> Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE)
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UGID:131758     UniGene Hs.5920     Homo sapiens (human)   GNE Order cDNA clone, Links
Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE)

Human protein-coding gene GNE. Represented by 151 ESTs from 86 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 131758 - Hs.5920]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003312121.1 PREDICTED: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase P. troglodytes 100.0 752
NP_001121699.1 GNE gene product H. sapiens 100.0 752
XP_001082113.2 PREDICTED: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase M. mulatta 100.0 721
XP_003911552.1 PREDICTED: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1 P. anubis 100.0 721
XP_002707961.1 PREDICTED: UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase O. cuniculus 99.9 743
XP_001497363.2 PREDICTED: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1 E. caballus 99.7 752
NP_056643.3 Gne gene product M. musculus 99.1 752
NP_957177.1 gne gene product D. rerio 84.6 715
Other hits (2 of 18) [Show all]SpeciesId(%)Len(aa)
XP_003431623.1 PREDICTED: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1 C. lupus familiaris 99.3 751
NP_001161102.1 GNE gene product S. scrofa 99.3 551

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: pancreas; trachea; embryonic tissue; intestine; mixed; mammary gland; uterus; placenta; brain; eye; larynx; mouth; stomach; liver; skin; lung; bladder; prostate; muscle; cervix; uncharacterized tissue; thyroid; parathyroid; connective tissue; testis; kidney; spleen; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 9
Map position: 9p13.3
UniSTS entry: Chr 9 SHGC-36161 [Map Viewer]
UniSTS entry: Chr 9 RH66165
UniSTS entry: Chr 9 STS-D25668
UniSTS entry: Chr 9 SHGC-32868 [Map Viewer]
UniSTS entry: Gne
UniSTS entry: Chr 1 D17S1136
UniSTS entry: Chr 1 D10S16
UniSTS entry: Chr 1 D11S3114
UniSTS entry: Chr 12 D9S1794 [Map Viewer]
UniSTS entry: Chr 1 L17971
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

AJ238764.1 Homo sapiens mRNA for UDP-N-acetylglucosamine-2-epimerase / N-acetylmannosamine kinase PA
NM_005476.5 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 2, mRNA PA
AY531128.1 Homo sapiens isolate W7803-30 UDP-N-acetylglucosamine-2-epimerase / N-acetylmannosamine kinase (GNE) mRNA, complete cds PA
AY531127.1 Homo sapiens isolate Y9103-50 UDP-N-acetylglucosamine-2-epimerase / N-acetylmannosamine kinase (GNE) mRNA, complete cds PA
AY531126.1 Homo sapiens isolate Y7303-49 UDP-N-acetylglucosamine-2-epimerase / N-acetylmannosamine kinase (GNE) mRNA, complete cds PA
AF051852.1 Homo sapiens UDP-N-acetylglucosamine-2-epimerase mRNA, complete cds P
AF155663.1 Homo sapiens UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase mRNA, complete cds P
BC121179.2 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, mRNA (cDNA clone MGC:150583 IMAGE:40122902), complete cds P
AM697709.1 Homo sapiens mRNA for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE gene), GNE3 isoform P
AM697708.1 Homo sapiens mRNA for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE gene), putative GNE1 and GNE2 isoforms P
EU093084.1 Homo sapiens isolate GNE-1 mutant UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase mRNA, complete cds, alternatively spliced P
AK312539.1 Homo sapiens cDNA, FLJ92908, Homo sapiensUDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase(GNE), mRNA P
NM_001128227.2 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 1, mRNA PA
AK299488.1 Homo sapiens cDNA FLJ58375 complete cds, moderately similar to Bifunctional UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase P
AK296687.1 Homo sapiens cDNA FLJ52319 complete cds, highly similar to Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase P
AK295562.1 Homo sapiens cDNA FLJ51479 complete cds, highly similar to Bifunctional UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase P
NM_001190388.1 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 3, mRNA P
NM_001190384.1 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 5, mRNA P
NM_001190383.1 Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 4, mRNA P

EST sequences (10 of 151) [Show all sequences]

AA975828.1 Clone IMAGE:1558272 lung 3' read A
AA904919.1 Clone IMAGE:1504503 mixed 3' read A
AI079296.1 Clone IMAGE:1677440 mixed 3' read A
AI082844.1 Clone IMAGE:1662443 mixed 3' read A
AI091182.1 Clone IMAGE:1566543 mixed 3' read A
AA902332.1 Clone IMAGE:1521401 lung 3' read A
CB119558.1 Clone L8SCK0-27-E06 liver 5' read
CB119999.1 Clone L8SCK0-22-D12 liver 5' read A
R37907.1 Clone IMAGE:137696 placenta 5' read P
AI367161.1 Clone IMAGE:1935126 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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