> Actin, alpha 2, smooth muscle, aorta (ACTA2)
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UGID:715642     UniGene Hs.500483     Homo sapiens (human)   ACTA2 Order cDNA clone, Links
Actin, alpha 2, smooth muscle, aorta (ACTA2)

Human protein-coding gene ACTA2. Represented by 1513 ESTs from 372 cDNA libraries. EST representation biased toward neonate. Corresponds to 2 reference sequences (different isoforms). [UniGene 715642 - Hs.500483]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_031418.1 Acta2 gene product M. musculus 100.0 376
NP_112266.1 Acta2 gene product R. norvegicus 100.0 376
XP_003224414.1 PREDICTED: actin, aortic smooth muscle-like A. carolinensis 100.0 376
XP_003962565.1 PREDICTED: actin, alpha skeletal muscle B-like isoform 1 T. rubripes 100.0 376
NP_001142321.1 uncharacterized protein LOC100274491 Z. mays 100.0 376
NP_997785.1 acta2 gene product D. rerio 100.0 376
XP_004084707.1 PREDICTED: actin, alpha skeletal muscle B-like isoform 1 O. latipes 100.0 376
XP_003449459.1 PREDICTED: actin, alpha skeletal muscle B-like isoform 1 O. niloticus 100.0 376
NP_001084806.1 actin, alpha 2, smooth muscle, aorta X. laevis 100.0 376
NP_001011250.1 acta2 gene product X. tropicalis 100.0 376
NP_001026400.1 ACTA2 gene product G. gallus 100.0 376
XP_003208069.1 PREDICTED: actin, aortic smooth muscle-like M. gallopavo 100.0 376
XP_002805789.1 PREDICTED: actin, aortic smooth muscle-like isoform 2 M. mulatta 100.0 376
XP_003904017.1 PREDICTED: actin, aortic smooth muscle P. anubis 100.0 376
XP_001141780.1 PREDICTED: actin, aortic smooth muscle isoform 3 P. troglodytes 100.0 376
NP_001135417.1 ACTA2 gene product H. sapiens 100.0 376
XP_534781.2 PREDICTED: actin, aortic smooth muscle isoform 2 C. lupus familiaris 100.0 376
XP_001503085.1 PREDICTED: actin, aortic smooth muscle isoform 1 E. caballus 100.0 376
NP_001158122.1 ACTA2 gene product S. scrofa 100.0 376
NP_001029674.1 ACTA2 gene product B. taurus 100.0 376
XP_004020068.1 PREDICTED: actin, aortic smooth muscle isoform 1 O. aries 100.0 376
NP_001095152.1 ACTA2 gene product O. cuniculus 100.0 376
XP_001370562.1 PREDICTED: actin, alpha cardiac muscle 1-like isoform 1 M. domestica 99.7 376
XP_002200536.1 PREDICTED: actin, alpha cardiac muscle 1 T. guttata 99.7 376
NP_001188195.1 actin alpha sarcomeric/cardiac I. punctatus 99.7 376
NP_001133115.1 fast myotomal muscle actin 2 S. salar 99.7 376
NP_505818.1 Protein ACT-2 C. elegans 97.1 375
NP_511052.1 actin 5C, isoform B D. melanogaster 96.8 375
XP_001699068.1 actin C. reinhardtii 93.9 376
NP_187818.1 actin-11 A. thaliana 92.6 376
NP_116614.1 actin S. cerevisiae 91.2 374
XP_961133.2 actin N. crassa 90.7 374
Other hits (2 of 46) [Show all]SpeciesId(%)Len(aa)
XP_001507188.1 PREDICTED: actin, alpha skeletal muscle-like isoform 1 O. anatinus 99.2 376
XP_002132052.1 PREDICTED: similar to CsMA-1 isoform 2 C. intestinalis 98.9 376

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uterus; lung; intestine; prostate; stomach; pancreas; vascular; brain; connective tissue; placenta; uncharacterized tissue; eye; umbilical cord; kidney; testis; bone marrow; mixed; mammary gland; skin; bone; adipose tissue; muscle; spleen; ovary; heart; liver; embryonic tissue; blood; nerve; bladder; trachea; pharynx; thyroid; adrenal gland; thymus; ganglia; amniotic fluid; esophagus; cervix; epididymis; spinal cord; pituitary gland; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q23.3
UniSTS entry: Chr 10 D10S2177
UniSTS entry: Chr 10 RH44176 [Map Viewer]
UniSTS entry: Chr 10 ACTA2_(5)
UniSTS entry: Chr 15 PMC23952P1
UniSTS entry: Chr 10 RH45184 [Map Viewer]
UniSTS entry: Chr 10 GDB:193855
UniSTS entry: Chr 7 ACTB-L
UniSTS entry: Chr 1 D3S1674
UniSTS entry: Acta1
UniSTS entry: Chr 1 PMC305873P2
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

BX647362.1 Homo sapiens mRNA; cDNA DKFZp686P1462 (from clone DKFZp686P1462) A
AK127229.1 Homo sapiens cDNA FLJ45296 fis, clone BRHIP3003340
NM_001613.2 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA PA
J05192.1 Human alpha-actin (ACTA) mRNA, complete cds P
CR536518.1 Homo sapiens full open reading frame cDNA clone RZPDo834A1120D for gene ACTA2, actin, alpha 2, smooth muscle, aorta; complete cds, incl. stopcodon P
BC093052.1 Homo sapiens actin, alpha 2, smooth muscle, aorta, mRNA (cDNA clone MGC:111131 IMAGE:30351093), complete cds PA
AK025094.1 Homo sapiens cDNA: FLJ21441 fis, clone COL04422 A
AY692464.1 Homo sapiens growth-inhibiting gene 46 mRNA, complete cds PA
BC017554.2 Homo sapiens actin, alpha 2, smooth muscle, aorta, mRNA (cDNA clone MGC:9221 IMAGE:3906861), complete cds PA
AK313294.1 Homo sapiens cDNA, FLJ93806, Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), mRNA P
X13839.1 Human mRNA for vascular smooth muscle alpha-actin P
AK300664.1 Homo sapiens cDNA FLJ52761 complete cds, highly similar to Actin, aortic smooth muscle PA
NM_001141945.1 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 1, mRNA PA
AK300353.1 Homo sapiens cDNA FLJ52755 complete cds, highly similar to Actin, aortic smooth muscle P

EST sequences (10 of 1513) [Show all sequences]

AA865183.1 Clone IMAGE:1459102 kidney 3' read A
AA864475.1 Clone IMAGE:1460102 kidney 3' read PA
AA968827.1 Clone IMAGE:1570043 lung 3' read PA
AA970229.1 Clone IMAGE:1575191 kidney 3' read A
AA975356.1 Clone IMAGE:1588683 kidney 3' read A
AA902787.1 Clone IMAGE:1519505 uncharacterized tissue 3' read
AI002978.1 Clone IMAGE:1699545 kidney 3' read
AI014735.1 Clone IMAGE:1598750 uncharacterized tissue 3' read A
AI027715.1 Clone IMAGE:1644541 testis 3' read PA
AI028256.1 Clone IMAGE:1645546 testis 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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