> Topoisomerase (DNA) II binding protein 1 (TOPBP1)
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UGID:2062390     UniGene Hs.593379     Homo sapiens (human)   TOPBP1 Order cDNA clone, Links
Topoisomerase (DNA) II binding protein 1 (TOPBP1)

Human protein-coding gene TOPBP1. Represented by 315 ESTs from 161 cDNA libraries. Corresponds to reference sequence NM_007027.3. [UniGene 2062390 - Hs.593379]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_008958.2 TOPBP1 gene product H. sapiens 100.0 1521
XP_516761.3 PREDICTED: DNA topoisomerase 2-binding protein 1 P. troglodytes 99.9 1521
NP_795953.2 Topbp1 gene product M. musculus 82.7 1514
NP_001082568.1 topoisomerase (DNA) II binding protein 1 X. laevis 72.2 1511
NP_001186667.1 topoisomerase (DNA) II binding protein 1 D. rerio 61.2 1525
Other hits (2 of 22) [Show all]SpeciesId(%)Len(aa)
XP_003895149.1 PREDICTED: DNA topoisomerase 2-binding protein 1 P. anubis 98.8 1526
XP_001112636.2 PREDICTED: DNA topoisomerase 2-binding protein 1 M. mulatta 98.7 1526

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; uncharacterized tissue; embryonic tissue; mixed; bone marrow; cervix; thyroid; eye; lymph node; uterus; intestine; blood; liver; mammary gland; kidney; skin; placenta; thymus; prostate; connective tissue; lung; ovary; pancreas; bladder; adrenal gland; spleen; mouth; tonsil; stomach; muscle; ascites; heart; lymph; nerve; bone; vascular
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 3
Map position: 3q22.1
UniSTS entry: Chr 3 SHGC-31992 [Map Viewer]
UniSTS entry: Chr 3 G20668
UniSTS entry: Chr 3 A006B05
UniSTS entry: SHGC-57698
UniSTS entry: Chr 1 D17S610
UniSTS entry: Chr 1 D11S2612
UniSTS entry: Chr 1 RH80030
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AB019397.1 Homo sapiens mRNA for DNA topoisomerase II binding protein, complete cds P
NM_007027.3 Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), mRNA PA
AK026229.1 Homo sapiens cDNA: FLJ22576 fis, clone HSI02511 PA
BC126209.1 Homo sapiens topoisomerase (DNA) II binding protein 1, mRNA (cDNA clone MGC:161487 IMAGE:8991925), complete cds P
BC151237.1 Homo sapiens topoisomerase (DNA) II binding protein 1, mRNA (cDNA clone MGC:167825 IMAGE:8860504), complete cds PA
BC032633.1 Homo sapiens topoisomerase (DNA) II binding protein 1, mRNA (cDNA clone IMAGE:5395690), partial cds PA
BC017552.1 Homo sapiens topoisomerase (DNA) II binding protein 1, mRNA (cDNA clone IMAGE:3911342), with apparent retained intron A
Y18557.1 Homo sapiens mRNA for KIAA0259 protein, partial, 3' UTR PA
AK302584.1 Homo sapiens cDNA FLJ61726 complete cds, highly similar to DNA topoisomerase 2-binding protein 1 P
D87448.1 Homo sapiens mRNA for KIAA0259 gene, partial cds P

EST sequences (10 of 315) [Show all sequences]

AA970099.1 Clone IMAGE:1581727 mixed 3' read A
AI004886.1 Clone IMAGE:1621057 testis 3' read P
AI028590.1 Clone IMAGE:1644075 testis 3' read A
AI032829.1 Clone IMAGE:1656623 mixed 3' read P
BX092549.1 Clone IMAGp998I01384_;_IMAGE:200136 mixed P
AI186277.1 Clone IMAGE:1724258 placenta 3' read A
AI219075.1 Clone IMAGE:1759722 placenta 3' read A
AI221574.1 Clone IMAGE:1759628 placenta 3' read A
AI241853.1 Clone IMAGE:1977307 brain 3' read A
AI241899.1 Clone IMAGE:1977558 brain 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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