDNA, FLJ18288 P
BC029641.1 Homo sapiens farnesyl-diphosphate farnesyltransferase 1, mRNA (cDNA clone MGC:25135 IMAGE:4514761), complete cds PA
AK098682.1 Homo sapiens cDNA FLJ25816 fis, clone TST07502, highly similar to FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) P
AK098208.1 Homo sapiens cDNA FLJ40889 fis, clone UTERU2000925 P
AK301617.1 Homo sapiens cDNA FLJ53107 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK300245.1 Homo sapiens cDNA FLJ50669 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK300059.1 Homo sapiens cDNA FLJ50660 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK297868.1 Homo sapiens cDNA FLJ55760 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK296043.1 Homo sapiens cDNA FLJ50548 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
BC034440.1 Homo sapiens farnesyl-diphosphate farnesyltransferase 1, mRNA (cDNA clone IMAGE:4510069) PA
AK316351.1 Homo sapiens cDNA, FLJ79250 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK316182.1 Homo sapiens cDNA, FLJ79081 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) PA
AK316033.1 Homo sapiens cDNA, FLJ78932 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) PA
AK315993.1 Homo sapiens cDNA, FLJ78892 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK316534.1 Homo sapiens cDNA, FLJ79433 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK316531.1 Homo sapiens cDNA, FLJ79430 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
AK293545.1 Homo sapiens cDNA FLJ50447 complete cds, highly similar to Squalene synthetase (EC 2.5.1.21) P
X69141.1 H.sapiens mRNA for squalene synthase PA
S76822.1 squalene synthase=farnesyl diphosphate:farnesyl diphosphate farnesyltransferase [human, liver, mRNA, 1673 nt] PA

EST sequences (10 of 1599) [Show all sequences]

AA864810.1 Clone IMAGE:1456679 kidney 3' read A
AA970146.1 Clone IMAGE:1581823 mixed 3' read P
AA985342.1 Clone IMAGE:1629371 brain 3' read P
AA985358.1 Clone IMAGE:1629463 brain 3' read P
AI004081.1 Clone IMAGE:1619933 testis 3' read P
AA927356.1 Clone IMAGE:1552470 uncharacterized tissue 3' read A
AA928418.1 Clone IMAGE:1560070 intestine 3' read PA
AI032815.1 Clone IMAGE:1656616 mixed 3' read P
AI033785.1 Clone IMAGE:1656854 mixed 3' read A
T26604.1 Clone LLAB334B12 brain 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help