Steroidogenic acute regulatory protein (STAR)

Restricted Expression:

adrenal gland [show more like this]

adrenal tumor [show more like this]

infant [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

adrenal gland; brain; testis; uncharacterized tissue; muscle; embryonic tissue; ovary; placenta; kidney; lung; mixed; eye; mammary gland; salivary gland; skin; uterus

NCBI

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Finding cDNAs

UGID:912282 UniGene Hs.521535 Homo sapiens (human) STAR

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Steroidogenic acute regulatory protein (STAR)

Human protein-coding gene STAR. Represented by 627 ESTs from 66 cDNA libraries. EST representation biased toward adrenal gland; adrenal tumor; infant. Corresponds to reference sequence NM_000349.2. [UniGene 912282 - Hs.521535]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_001170375.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: steroidogenic acute regulatory protein, mitochondrial isoform 6	P. troglodytes	100.0	284
NP_000340.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	STAR gene product	H. sapiens	100.0	284
NP_035615.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Star gene product	M. musculus	89.8	283
NP_001089945.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	uncharacterized protein LOC735015	X. laevis	76.8	284
NP_571738.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	star gene product	D. rerio	68.5	283
Other hits (2 of 20) [Show all]		Species	Id(%)	Len(aa)
XP_003902701.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: steroidogenic acute regulatory protein, mitochondrial	P. anubis	99.0	284
XP_001090472.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: steroidogenic acute regulatory protein, mitochondrial isoform 3	M. mulatta	98.6	284

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	8
Map position:	8p11.2
UniSTS entry:	Chr 13	G15988
UniSTS entry:	Chr 8	SGC31588	[Map Viewer]
UniSTS entry:	Chr 13	D8S2291
UniSTS entry:	Chr 1	GDB:434012
UniSTS entry:	Chr 8	STAR_2298

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

NM_000349.2	Homo sapiens steroidogenic acute regulatory protein (STAR), nuclear gene encoding mitochondrial protein, mRNA	P
AY532319.1	Homo sapiens steroid acute regulatory protein (STAR) mRNA, partial cds
CR456803.1	Homo sapiens full open reading frame cDNA clone RZPDo834B0219D for gene STAR, steroidogenic acute regulatory protein; complete cds, incl. stopcodon	P
CR541850.1	Homo sapiens full open reading frame cDNA clone RZPDo834F0332D for gene STAR, steroidogenic acute regulatory protein; complete cds, without stopcodon	P
S79669.1	steroidogenic acute regulatoy protein [human, follicle cells, mRNA, 1641 nt]	PA
BC010550.1	Homo sapiens steroidogenic acute regulatory protein, mRNA (cDNA clone MGC:17170 IMAGE:4153601), complete cds	PA
AK315122.1	Homo sapiens cDNA, FLJ96085, highly similar to Homo sapiens steroidogenic acute regulator (STAR), mRNA	P
U17280.1	Human steroidogenic acute regulatory protein (StAR) mRNA, complete cds	P
AF035277.1	Homo sapiens clone 23875 steroidogenic acute regulatory protein mRNA, complete cds	PA

EST sequences (10 of 627) [Show all sequences]

AI015885.1	Clone IMAGE:1622621	embryonic tissue	3' read	A
T27012.1	Clone LLAB132A10	brain	3' read	A
T27013.1	Clone LLAB132A10	brain	5' read
AI076596.1	Clone IMAGE:1676908	embryonic tissue	3' read	A
AI192614.1	Clone IMAGE:1743978	lung	3' read	A
AI206358.1	Clone IMAGE:1758300	placenta	3' read	A
AI208456.1	Clone IMAGE:1837257	testis	3' read	A
AI200533.1	Clone IMAGE:1757594	placenta	3' read	A
AI204590.1	Clone IMAGE:1734906	testis	3' read	A
AI333821.1	Clone IMAGE:1930605	lung	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria