> Kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)
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UGID:694915     UniGene Hs.479756     Homo sapiens (human)   KDR Order cDNA clone, Links
Kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)

Human protein-coding gene KDR. Represented by 189 ESTs from 105 cDNA libraries. Corresponds to reference sequence NM_002253.2. [UniGene 694915 - Hs.479756]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_517284.3 PREDICTED: vascular endothelial growth factor receptor 2 P. troglodytes 100.0 1355
NP_002244.1 KDR gene product H. sapiens 100.0 1355
XP_003898930.1 PREDICTED: vascular endothelial growth factor receptor 2-like, partial P. anubis 99.7 324
NP_034742.2 Kdr gene product M. musculus 90.5 1344
NP_001019824.2 kdr gene product D. rerio 61.2 1300
NP_001081338.1 fibroblast growth factor receptor precursor X. laevis 51.9 283
NP_524934.2 Src oncogene at 64B, isoform B D. melanogaster 48.8 160
NP_509779.2 Protein ABL-1, isoform c C. elegans 46.1 165
Other hits (2 of 38) [Show all]SpeciesId(%)Len(aa)
XP_001086814.2 PREDICTED: vascular endothelial growth factor receptor 2 M. mulatta 99.1 1360
XP_003129035.3 PREDICTED: vascular endothelial growth factor receptor 2 S. scrofa 95.8 1355

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; eye; placenta; embryonic tissue; liver; prostate; mouth; adrenal gland; lung; kidney; stomach; uterus; intestine; spinal cord; ear; pancreas; mammary gland; uncharacterized tissue; testis; vascular; parathyroid; heart; pituitary gland; thyroid; bone; connective tissue; trachea; muscle; adipose tissue; ganglia; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4q11-q12
UniSTS entry: Chr 4 A005U41 [Map Viewer]
UniSTS entry: Chr 4 G20520
UniSTS entry: Chr 4 GDB:626093
UniSTS entry: Chr 4 SHGC-59525 [Map Viewer]
UniSTS entry: Chr 4 GDB:626090
UniSTS entry: Chr 4 SHGC-59221 [Map Viewer]
UniSTS entry: Chr 4 RH70435 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AF063658.1 Homo sapiens vascular endothelial growth factor receptor 2 (KDR) mRNA, complete cds P
AB209901.1 Homo sapiens mRNA for kinase insert domain receptor (a type III receptor tyrosine kinase) variant protein P
L04947.1 Homo sapiens (clones BT3.081.8, BT3.129.5 and BT4.169) receptor tyrosine kinase (KDR) mRNA, 3' end cds P
NM_002253.2 Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), mRNA PA
BC131822.1 Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase), mRNA (cDNA clone MGC:157715 IMAGE:40129287), complete cds P
AK293668.1 Homo sapiens cDNA FLJ56959 complete cds, highly similar to Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) P
EU826563.1 Homo sapiens soluble VEGFR2 (VEGFR2) mRNA, complete cds, alternatively spliced P
X61656.1 H.sapiens mRNA for growth factor receptor tyrosine kinase P
FJ899739.1 Homo sapiens truncated soluble vascular endothelial growth factor receptor 2 mRNA, complete cds, alternatively spliced P
AF035121.1 Homo sapiens KDR/flk-1 protein mRNA, complete cds P

EST sequences (10 of 189) [Show all sequences]

AA993647.1 Clone IMAGE:1623517 embryonic tissue 3' read A
R17598.1 Clone IMAGE:32344 brain 5' read
AA947320.1 Clone IMAGE:1589431 kidney 3' read A
BX114752.1 Clone IMAGp998G02531_;_IMAGE:246169 mixed
AI241917.1 Clone IMAGE:1977656 brain 3' read A
AI280258.1 Clone IMAGE:1893862 placenta 3' read A
R35713.1 Clone IMAGE:38119 brain 5' read
R38646.1 Clone IMAGE:23003 brain 3' read A
AI347902.1 Clone IMAGE:1916991 kidney 3' read A
AI378283.1 Clone IMAGE:2067422 embryonic tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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