Neurotrophic tyrosine kinase, receptor, type 2 (NTRK2)

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UGID:709471 UniGene Hs.494312 Homo sapiens (human) NTRK2

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Neurotrophic tyrosine kinase, receptor, type 2 (NTRK2)

Human protein-coding gene NTRK2. Represented by 706 ESTs from 181 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 709471 - Hs.494312]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001248226.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	BDNF/NT-3 growth factors receptor precursor	M. mulatta	100.0	837
XP_003911919.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: BDNF/NT-3 growth factors receptor isoform 2	P. anubis	100.0	837
XP_001135326.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: BDNF/NT-3 growth factors receptor isoform 4	P. troglodytes	100.0	837
NP_006171.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	NTRK2 gene product	H. sapiens	100.0	837
NP_001020245.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Ntrk2 gene product	M. musculus	96.6	820
NP_001079579.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	neurotrophic tyrosine kinase, receptor, type 2	X. laevis	81.8	820
XP_003199193.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: BDNF/NT-3 growth factors receptor	D. rerio	74.7	771
NP_476962.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Ror	D. melanogaster	49.6	270
Other hits (2 of 35) [Show all]		Species	Id(%)	Len(aa)
XP_848589.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: BDNF/NT-3 growth factors receptor isoform 2	C. lupus familiaris	99.0	837
XP_003364034.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: BDNF/NT-3 growth factors receptor	E. caballus	98.8	837

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; mouth; testis; esophagus; kidney; thyroid; ovary; eye; spleen; mixed; uncharacterized tissue; heart; adrenal gland; mammary gland; liver; connective tissue; intestine; trachea; lung; pituitary gland; stomach; ear; pancreas; thymus; larynx; muscle; bone; embryonic tissue; uterus; prostate; adipose tissue; bladder; pineal gland; nerve

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	9
Map position:	9q22.1
UniSTS entry:	Chr 9	G43552
UniSTS entry:	Chr 9	RH93005
UniSTS entry:	Chr 9	RH46089
UniSTS entry:	Chr 9	A004Y44	[Map Viewer]
UniSTS entry:	Chr 9	A005L08
UniSTS entry:	Chr 9	G20302
UniSTS entry:		Ntrk2
UniSTS entry:		Ntrk2
UniSTS entry:	Chr 9	D9S1063E
UniSTS entry:	Chr 9	WIAF-2133	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (28)

BX649001.1	Homo sapiens mRNA; cDNA DKFZp686D1394 (from clone DKFZp686D1394)	A
AK123824.1	Homo sapiens cDNA FLJ41830 fis, clone NT2RI2027081
NM_006180.3	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a, mRNA	P
BC075804.1	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2, mRNA (cDNA clone IMAGE:4939307), with apparent retained intron	PA
NM_001007097.1	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA	P
AB209118.1	Homo sapiens mRNA for BDNF/NT-3 growth factors receptor precursor variant protein	P
NM_001018066.2	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant e, mRNA	PA
NM_001018065.2	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant d, mRNA	PA
NM_001018064.1	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant c, mRNA	P
AF400441.1	Homo sapiens neurotrophic tyrosine kinase receptor type 2 (NTRK2) mRNA, complete cds	P
AJ420458.1	Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1630957	A
AF410901.1	Homo sapiens neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, complete cds; alternatively spliced	PA
AF410900.1	Homo sapiens neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, complete cds; alternatively spliced	PA
AF410899.1	Homo sapiens neurotrophin receptor tyrosine kinase type 2 (NTRK2) mRNA, complete cds; alternatively spliced	P
AF410898.1	Homo sapiens clone DKFZp547L014 neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, partial cds; alternatively spliced	PA
AK289904.1	Homo sapiens cDNA FLJ76753 complete cds, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA	P
AL713745.1	Homo sapiens mRNA; cDNA DKFZp761J0523 (from clone DKFZp761J0523)	A
BC031309.2	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2, mRNA (cDNA clone IMAGE:5274382)	A
BC031835.1	Homo sapiens neurotrophic tyrosine kinase, receptor, type 2, mRNA (cDNA clone MGC:24881 IMAGE:4941763), complete cds	PA
AF508964.1	Homo sapiens protein tyrosine kinase non catalytic form (NTRK2) mRNA, complete cds	PA
AK092267.1	Homo sapiens cDNA FLJ34948 fis, clone NT2RP7009108
AL833196.1	Homo sapiens mRNA; cDNA DKFZp667A176 (from clone DKFZp667A176)	A
AK294285.1	Homo sapiens cDNA FLJ53976 complete cds, highly similar to BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)	P
AF086101.1	Homo sapiens full length insert cDNA clone YZ91G09	A
S76473.1	trkB [human, brain, mRNA, 3194 nt]	PA
S76474.1	trkB {alternatively spliced} [human, brain, mRNA, 1870 nt]	P
X75958.1	H.sapiens trkB mRNA for protein-tyrosine kinase	P
U12140.1	Human tyrosine kinase receptor p145TRK-B (TRK-B) mRNA, complete cds	P

EST sequences (10 of 706) [Show all sequences]

R14685.1	Clone IMAGE:30166	brain	5' read
AA985292.1	Clone IMAGE:1616216	brain	3' read
AA987440.1	Clone IMAGE:1593909	kidney	3' read
R17182.1	Clone IMAGE:31920	brain	5' read
R17831.1	Clone IMAGE:31771	brain	5' read
AI018523.1	Clone IMAGE:1630957	mammary gland	3' read	A
R18491.1	Clone IMAGE:30260	brain	5' read
AI049873.1	Clone IMAGE:1699357	kidney	3' read	A
AI081305.1	Clone IMAGE:1661894	mixed	3' read
AI092806.1	Clone IMAGE:1693109	heart	3' read	PA

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria