> Thyroid peroxidase (TPO)
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UGID:682713     UniGene Hs.467554     Homo sapiens (human)   TPO Order cDNA clone, Links
Thyroid peroxidase (TPO)

Human protein-coding gene TPO. Represented by 74 ESTs from 31 cDNA libraries. EST representation biased toward thyroid. Corresponds to 6 reference sequences (different isoforms). [UniGene 682713 - Hs.467554]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000538.3 TPO gene product H. sapiens 100.0 932
NP_033443.1 Tpo gene product M. musculus 78.6 905
XP_003200347.1 PREDICTED: thyroid peroxidase-like D. rerio 63.8 307
NP_523891.2 peroxidasin, isoform A D. melanogaster 49.1 232
NP_001081848.1 eosinophil peroxidase precursor X. laevis 47.0 287
NP_505188.3 Protein PXN-1 C. elegans 46.6 234
Other hits (2 of 37) [Show all]SpeciesId(%)Len(aa)
XP_003308907.1 PREDICTED: thyroid peroxidase, partial P. troglodytes 99.1 1043
XP_003908272.1 PREDICTED: thyroid peroxidase isoform 1 P. anubis 97.5 872

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: thyroid [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: thyroid; uncharacterized tissue; mixed; larynx; intestine; heart; testis; connective tissue; brain; spleen; muscle; adipose tissue; blood
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2p25
UniSTS entry: Chr 2 D8S2035 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (21)

NM_175722.3 Homo sapiens thyroid peroxidase (TPO), transcript variant 5, mRNA P
NM_175721.3 Homo sapiens thyroid peroxidase (TPO), transcript variant 4, mRNA P
NM_175719.3 Homo sapiens thyroid peroxidase (TPO), transcript variant 2, mRNA P
NM_000547.5 Homo sapiens thyroid peroxidase (TPO), transcript variant 1, mRNA P
BC063107.1 Homo sapiens thyroid peroxidase, mRNA (cDNA clone IMAGE:30325379), complete cds PA
M17755.2 Homo sapiens thyroid peroxidase (TPO) mRNA, complete cds P
BC095448.1 Homo sapiens thyroid peroxidase, mRNA (cDNA clone MGC:111197 IMAGE:30329791), complete cds PA
J02969.1 Human thyroid peroxidase mRNA, clone phTPO-2.8 P
J02970.1 Human thyroid peroxidase mRNA, clone phTPO-2.4 P
M55702.1 Human thyroperoxidase mRNA, 3' end, and the Graves' disease mutation P
Y00406.1 Human mRNA for thyroperoxidase P
AF439430.1 Homo sapiens thyroid peroxidase mRNA, complete cds; alternatively spliced P
AK309868.1 Homo sapiens cDNA, FLJ99909 P
X17358.1 Human mRNA from alternatively spliced TPO-2 gene for thyroid peroxidase (EC.1.11.1.7) P
AF533531.1 Homo sapiens thyroid peroxidase isoform 2/4 (TPO) mRNA, partial cds; alternatively spliced P
AF533530.1 Homo sapiens thyroid peroxidase isoform 2/3 (TPO) mRNA, partial cds; alternatively spliced P
AF533529.1 Homo sapiens thyroid peroxidase isoform 6 (TPO) mRNA, partial cds; alternatively spliced P
AF533528.1 Homo sapiens thyroid peroxidase isoform 5 (TPO) mRNA, partial cds; alternatively spliced P
AY136822.1 Homo sapiens thyroid peroxidase isoform 4 (TPO) mRNA, partial cds; alternatively spliced P
NM_001206745.1 Homo sapiens thyroid peroxidase (TPO), transcript variant 7, mRNA PA
NM_001206744.1 Homo sapiens thyroid peroxidase (TPO), transcript variant 6, mRNA PA

EST sequences (10 of 74) [Show all sequences]

CB986756.1 Clone IMAGE:30329437 mixed 5' read P
CB987194.1 Clone IMAGE:30329791 mixed 5' read P
CB987523.1 Clone IMAGE:30325379 mixed 5' read P
AW137846.1 Clone IMAGE:2716915 mixed 3' read A
AJ573347.1 Clone HSPD46629 muscle
CD608883.1 uncharacterized tissue P
CD608884.1 uncharacterized tissue P
CD608885.1 uncharacterized tissue P
CD608886.1 uncharacterized tissue P
CD608887.1 uncharacterized tissue P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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