> Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR)
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UGID:704945     UniGene Hs.489786     Homo sapiens (human)   CFTR Links
Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR)

Human protein-coding gene CFTR. Represented by 117 ESTs from 52 cDNA libraries. EST representation biased toward colorectal tumor; adult. Corresponds to reference sequence NM_000492.3. [UniGene 704945 - Hs.489786]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000483.3 CFTR gene product H. sapiens 100.0 1479
NP_001073386.1 CFTR gene product P. troglodytes 99.9 1479
NP_066388.1 Cftr gene product M. musculus 81.6 1475
NP_001038348.1 cftr gene product D. rerio 59.9 1484
NP_188762.3 multidrug resistance-associated protein 6 A. thaliana 47.6 166
NP_611571.2 CG10505 D. melanogaster 45.8 166
NP_499598.2 Protein MRP-8 C. elegans 45.2 186
Other hits (2 of 42) [Show all]SpeciesId(%)Len(aa)
NP_001106085.1 CFTR gene product P. anubis 98.8 1480
NP_001028110.1 CFTR gene product M. mulatta 98.8 1480

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: colorectal tumor [show more like this]
adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: intestine; pancreas; liver; uterus; stomach; uncharacterized tissue; salivary gland; kidney; muscle; bladder; mixed; ovary; lung; trachea; brain; thyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 7
Map position: 7q31.2
UniSTS entry: Chr 7 STS-M28668 [Map Viewer]
UniSTS entry: Chr 7 REN62722
UniSTS entry: Chr 7 REN62726
UniSTS entry: Chr 7 REN62723
UniSTS entry: Chr 7 ECD07747
UniSTS entry: Chr 7 CFTR
UniSTS entry: G49398
UniSTS entry: Chr 7 GDB:204205
UniSTS entry: Chr 7 ECD11938
UniSTS entry: Chr 7 REN62727
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (4)

NM_000492.3 Homo sapiens cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR), mRNA P
DQ656054.2 Homo sapiens clone UGLsupplH, mRNA sequence
BC143713.1 Homo sapiens cDNA clone IMAGE:9052227, containing frame-shift errors P
M28668.1 Human cystic fibrosis mRNA, encoding a presumed transmembrane conductance regulator (CFTR) P

EST sequences (10 of 117) [Show all sequences]

BX098596.1 Clone IMAGp998F065597_;_IMAGE:2260997 ovary A
BX111341.1 Clone IMAGp998I216073_;_IMAGE:2442716 uterus A
CB158836.1 Clone L18POOL1n1-27-B07 liver 5' read
CB141880.1 Clone L11SNU354s1-2-C04 liver 5' read
AI283201.1 Clone IMAGE:1872366 intestine 3' read A
AI289618.1 Clone IMAGE:1992465 uterus 3' read
AI357827.1 Clone IMAGE:1980167 stomach 3' read A
AI380125.1 Clone IMAGE:2107310 uncharacterized tissue 3' read A
AI475146.1 Clone IMAGE:2153271 intestine 3' read A
AI609591.1 Clone IMAGE:2260997 ovary 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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