Fumarate hydratase (FH)

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UGID:2061501 UniGene Hs.592490 Homo sapiens (human) FH

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Fumarate hydratase (FH)

Human protein-coding gene FH. Represented by 584 ESTs from 233 cDNA libraries. Corresponds to reference sequence NM_000143.3. [UniGene 2061501 - Hs.592490]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_001160068.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarate hydratase, mitochondrial isoform 3	P. troglodytes	100.0	509
NP_000134.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	FH gene product	H. sapiens	100.0	509
XP_001094968.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarate hydratase, mitochondrial isoform 2	M. mulatta	99.8	509
XP_003893750.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: fumarate hydratase, mitochondrial	P. anubis	99.8	509
NP_034339.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Fh1 gene product	M. musculus	97.8	506
NP_957257.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fh gene product	D. rerio	92.1	508
NP_498642.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein FUM-1, isoform a	C. elegans	81.8	493
NP_727108.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lethal (1) G0255, isoform B	D. melanogaster	80.9	466
NP_001078075.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarate hydratase, class II	A. thaliana	78.9	487
XP_959454.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarate hydratase, mitochondrial precursor	N. crassa	75.8	529
NP_015061.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarase FUM1	S. cerevisiae	72.7	475
XP_001689951.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	fumarate hydratase	C. reinhardtii	71.6	497
Other hits (2 of 56) [Show all]		Species	Id(%)	Len(aa)
NP_001069271.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	FH gene product	B. taurus	98.8	509
NP_001155363.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	FH gene product	O. aries	98.8	509

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	skin; brain; intestine; eye; lung; placenta; kidney; uncharacterized tissue; liver; uterus; embryonic tissue; muscle; testis; mixed; bone marrow; adipose tissue; ovary; cervix; mammary gland; pancreas; heart; blood; vascular; pituitary gland; larynx; tonsil; lymph; adrenal gland; stomach; bone; lymph node; mouth; esophagus; ascites; prostate; parathyroid; connective tissue; spinal cord; pharynx; spleen; thymus; amniotic fluid; thyroid; nerve; umbilical cord; pineal gland

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	1
Map position:	1q42.1
UniSTS entry:	Chr 13	RH39631
UniSTS entry:	Chr 1	D1S258E	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

BT009839.1	Homo sapiens fumarate hydratase mRNA, complete cds	P
NM_000143.3	Homo sapiens fumarate hydratase (FH), nuclear gene encoding mitochondrial protein, mRNA	P
M15502.1	Human mitochondrial fumarase mRNA, complete cds	P
U48857.1	Human fumarase mRNA, nuclear gene encoding mitochondrial protein, complete cds	P
BC003108.1	Homo sapiens fumarate hydratase, mRNA (cDNA clone MGC:2061 IMAGE:3502012), complete cds	PA
BC017444.1	Homo sapiens fumarate hydratase, mRNA (cDNA clone MGC:15363 IMAGE:3606118), complete cds	PA
AK312415.1	Homo sapiens cDNA, FLJ92753, Homo sapiens fumarate hydratase (FH), nuclear gene encodingmitochondrial protein, mRNA	P
U59309.1	Human fumarase precursor (FH) mRNA, nuclear gene encoding mitochondrial protein, complete cds	P

EST sequences (10 of 584) [Show all sequences]

AA974123.1	Clone IMAGE:1585604	lung	3' read
AA995089.1	Clone IMAGE:1635009	kidney	3' read	A
AI028549.1	Clone IMAGE:1645578	testis	3' read	A
AI026813.1	Clone IMAGE:1645666	testis	3' read	A
AI040350.1	Clone IMAGE:1667631	parathyroid	3' read	P
AI041675.1	Clone IMAGE:1667656	parathyroid	3' read	PA
AA928619.1	Clone IMAGE:1553002	uncharacterized tissue	3' read	A
AI091602.1	Clone IMAGE:1682973	parathyroid	3' read	PA
AI123936.1	Clone IMAGE:1688973	mixed	3' read	A
AI127003.1	Clone IMAGE:1707992	heart	3' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria