> Granulin (GRN)
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UGID:904967     UniGene Hs.514220     Homo sapiens (human)   GRN Order cDNA clone, Links
Granulin (GRN)

Human protein-coding gene GRN. Represented by 6877 ESTs from 591 cDNA libraries. EST representation biased toward neonate. Corresponds to reference sequence NM_002087.2. [UniGene 904967 - Hs.514220]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002078.1 GRN gene product H. sapiens 100.0 592
NP_032201.2 Grn gene product M. musculus 81.9 601
NP_492982.1 Protein PGRN-1, isoform b C. elegans 55.0 149
NP_001085281.1 uncharacterized protein LOC443608 precursor X. laevis 54.0 715
NP_997903.1 grnb gene product D. rerio 52.7 715
Other hits (2 of 26) [Show all]SpeciesId(%)Len(aa)
XP_511549.2 PREDICTED: granulins P. troglodytes 99.0 500
XP_002808178.1 PREDICTED: LOW QUALITY PROTEIN: granulins-like M. mulatta 95.8 592

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; connective tissue; placenta; blood; lung; spleen; intestine; kidney; testis; uterus; skin; prostate; mammary gland; thymus; ascites; ovary; vascular; liver; pancreas; stomach; mouth; heart; mixed; thyroid; trachea; adrenal gland; bladder; cervix; eye; embryonic tissue; esophagus; umbilical cord; salivary gland; bone; muscle; bone marrow; lymph node; lymph; pituitary gland; amniotic fluid; tonsil; nerve; ear; ganglia; parathyroid; larynx; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q21.32
UniSTS entry: Chr 17 G54019
UniSTS entry: Chr 17 D17S1701
UniSTS entry: Chr 17 STS-T54360 [Map Viewer]
UniSTS entry: Chr 17 STS-X62320 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

BT006844.1 Homo sapiens granulin mRNA, complete cds P
NM_002087.2 Homo sapiens granulin (GRN), mRNA PA
AK000607.1 Homo sapiens cDNA FLJ20600 fis, clone KAT07521, highly similar to AF055008 Homo sapiens clone 24720 epithelin 1 and 2 mRNA PA
AK222522.1 Homo sapiens mRNA for granulin variant, clone: adSE02012 PA
M75161.1 H.sapiens granulin mRNA, complete cds P
AK023348.1 Homo sapiens cDNA FLJ13286 fis, clone OVARC1001154, highly similar to Homo sapiens clone 24720 epithelin 1 and 2 mRNA P
BC000324.2 Homo sapiens granulin, mRNA (cDNA clone MGC:8480 IMAGE:2821810), complete cds PA
BC010577.2 Homo sapiens granulin, mRNA (cDNA clone MGC:9342 IMAGE:3457813), complete cds PA
BC127696.1 Homo sapiens cDNA clone IMAGE:40127982 P
AY124489.1 Homo sapiens PC cell-derived growth factor (GRN) mRNA, complete cds PA
X62320.1 H.sapiens mRNA for epithelin 1 and 2 PA
AK303830.1 Homo sapiens cDNA FLJ53692 complete cds, moderately similar to Granulins precursor P
AK296090.1 Homo sapiens cDNA FLJ53342 complete cds, highly similar to Granulins precursor P
AF055008.1 Homo sapiens clone 24720 epithelin 1 and 2 mRNA, complete cds PA

EST sequences (10 of 6877) [Show all sequences]

AA954971.1 Clone IMAGE:1577776 mixed 3' read A
AA961105.1 Clone IMAGE:1569793 lung 3' read A
AA864802.1 Clone IMAGE:1456659 kidney 3' read A
AA962413.1 Clone IMAGE:1570005 lung 3' read
AA976440.1 Clone IMAGE:1589877 kidney 3' read A
AA977760.1 Clone IMAGE:1590662 kidney 3' read
AI024151.1 Clone IMAGE:1642931 testis 3' read A
AI038232.1 Clone IMAGE:1663932 skin 3' read A
AI038236.1 Clone IMAGE:1663921 skin 3' read A
AI038888.1 Clone IMAGE:1663074 skin 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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