> F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7)
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UGID:1776824     UniGene Hs.561245     Homo sapiens (human)   FBXW7 Order cDNA clone, Links
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7)

Human protein-coding gene FBXW7. Represented by 307 ESTs from 123 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 1776824 - Hs.561245]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001084190.1 PREDICTED: f-box/WD repeat-containing protein 7 M. mulatta 100.0 706
XP_517482.2 PREDICTED: F-box/WD repeat-containing protein 7 isoform 2 P. troglodytes 100.0 706
NP_361014.1 FBXW7 gene product H. sapiens 100.0 706
XP_003899316.1 PREDICTED: F-box/WD repeat-containing protein 7 isoform 2 P. anubis 100.0 705
NP_001069717.1 FBXW7 gene product B. taurus 100.0 626
XP_003431296.1 PREDICTED: F-box/WD repeat-containing protein 7 O. anatinus 99.8 626
XP_001501354.1 PREDICTED: f-box/WD repeat-containing protein 7 isoform 1 E. caballus 99.7 710
XP_867701.2 PREDICTED: F-box/WD repeat-containing protein 7 isoform 3 C. lupus familiaris 99.6 711
NP_001171244.1 Fbxw7 gene product M. musculus 99.0 709
XP_693393.4 PREDICTED: f-box/WD repeat-containing protein 7 D. rerio 97.2 597
NP_001089186.1 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase X. laevis 96.6 705
NP_523922.1 archipelago, isoform C D. melanogaster 82.8 534
NP_001023975.1 Protein SEL-10, isoform b C. elegans 57.2 507
XP_957123.1 hypothetical protein NCU06483 N. crassa 49.0 196
Other hits (2 of 34) [Show all]SpeciesId(%)Len(aa)
XP_004017245.1 PREDICTED: F-box/WD repeat-containing protein 7 isoform 2 O. aries 99.4 704
XP_002716951.1 PREDICTED: F-box and WD repeat domain containing 7 O. cuniculus 99.3 738

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; mixed; liver; eye; muscle; skin; blood; mammary gland; pituitary gland; placenta; ear; kidney; embryonic tissue; lung; pancreas; lymph node; pharynx; thyroid; testis; uterus; heart; trachea; thymus; lymph; ascites; connective tissue; bone; ovary; intestine; prostate; vascular; salivary gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4q31.3
UniSTS entry: Chr 4 SHGC-67303 [Map Viewer]
UniSTS entry: Chr 4 Fbxw7
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (21)

BC059373.1 Homo sapiens cDNA clone IMAGE:5263248, containing frame-shift errors PA
AK001933.1 Homo sapiens cDNA FLJ11071 fis, clone PLACE1004937, moderately similar to SEL-10 PROTEIN P
CR749305.1 Homo sapiens mRNA; cDNA DKFZp686F23254 (from clone DKFZp686F23254) PA
NM_018315.4 Homo sapiens F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7), transcript variant 2, mRNA PA
NM_001013415.1 Homo sapiens F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7), transcript variant 3, mRNA P
AB209725.1 Homo sapiens mRNA for F-box protein FBW7 isoform 2 variant protein P
AK223449.1 Homo sapiens mRNA for F-box protein FBW7 isoform 2 variant, clone: FCC113E01 PA
BC117246.1 Homo sapiens F-box and WD repeat domain containing 7, mRNA (cDNA clone MGC:150855 IMAGE:40125797), complete cds P
BC117244.1 Homo sapiens F-box and WD repeat domain containing 7, mRNA (cDNA clone MGC:150853 IMAGE:40125795), complete cds P
AF383178.1 Homo sapiens F-box protein FBX30 mRNA, partial cds PA
AY033553.1 Homo sapiens F-box protein FBW7 mRNA, complete cds PA
AF411972.1 Homo sapiens archipelago beta form mRNA, complete cds PA
AF411971.1 Homo sapiens archipelago alpha form mRNA, complete cds P
NM_033632.3 Homo sapiens F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7), transcript variant 1, mRNA PA
AY008274.1 Homo sapiens F-box protein SEL10 (SEL10) mRNA, complete cds P
AY049984.1 Homo sapiens F-box protein CDC4 (CDC4) mRNA, complete cds P
AK315142.1 Homo sapiens cDNA, FLJ96109 P
BC143944.1 Homo sapiens F-box and WD repeat domain containing 7, mRNA (cDNA clone MGC:177479 IMAGE:9052462), complete cds P
AK299722.1 Homo sapiens cDNA FLJ59410 complete cds, highly similar to F-box/WD repeat protein 7 P
AK294568.1 Homo sapiens cDNA FLJ55681 complete cds, highly similar to F-box/WD repeat protein 7 P
BC037320.2 Homo sapiens F-box and WD repeat domain containing 7, mRNA (cDNA clone IMAGE:5260084), partial cds PA

EST sequences (10 of 307) [Show all sequences]

AI032986.1 Clone IMAGE:1657053 mixed 3' read
AI080718.1 Clone IMAGE:1678479 mixed 3' read P
AI090014.1 Clone IMAGE:1696197 uterus 3' read A
AI090532.1 Clone IMAGE:1691544 heart 3' read P
BX108047.1 Clone IMAGp998H085468_;_IMAGE:2211511 uterus PA
AI269047.1 Clone IMAGE:1857454 mixed 3' read P
CB108696.1 Clone L5HLK1-1-A12 liver 5' read
CB148182.1 Clone B1T694954-14-B05 brain 5' read
CB155216.1 Clone B2N807043-13-F08 brain 5' read P
CB115106.1 Clone L10ChoCK0-2-E07 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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