Transcription factor 7 (T-cell specific, HMG-box) (TCF7)

Restricted Expression:

juvenile [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

thymus; uncharacterized tissue; intestine; adrenal gland; liver; lymph node; mammary gland; blood; uterus; connective tissue; brain; kidney; salivary gland; spleen; heart; mixed; vascular; pharynx; pancreas; placenta; skin; ascites; stomach; ganglia; testis; bone; epididymis; pineal gland; ovary; embryonic tissue; mouth; thyroid

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UGID:1846140 UniGene Hs.573153 Homo sapiens (human) TCF7

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Transcription factor 7 (T-cell specific, HMG-box) (TCF7)

Human protein-coding gene TCF7. Represented by 271 ESTs from 84 cDNA libraries. EST representation biased toward juvenile. Corresponds to 6 reference sequences (different isoforms). [UniGene 1846140 - Hs.573153]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_003193.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	TCF7 gene product	H. sapiens	100.0	383
XP_003310868.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: transcription factor 7 isoform 2	P. troglodytes	100.0	267
NP_033357.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Tcf7 gene product	M. musculus	98.0	302
NP_001012389.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	tcf7 gene product	D. rerio	74.1	354
NP_001082124.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lymphoid enhancer-binding factor 1	X. laevis	67.8	370
NP_001033798.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	pangolin, isoform I	D. melanogaster	63.3	270
Other hits (2 of 35) [Show all]		Species	Id(%)	Len(aa)
XP_001107710.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: transcription factor 7-like	M. mulatta	98.5	340
XP_001502876.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: transcription factor 7-like	E. caballus	98.0	251

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	5
Map position:	5q31.1
UniSTS entry:	Chr 5	PMC126018P1
UniSTS entry:	Chr 5	SGC35448	[Map Viewer]
UniSTS entry:	Chr 5	SGC35447	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

BC048769.1	Homo sapiens transcription factor 7 (T-cell specific, HMG-box), mRNA (cDNA clone MGC:47735 IMAGE:6063270), complete cds	PA
NM_003202.3	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 1, mRNA	P
NM_201632.3	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 2, mRNA	PA
NM_201634.3	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 4, mRNA	PA
NM_213648.3	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 5, mRNA	PA
BC072023.1	Homo sapiens transcription factor 7 (T-cell specific, HMG-box), mRNA (cDNA clone MGC:88737 IMAGE:6292932), complete cds	PA
Z47364.1	H.sapiens TCF-1 mRNA for T cell factor 1 splice form G
AK057580.1	Homo sapiens cDNA FLJ33018 fis, clone THYMU1000459, highly similar to Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 5, mRNA	P
AK310591.1	Homo sapiens cDNA, FLJ17633	P
AK093530.1	Homo sapiens cDNA FLJ36211 fis, clone THYMU2000300, highly similar to Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 5, mRNA	P
AL832816.1	Homo sapiens mRNA; cDNA DKFZp667B0424 (from clone DKFZp667B0424)	PA
NM_001134851.2	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 3, mRNA	PA
X59869.1	Human TCF-1 mRNA for T cell factor 1 (splice form A)	P
X59870.1	Human TCF-1 mRNA for T cell factor 1 (splice form B)	P
X59871.1	Human TCF-1 mRNA for T cell factor 1 (splice form C)	P
Z47361.1	H.sapiens TCF-1 mRNA for T cell factor 1 splice form D	P
Z47362.1	H.sapiens TCF-1 mRNA for T cell factor 1 splice form E	P
Z47363.1	H.sapiens TCF-1 mRNA for T cell factor 1 splice form F
NR_033449.1	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 6, non-coding RNA	PA

EST sequences (10 of 271) [Show all sequences]

T25455.1		thymus
AI246192.1	Clone IMAGE:1967071	lymph node	3' read
AI361855.1	Clone IMAGE:2027885	uncharacterized tissue	3' read
R48486.1	Clone IMAGE:153860	mammary gland	5' read
AI457956.1	Clone IMAGE:2145297	mixed	3' read
AI660365.1	Clone IMAGE:2345672	thymus	3' read
AI805261.1	Clone IMAGE:2073460	uncharacterized tissue	3' read
AI880889.1	Clone IMAGE:2355592	vascular	3' read
BX426109.2	Clone CS0DH004YI21	blood	3' read	P
BX426110.2	Clone CS0DH004YI21	blood	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria