X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4)

Restricted Expression:

infant [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

connective tissue; placenta; bone marrow; embryonic tissue; brain; prostate; blood; uncharacterized tissue; eye; testis; mixed; skin; mammary gland; uterus; pancreas; vascular; adrenal gland; liver; kidney; stomach; salivary gland; lymph node; pharynx; intestine

NCBI

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Finding cDNAs

UGID:1782848 UniGene Hs.567359 Homo sapiens (human) XRCC4

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X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4)

Human protein-coding gene XRCC4. Represented by 157 ESTs from 75 cDNA libraries. EST representation biased toward infant. Corresponds to 3 reference sequences (different isoforms). [UniGene 1782848 - Hs.567359]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_071801.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	XRCC4 gene product	H. sapiens	100.0	335
NP_082288.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Xrcc4 gene product	M. musculus	79.8	325
NP_001085360.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	X-ray repair complementing defective repair in Chinese hamster cells 4	X. laevis	53.4	311
NP_957080.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	xrcc4 gene product	D. rerio	45.4	196
Other hits (2 of 16) [Show all]		Species	Id(%)	Len(aa)
XP_001148110.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: DNA repair protein XRCC4 isoform 2	P. troglodytes	99.4	333
XP_003899945.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: DNA repair protein XRCC4 isoform 2	P. anubis	96.4	335

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	5
Map position:	5q14.2
UniSTS entry:	Chr 5	RH18150

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

BT007216.1	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 mRNA, complete cds	P
NM_003401.3	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 1, mRNA	PA
U40622.1	Human XRCC4 mRNA, complete cds	PA
NM_022406.2	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 2, mRNA	PA
NM_022550.2	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 3, mRNA	PA
AB017445.1	Homo sapiens XRCC4 mRNA, complete cds	P
BC005259.1	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4, mRNA (cDNA clone MGC:12297 IMAGE:3838919), complete cds	PA
BC016314.1	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4, mRNA (cDNA clone MGC:22739 IMAGE:4108822), complete cds	PA
AK290739.1	Homo sapiens cDNA FLJ75670 complete cds, highly similar to Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 2, mRNA	PA
BC010655.1	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4, mRNA (cDNA clone IMAGE:3873301), complete cds	PA

EST sequences (10 of 157) [Show all sequences]

AA909333.1	Clone IMAGE:1540574	mixed	3' read	A
R19860.1	Clone IMAGE:33864	brain	5' read	P
BX094180.1	Clone IMAGp998J23140_;_IMAGE:26811	brain		A
AI168769.1	Clone IMAGE:1661758	mixed	3' read	A
CB144620.1	Clone L16HLK3-22-E12	liver	5' read	P
AI270686.1	Clone IMAGE:1979374	stomach	3' read	A
CB146884.1	Clone L9SNU354-22-F10	liver	5' read	P
AI289105.1	Clone IMAGE:1991768	uterus	3' read	A
R39148.1	Clone IMAGE:26811	brain	3' read	A
AI795996.1	Clone IMAGE:2383277	kidney	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria