> Interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST)
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UGID:1271980     UniGene Hs.532082     Homo sapiens (human)   IL6ST Order cDNA clone, Links
Interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST)

Human protein-coding gene IL6ST. Represented by 622 ESTs from 262 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 1271980 - Hs.532082]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002175.2 IL6ST gene product H. sapiens 100.0 917
XP_001144416.1 PREDICTED: interleukin-6 receptor subunit beta isoform 2 P. troglodytes 99.9 917
NP_034690.3 Il6st gene product M. musculus 84.6 910
NP_001124412.1 interleukin 6 signal transducer (gp130, oncostatin M receptor) precursor X. laevis 54.5 665
NP_001106976.1 il6st gene product D. rerio 53.1 256
Other hits (2 of 16) [Show all]SpeciesId(%)Len(aa)
XP_001100601.1 PREDICTED: interleukin-6 receptor subunit beta isoform 1 M. mulatta 98.8 917
XP_003899735.1 PREDICTED: interleukin-6 receptor subunit beta isoform 1 P. anubis 98.8 917

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; placenta; mixed; uterus; liver; testis; trachea; pituitary gland; bone; bladder; pancreas; embryonic tissue; uncharacterized tissue; adrenal gland; kidney; thymus; eye; mammary gland; connective tissue; ear; skin; prostate; intestine; lung; vascular; muscle; blood; spleen; parathyroid; ovary; thyroid; stomach; heart; larynx; pharynx; cervix; ascites; nerve; lymph node; bone marrow; spinal cord; ganglia; tonsil
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5q11.2
UniSTS entry: Chr 5 RH15643 [Map Viewer]
UniSTS entry: Chr 17 D17S58
UniSTS entry: Chr 17 GDB:353576
UniSTS entry: Chr 5 D5S2597 [Map Viewer]
UniSTS entry: Chr 5 RH15655 [Map Viewer]
UniSTS entry: Chr 5 RH17700
UniSTS entry: Chr 5 SHGC-58193
UniSTS entry: Chr 5 G24196
UniSTS entry: Chr 17 GDB:592062
UniSTS entry: GDB:353575
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (17)

AL049265.1 Homo sapiens mRNA; cDNA DKFZp564F053 (from clone DKFZp564F053) A
NM_175767.2 Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 2, mRNA PA
AB015706.1 Homo sapiens mRNA for gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form (gp130-RAPS), complete cds P
NM_002184.3 Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mRNA PA
BC071555.1 Homo sapiens cDNA clone IMAGE:4374041, containing frame-shift errors PA
AB102804.1 Homo sapiens IL6ST mRNA for IL6ST nirs variant 6, complete cds
AB102802.1 Homo sapiens IL6ST mRNA for IL6ST nirs variant 4, complete cds P
AB102801.1 Homo sapiens IL6ST mRNA for IL6ST nirs variant 3, complete cds P
AB102799.1 Homo sapiens IL6ST mRNA for IL6ST nirs variant 1, complete cds
M57230.1 Human membrane glycoprotein gp130 mRNA, complete cds P
AB074172.1 Homo sapiens primary neuroblastoma cDNA, clone:Nbla10111, full insert sequence A
BC117402.1 Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor), mRNA (cDNA clone MGC:151011 IMAGE:40125953), complete cds P
BC117404.1 Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor), mRNA (cDNA clone MGC:151013 IMAGE:40125955), complete cds P
BC143842.1 Homo sapiens cDNA clone IMAGE:9052357, with apparent retained intron P
NM_001190981.1 Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 3, mRNA P
S80479.1 gp130=LIF receptor/IL-6 receptor complex component {alternatively spliced} [human, preimplantation embryos, blastocysts, mRNA Partial, 150 nt]
U58146.1 Homo sapiens alternatively spliced interleukin-6 receptor beta chain mRNA, partial cds

EST sequences (10 of 622) [Show all sequences]

AA954396.1 Clone IMAGE:1564926 mixed 3' read P
AA962114.1 Clone IMAGE:1600294 uncharacterized tissue 3' read A
AA989391.1 Clone IMAGE:1606172 kidney 3' read A
AA992163.1 Clone IMAGE:1623049 embryonic tissue 3' read
AA992164.1 Clone IMAGE:1623053 embryonic tissue 3' read A
AA906545.1 Clone IMAGE:1524043 mixed 3' read
AA909654.1 Clone IMAGE:1523485 mixed 3' read A
AI018693.1 Clone IMAGE:1641954 testis 3' read P
AI040399.1 Clone IMAGE:1646377 parathyroid 3' read A
AI040573.1 Clone IMAGE:1656363 mixed 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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