> Actinin, alpha 1 (ACTN1)
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UGID:724924     UniGene Hs.509765     Homo sapiens (human)   ACTN1 Order cDNA clone, Links
Actinin, alpha 1 (ACTN1)

Human protein-coding gene ACTN1. Represented by 1785 ESTs from 481 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 724924 - Hs.509765]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001123476.1 ACTN1 gene product H. sapiens 100.0 913
XP_003902014.1 PREDICTED: alpha-actinin-1-like isoform 4 P. anubis 99.9 929
XP_003364083.1 PREDICTED: alpha-actinin-1-like isoform 3 E. caballus 99.9 921
XP_853103.1 PREDICTED: alpha-actinin-1 isoform 1 C. lupus familiaris 99.9 913
XP_002719567.1 PREDICTED: actinin, alpha 1-like isoform 1 O. cuniculus 99.9 913
NP_598917.1 Actn1 gene product M. musculus 99.9 891
NP_112267.1 Actn1 gene product R. norvegicus 99.9 891
NP_001030428.1 ACTN1 gene product B. taurus 99.9 891
NP_001229990.1 ACTN1 gene product S. scrofa 99.9 886
XP_004011102.1 PREDICTED: LOW QUALITY PROTEIN: alpha-actinin-1 O. aries 99.7 860
NP_001161758.1 actn1 gene product D. rerio 97.3 899
NP_001084298.1 actinin, alpha 1 X. laevis 96.5 889
NP_477484.2 alpha actinin, isoform A D. melanogaster 79.4 893
NP_001119159.1 60S ribosomal protein L4-2 A. thaliana 77.2 114
XP_001694804.1 ribosomal protein L4, component of cytosolic 80S ribosome and 60S large subunit C. reinhardtii 75.4 122
NP_010295.3 ribosomal 60S subunit protein L4B S. cerevisiae 74.0 119
NP_506128.1 Protein ATN-1, isoform b C. elegans 72.8 893
XP_957320.1 hypothetical protein NCU06429 N. crassa 54.4 296
Other hits (2 of 58) [Show all]SpeciesId(%)Len(aa)
XP_002199408.1 PREDICTED: actinin, alpha 1 T. guttata 99.4 880
NP_989458.1 ACTN1 gene product G. gallus 99.1 885

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; testis; uterus; skin; lung; intestine; kidney; uncharacterized tissue; placenta; pancreas; mammary gland; connective tissue; liver; mixed; prostate; mouth; eye; blood; thymus; adrenal gland; trachea; stomach; bladder; ovary; bone; vascular; muscle; spleen; heart; lymph node; thyroid; cervix; adipose tissue; salivary gland; amniotic fluid; bone marrow; parathyroid; umbilical cord; larynx; nerve; ganglia; ear; ascites; esophagus; pharynx; epididymis; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 14
Map position: 14q24|14q22-q24
UniSTS entry: Chr 14 Actn1
UniSTS entry: Chr 14 D14S1222
UniSTS entry: Chr 14 D14S1312
UniSTS entry: Chr 14 MARC_17931-17932:1024341335:5
UniSTS entry: Chr 1 D10S275
UniSTS entry: Chr 2 ECD17402
UniSTS entry: Chr 7 STS-D29544 [Map Viewer]
UniSTS entry: Chr 1 D8S2279
UniSTS entry: Chr 1 D15S1477
UniSTS entry: Chr 1 ACTN2
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (25)

BX248020.1 human full-length cDNA clone CS0DB009YA03 of Neuroblastoma of Homo sapiens (human) P
BT007207.1 Homo sapiens actinin, alpha 1 mRNA, complete cds P
BX641076.1 Homo sapiens mRNA; cDNA DKFZp686J22226 (from clone DKFZp686J22226) PA
AK124378.1 Homo sapiens cDNA FLJ42387 fis, clone UTERU2037791, highly similar to Human mRNA for alpha-actinin P
NM_001102.3 Homo sapiens actinin, alpha 1 (ACTN1), transcript variant 2, mRNA PA
M95178.1 Human non-muscle alpha-actinin mRNA, complete cds P
AJ844628.2 Homo sapiens partial mRNA for alpha-actinin 1 (ACTN1 gene) P
AK022224.1 Homo sapiens cDNA FLJ12162 fis, clone MAMMA1000583
DQ496098.1 Homo sapiens actinin alpha 1 isoform b (ACTN1) mRNA, complete cds, alternatively spliced P
BC003576.1 Homo sapiens actinin, alpha 1, mRNA (cDNA clone MGC:2358 IMAGE:3547017), complete cds PA
AK225782.1 Homo sapiens mRNA for actinin, alpha 1 variant, clone: FCC132A11 PA
BC127124.1 Homo sapiens actinin, alpha 1, mRNA (cDNA clone IMAGE:40009911), partial cds P
BC015766.1 Homo sapiens actinin, alpha 1, mRNA (cDNA clone MGC:23191 IMAGE:4856734), complete cds PA
X15804.1 Human mRNA for alpha-actinin P
X55187.1 Human mRNA for alpha-actinin, partial cds P
EU716325.1 Homo sapiens actinin 1 smooth muscle variant (ACTN1) mRNA, complete cds, alternatively spliced P
AK098203.1 Homo sapiens cDNA FLJ40884 fis, clone UTERU2000607, highly similar to Alpha-actinin-1 P
NM_001130005.1 Homo sapiens actinin, alpha 1 (ACTN1), transcript variant 3, mRNA PA
NM_001130004.1 Homo sapiens actinin, alpha 1 (ACTN1), transcript variant 1, mRNA PA
AK294317.1 Homo sapiens cDNA FLJ53313 complete cds, highly similar to Alpha-actinin-1 P
AK299362.1 Homo sapiens cDNA FLJ54718 complete cds, highly similar to Alpha-actinin-1 P
AK295099.1 Homo sapiens cDNA FLJ59209 complete cds, highly similar to Alpha-actinin-1 P
FJ410030.1 Homo sapiens actinin alpha 1 isoform 3 (ACTN1) mRNA, complete cds, alternatively spliced P
BC004984.1 Homo sapiens cDNA clone IMAGE:2958601, containing frame-shift errors PA
AK298496.1 Homo sapiens cDNA FLJ54739 complete cds, highly similar to Alpha-actinin-1 P

EST sequences (10 of 1785) [Show all sequences]

AA973595.1 Clone IMAGE:1569334 lung 3' read A
AI002062.1 Clone IMAGE:1613269 uncharacterized tissue 3' read A
AI018491.1 Clone IMAGE:1642031 testis 3' read A
AI038818.1 Clone IMAGE:1664178 skin 3' read A
AI041634.1 Clone IMAGE:1663833 skin 3' read P
AI041757.1 Clone IMAGE:1664525 skin 3' read P
AI082078.1 Clone IMAGE:1679010 skin 3' read A
AI094021.1 Clone IMAGE:1688074 mixed 3' read A
AI123560.1 Clone IMAGE:1690149 mixed 3' read A
AI125716.1 Clone IMAGE:1737228 testis 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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