NK6 homeobox 1 (NKX6-1)

Restricted Expression:

germ cell tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

pancreas; ovary

NCBI

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UGID:1382584 UniGene Hs.546270 Homo sapiens (human) NKX6-1

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NK6 homeobox 1 (NKX6-1)

Human protein-coding gene NKX6-1. Represented by 10 ESTs from 3 cDNA libraries. EST representation biased toward germ cell tumor. Corresponds to reference sequence NM_006168.2. [UniGene 1382584 - Hs.546270]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_006159.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	NKX6-1 gene product	H. sapiens	100.0	366
XP_003310328.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: LOW QUALITY PROTEIN: homeobox protein Nkx-6.1	P. troglodytes	99.7	366
NP_659204.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Nkx6-1 gene product	M. musculus	96.7	364
NP_001093386.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	NK6 homeobox 1	X. laevis	84.0	350
NP_001002475.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	nkx6.1 gene product	D. rerio	79.8	311
NP_652614.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	HGTX	D. melanogaster	67.6	222
Other hits (2 of 27) [Show all]		Species	Id(%)	Len(aa)
XP_003898719.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein Nkx-6.1	P. anubis	99.5	365
XP_001104458.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein Nkx-6.1	M. mulatta	99.2	365

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

	Chromosome:	4
	Map position:	4q21.33

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (1)

NM_006168.2

Homo sapiens NK6 homeobox 1 (NKX6-1), mRNA

EST sequences (10)

CK820198.1	Clone IMAGE:5678331	pancreas	3' read	P
CK820199.1	Clone IMAGE:5678331	pancreas	5' read	P
BM142294.1	Clone IMAGE:5678331	pancreas	5' read	P
BM142348.1	Clone IMAGE:5678229	pancreas	5' read	P
BM142523.1	Clone IMAGE:5678229	pancreas	3' read	P
BU553046.1	Clone IMAGE:6577322	ovary	5' read	P
BU557077.1	Clone IMAGE:6584881	ovary	5' read	P
BU844509.1	Clone IMAGE:6577091	ovary	5' read	P
CA776168.1	Clone IMAGE:6134559	pancreas	5' read	P
CA941174.1	Clone IMAGE:6547538	pancreas	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria