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UGID:719162     UniGene Hs.504003     Homo sapiens (human)   BACE1 Order cDNA clone, Links
Beta-site APP-cleaving enzyme 1 (BACE1)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
XP_001094263.1 PREDICTED: beta-site APP-cleaving enzyme 1 isoform 5 M. mulatta 100.0 500
XP_001158428.1 PREDICTED: beta-site APP-cleaving enzyme 1 isoform 6 P. troglodytes 100.0 500
NP_036236.1 beta-site APP-cleaving enzyme 1 isoform A preproprotein H. sapiens 100.0 500
XP_546508.2 PREDICTED: similar to Beta-secretase 1 precursor (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Aspartyl protease 2) (Asp 2) (ASP2) (Membrane-associated aspartic protease 2) (Memapsin-2) C. lupus familiaris 99.8 425
NP_001039996.1 beta-site APP-cleaving enzyme 1 precursor B. taurus 99.6 500
NP_035922.4 beta-site APP cleaving enzyme 1 isoform 1 M. musculus 99.2 500
NP_991267.1 beta-site APP-cleaving enzyme 1 D. rerio 84.7 477
NP_001080615.1 beta-site APP-cleaving enzyme 2 X. laevis 53.4 461

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; skin; eye; larynx; lung; uncharacterized tissue; esophagus; muscle; liver; ovary; pancreas; vascular; prostate; testis; parathyroid; mouth; kidney; uterus; placenta; connective tissue; embryonic tissue; thyroid; bone marrow; ear; salivary gland; heart; bone; intestine; mammary gland; cervix; spinal cord; blood; stomach; adrenal gland; epididymis; ganglia; pituitary gland; pineal gland; pharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11q23.2-q23.3
UniSTS entry: Chr 11 G20259
UniSTS entry: Chr 11 A005A12
UniSTS entry: Chr 11 D11S2294E
UniSTS entry: Chr 11 RH12629
UniSTS entry: Chr 11 G32977
UniSTS entry: Chr 11 A009Y15
UniSTS entry: Chr 11 WI-14206
UniSTS entry: Chr 11 IB1111
UniSTS entry: Chr 11 WI-15498
UniSTS entry: Chr 11 D11S2298E
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (26)

AB089958.1 Homo sapiens BACE mRNA for beta-site APP cleaving enzyme isoform I-127, complete cds P
NM_012104.3 Homo sapiens beta-site APP-cleaving enzyme 1 (BACE1), transcript variant a, mRNA PA
BC065492.1 Homo sapiens beta-site APP-cleaving enzyme 1, mRNA (cDNA clone MGC:71162 IMAGE:6538154), complete cds PA
AB032975.2 Homo sapiens mRNA for KIAA1149 protein, partial cds P
AB177847.1 Homo sapiens mRNA for KIAA1149 splice variant 1 P
AF190725.1 Homo sapiens beta-site APP cleaving enzyme (BACE) mRNA, complete cds PA
AF200343.1 Homo sapiens chromosome 11 aspartyl protease 2 mRNA, complete cds PA
AF201468.1 Homo sapiens APP beta-secretase mRNA, complete cds PA
AF204943.1 Homo sapiens transmembrane aspartic proteinase Asp 2 (BACE1) mRNA, complete cds P
AF161367.1 Homo sapiens HSPC104 mRNA, partial cds P
AF200193.1 Homo sapiens memapsin 2 mRNA, partial cds PA
AF338817.1 Homo sapiens beta-site APP cleaving enzyme type C mRNA, complete cds P
AF338816.1 Homo sapiens beta-site APP cleaving enzyme type B mRNA, complete cds P
AB050438.1 Homo sapiens BACE mRNA for beta-site APP cleaving enzyme I-432, complete cds P
AB050437.1 Homo sapiens BACE mRNA for beta-site APP cleaving enzyme I-457, complete cds P
AB050436.1 Homo sapiens BACE mRNA for beta-site APP cleaving enzyme I-476, complete cds P
NM_138973.2 Homo sapiens beta-site APP-cleaving enzyme 1 (BACE1), transcript variant d, mRNA PA
NM_138972.2 Homo sapiens beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b, mRNA PA
NM_138971.2 Homo sapiens beta-site APP-cleaving enzyme 1 (BACE1), transcript variant c, mRNA PA
AL833810.1 Homo sapiens mRNA; cDNA DKFZp564D083 (from clone DKFZp564D083) A
AK075049.1 Homo sapiens cDNA FLJ90568 fis, clone OVARC1001570, highly similar to Beta-secretase 1 precursor (EC 3.4.23.46) P
AF527782.1 Homo sapiens beta-site APP-cleaving enzyme (BACE) mRNA, partial cds, alternatively spliced P
AF324837.1 Homo sapiens beta-site APP cleaving enzyme mRNA, partial cds, alternatively spliced
AK296535.1 Homo sapiens cDNA FLJ54693 complete cds, highly similar to Beta-secretase 1 precursor (EC 3.4.23.46) P
AK296015.1 Homo sapiens cDNA FLJ54690 complete cds, highly similar to Beta-secretase 1 precursor (EC 3.4.23.46) P
BC036084.1 Homo sapiens beta-site APP-cleaving enzyme 1, mRNA (cDNA clone MGC:33762 IMAGE:5311572), complete cds PA

EST sequences (10 of 530) [Show all sequences]

AA954460.1 Clone IMAGE:1562299 mixed 3' read
AA864263.1 Clone IMAGE:1460208 kidney 3' read A
R14536.1 Clone IMAGE:29111 brain 5' read
AA970909.1 Clone IMAGE:1572680 kidney 3' read A
AA973564.1 Clone IMAGE:1569253 lung 3' read
AI005033.1 Clone IMAGE:1635167 kidney 3' read
AI027143.1 Clone IMAGE:1649446 parathyroid 3' read A
AA922033.1 Clone IMAGE:1543958 mixed 3' read
AI040286.1 Clone IMAGE:1665310 skin 3' read
AI040388.1 Clone IMAGE:1656487 mixed 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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