> Pyruvate kinase, muscle (PKM)
NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs
UGID:1371084     UniGene Hs.534770     Homo sapiens (human)   PKM Order cDNA clone, Links
Pyruvate kinase, muscle (PKM)

Human protein-coding gene PKM. Represented by 9988 ESTs from 877 cDNA libraries. Corresponds to 7 reference sequences (different isoforms). [UniGene 1371084 - Hs.534770]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003314790.1 PREDICTED: pyruvate kinase isozymes M1/M2 P. troglodytes 100.0 604
NP_001193725.1 PKM gene product H. sapiens 100.0 604
XP_003901200.1 PREDICTED: pyruvate kinase isozymes M1/M2 isoform 2 P. anubis 100.0 530
XP_001091427.1 PREDICTED: pyruvate kinase isozymes M1/M2 isoform 9 M. mulatta 99.8 590
XP_535531.2 PREDICTED: pyruvate kinase isozymes M1/M2 isoform 1 C. lupus familiaris 99.6 530
NP_035229.2 Pkm gene product M. musculus 99.4 530
NP_001091236.1 uncharacterized protein LOC100037030 X. laevis 99.4 530
NP_955365.1 pkma gene product D. rerio 89.1 531
NP_732723.1 pyruvate kinase, isoform B D. melanogaster 76.8 511
NP_492458.1 Protein PYK-1, isoform a C. elegans 72.0 561
XP_001728254.1 pyruvate kinase, variant N. crassa 64.1 526
NP_009362.1 pyruvate kinase CDC19 S. cerevisiae 64.1 484
XP_001693008.1 pyruvate kinase C. reinhardtii 62.2 489
NP_201173.1 pyruvate kinase A. thaliana 62.1 496
Other hits (2 of 61) [Show all]SpeciesId(%)Len(aa)
XP_002727490.1 PREDICTED: pyruvate kinase isozymes M1/M2-like isoform 1 R. norvegicus 99.4 530
NP_001137266.1 PKM gene product E. caballus 99.4 530

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; skin; kidney; testis; uncharacterized tissue; lung; pancreas; intestine; ovary; uterus; eye; connective tissue; prostate; embryonic tissue; liver; placenta; lymph; mammary gland; muscle; ascites; blood; cervix; mouth; heart; stomach; vascular; bone; thymus; spleen; salivary gland; mixed; thyroid; adrenal gland; bone marrow; tonsil; lymph node; trachea; bladder; esophagus; umbilical cord; larynx; pharynx; pineal gland; pituitary gland; amniotic fluid; nerve; ganglia; epididymis; spinal cord; adipose tissue; parathyroid; peritoneum; ear
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 15
Map position: 15q22
UniSTS entry: Chr 15 RH67936
UniSTS entry: Chr 15 GDB:451703
UniSTS entry: Chr 6 RH69107
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (32)

M23725.1 Human M2-type pyruvate kinase mRNA, complete cds P
M26252.1 Human TCB gene encoding cytosolic thyroid hormone-binding protein, complete cds P
NM_182471.2 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 3, mRNA PA
NM_182470.2 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 2, mRNA PA
BX648597.1 Homo sapiens mRNA; cDNA DKFZp686G12209 (from clone DKFZp686G12209) PA
NM_002654.4 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 1, mRNA PA
AK222927.1 Homo sapiens mRNA for pyruvate kinase 3 isoform 1 variant, clone: HRC08174 P
BC094767.1 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:104654 IMAGE:5296639), complete cds PA
BC096823.1 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:30558692) PA
BC000481.2 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:8698 IMAGE:2964687), complete cds PA
BC007952.2 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:14360 IMAGE:4299213), complete cds PA
BC007640.1 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:15908 IMAGE:3533876), complete cds PA
BC012811.2 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:3932 IMAGE:2958817), complete cds PA
BC019265.2 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:3503708), partial cds PA
AK308264.1 Homo sapiens cDNA, FLJ98212 P
AK307855.1 Homo sapiens cDNA, FLJ97803 P
AK309781.1 Homo sapiens cDNA, FLJ99822 P
AK312253.1 Homo sapiens cDNA, FLJ92548, highly similar to Homo sapiens pyruvate kinase, muscle (PKM2), mRNA P
AK092369.1 Homo sapiens cDNA FLJ35050 fis, clone OCBBF2018167, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40) P
AK294315.1 Homo sapiens cDNA FLJ56065 complete cds, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40) P
AK300800.1 Homo sapiens cDNA FLJ54554 complete cds, highly similar to Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) P
AK297951.1 Homo sapiens cDNA FLJ53368 complete cds, highly similar to Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) P
AK299413.1 Homo sapiens cDNA FLJ53645 complete cds, highly similar to Pyruvate kinase isozyme M1 (EC 2.7.1.40) PA
BC023592.2 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:4646848) PA
BC023328.1 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone IMAGE:4510296) PA
Z36831.1 H.sapiens (xs25) mRNA, 443bp P
BC035198.1 Homo sapiens pyruvate kinase, muscle, mRNA (cDNA clone MGC:9369 IMAGE:3859987), complete cds PA
NM_001206799.1 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 7, mRNA PA
NM_001206798.1 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 6, mRNA PA
NM_001206797.1 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 5, mRNA PA
NM_001206796.1 Homo sapiens pyruvate kinase, muscle (PKM), transcript variant 4, mRNA PA
AF025439.1 Homo sapiens Opa-interacting protein OIP3 mRNA, partial cds PA

EST sequences (10 of 9988) [Show all sequences]

AA954688.1 Clone IMAGE:1554958 kidney 3' read A
AA961352.1 Clone IMAGE:1599484 uncharacterized tissue 3' read A
AA975644.1 Clone IMAGE:1591011 kidney 3' read A
AA976397.1 Clone IMAGE:1591526 kidney 3' read A
AA987302.1 Clone IMAGE:1602296 lung 3' read A
AI000757.1 Clone IMAGE:1613145 uncharacterized tissue 3' read A
AI015272.1 Clone IMAGE:1641224 testis 3' read A
AI033722.1 Clone IMAGE:1663478 skin 3' read
AI039372.1 Clone IMAGE:1658763 embryonic tissue 3' read A
AI039872.1 Clone IMAGE:1664258 skin 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help