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Phosphatase and tensin homolog (PTEN)
Human protein-coding gene PTEN. Represented by 396 ESTs from 178 cDNA libraries. Corresponds to reference sequence NM_000314.4. [UniGene 715625 - Hs.500466]
SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
| Best Hits and Hits from model organisms | Species | Id(%) | Len(aa) |
|
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Pten gene product |
M. musculus |
100.0 |
402 |
|
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Pten gene product |
R. norvegicus |
100.0 |
402 |
|
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PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 2 |
M. mulatta |
100.0 |
402 |
|
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PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
P. anubis |
100.0 |
402 |
|
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PREDICTED: hypothetical protein LOC466142 |
P. troglodytes |
100.0 |
402 |
|
|
PTEN gene product |
H. sapiens |
100.0 |
402 |
|
|
PTEN gene product |
C. lupus familiaris |
100.0 |
402 |
|
|
PTEN gene product |
S. scrofa |
100.0 |
402 |
|
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PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
B. taurus |
100.0 |
402 |
|
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PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
O. aries |
100.0 |
402 |
|
|
PREDICTED: phosphatase and tensin homolog |
O. cuniculus |
100.0 |
402 |
|
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PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like |
E. caballus |
99.5 |
402 |
|
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uncharacterized protein LOC100505440 |
X. laevis |
92.8 |
401 |
|
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ptenb gene product |
D. rerio |
92.5 |
398 |
|
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pten, isoform C |
D. melanogaster |
59.0 |
283 |
|
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Calcium/lipid-binding (CaLB) phosphatase |
A. thaliana |
50.6 |
176 |
|
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Protein DAF-18 |
C. elegans |
47.3 |
148 |
| Other hits (2 of 37) [Show all] | Species | Id(%) | Len(aa) |
|
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PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
G. gallus |
98.3 |
402 |
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PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like |
M. gallopavo |
97.9 |
377 |
GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
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EST Profile: | Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this] |
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GEO Profiles: |
Experimental gene expression data (Gene Expression Omnibus). |
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cDNA Sources: |
lymph node; mixed; brain; placenta; connective tissue; lung; intestine; pancreas; prostate; muscle; cervix; uncharacterized tissue; stomach; testis; kidney; thymus; uterus; spleen; eye; larynx; ear; vascular; skin; blood; liver; parathyroid; bladder; heart; embryonic tissue; thyroid; pituitary gland; adipose tissue; ovary; lymph; bone; mammary gland; umbilical cord; tonsil; adrenal gland |
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.
mRNA sequences (9)
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NM_000314.4 |
Homo sapiens phosphatase and tensin homolog (PTEN), mRNA |
PA |
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CR450306.1 |
Homo sapiens full open reading frame cDNA clone RZPDo834E031D for gene PTEN, phosphatase and tensin homolog (mutated in multiple advanced cancers 1); complete cds; without stopcodon |
P |
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AK024986.1 |
Homo sapiens cDNA: FLJ21333 fis, clone COL02535 |
A |
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BC005821.2 |
Homo sapiens phosphatase and tensin homolog, mRNA (cDNA clone MGC:11227 IMAGE:3937787), complete cds |
PA |
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AK313581.1 |
Homo sapiens cDNA, FLJ94145, Homo sapiens phosphatase and tensin homolog (mutated in multipleadvanced cancers 1) (PTEN), mRNA |
P |
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JF268690.1 |
Homo sapiens PTEN splice variant (PTEN) mRNA, complete cds, alternatively spliced |
P |
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U92436.1 |
Human mutated in multiple advanced cancers protein (MMAC1) mRNA, complete cds |
PA |
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U96180.1 |
Human protein tyrosine phosphatase (TEP1) mRNA, complete cds |
PA |
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U93051.1 |
Human putative protein tyrosine phosphatase (PTEN) mRNA, complete cds |
P |
EST sequences (10 of 396) [Show all sequences]
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AA954495.1 |
Clone IMAGE:1563063 |
mixed |
3' read |
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AA977984.1 |
Clone IMAGE:1590220 |
kidney |
3' read |
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AI016285.1 |
Clone IMAGE:1622293 |
embryonic tissue |
3' read |
A |
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AI089058.1 |
Clone IMAGE:1634656 |
mixed |
3' read |
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AI090152.1 |
Clone IMAGE:1698079 |
uterus |
3' read |
A |
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AI125980.1 |
Clone IMAGE:1712660 |
uterus |
3' read |
A |
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AI214472.1 |
Clone IMAGE:1840413 |
mixed |
3' read |
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AI222037.1 |
Clone IMAGE:1843443 |
mixed |
3' read |
P |
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AI223055.1 |
Clone IMAGE:1840501 |
mixed |
3' read |
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AI223800.1 |
Clone IMAGE:1858261 |
mixed |
3' read |
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Key to Symbols
P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria
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