Serine/threonine kinase 11 (STK11)

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UGID:905752 UniGene Hs.515005 Homo sapiens (human) STK11

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Serine/threonine kinase 11 (STK11)

Human protein-coding gene STK11. Represented by 351 ESTs from 152 cDNA libraries. Corresponds to reference sequence NM_000455.4. [UniGene 905752 - Hs.515005]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_001093806.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: serine/threonine-protein kinase 11	M. mulatta	100.0	432
XP_003914621.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: serine/threonine-protein kinase STK11	P. anubis	100.0	432
NP_000446.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	STK11 gene product	H. sapiens	100.0	432
XP_524028.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: serine/threonine-protein kinase STK11	P. troglodytes	99.8	432
NP_035622.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Stk11 gene product	M. musculus	96.1	435
NP_001083758.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	serine/threonine-protein kinase stk11	X. laevis	92.3	429
NP_001017839.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	stk11 gene product	D. rerio	91.7	434
NP_650302.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lkb1, isoform B	D. melanogaster	67.1	453
NP_001256780.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein PAR-4, isoform b	C. elegans	49.3	274
Other hits (2 of 34) [Show all]		Species	Id(%)	Len(aa)
XP_542206.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: serine/threonine-protein kinase STK11	C. lupus familiaris	97.0	438
XP_004008823.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: serine/threonine-protein kinase STK11	O. aries	96.8	437

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	uncharacterized tissue; brain; testis; mixed; lung; pancreas; prostate; eye; mouth; kidney; embryonic tissue; intestine; ovary; mammary gland; lymph; uterus; lymph node; bone marrow; cervix; stomach; skin; trachea; placenta; tonsil; bladder; salivary gland; muscle; ascites; connective tissue; blood; thyroid; bone; larynx; thymus; umbilical cord; nerve

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	19
Map position:	19p13.3
UniSTS entry:	Chr 19	RH104368

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

NM_000455.4	Homo sapiens serine/threonine kinase 11 (STK11), mRNA	PA
AJ844634.2	Homo sapiens partial mRNA for serine/threonine kinase 11 (STK11 gene)	P
AF217978.1	Homo sapiens clone PP1471 unknown mRNA	PA
BC007981.2	Homo sapiens serine/threonine kinase 11, mRNA (cDNA clone MGC:16254 IMAGE:3689780), complete cds	PA
EF644172.1	Homo sapiens polarization-related protein LKB1 mRNA, complete cds	P
BC019334.1	Homo sapiens serine/threonine kinase 11, mRNA (cDNA clone MGC:12715 IMAGE:3946005), complete cds	PA
AK314858.1	Homo sapiens cDNA, FLJ95757, Homo sapiens serine/threonine kinase 11 (Peutz-Jeghers syndrome)(STK11), mRNA	PA
GU573916.1	Homo sapiens serine/threonine kinase 11 (STK11) mRNA, partial cds
U63333.1	Human serine/threonine protein kinase (LKB1) mRNA, complete cds	P
AF035625.1	Homo sapiens serine threonine kinase 11 (STK11) mRNA, complete cds	P

EST sequences (10 of 351) [Show all sequences]

AA954690.1	Clone IMAGE:1554941	kidney	3' read
AA993755.1	Clone IMAGE:1621659	testis	3' read
AA928035.1	Clone IMAGE:1541975	mixed	3' read
AI055947.1	Clone IMAGE:1659185	embryonic tissue	3' read
CB047826.1	Clone IMAGE:3270478	prostate	3' read	A
CB047827.1	Clone IMAGE:3270478	prostate	5' read	A
AI185883.1	Clone IMAGE:1741915	lung	3' read
AI206409.1	Clone IMAGE:1761755	kidney	3' read
AI218621.1	Clone IMAGE:1753738	testis	3' read
AI251127.1	Clone IMAGE:2004773	pancreas	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria