> Rho/Rac guanine nucleotide exchange factor (GEF) 18 (ARHGEF18)
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UGID:680920     UniGene Hs.465761     Homo sapiens (human)   ARHGEF18 Order cDNA clone, Links
Rho/Rac guanine nucleotide exchange factor (GEF) 18 (ARHGEF18)

Human protein-coding gene ARHGEF18. Represented by 271 ESTs from 132 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 680920 - Hs.465761]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001124427.1 ARHGEF18 gene product H. sapiens 100.0 1172
NP_598723.3 rho guanine nucleotide exchange factor 18 M. musculus 86.0 1020
XP_690750.5 PREDICTED: rho guanine nucleotide exchange factor 18 D. rerio 61.3 1023
NP_001129636.1 Rho/Rac guanine nucleotide exchange factor (GEF) 2 X. laevis 53.3 422
Other hits (2 of 23) [Show all]SpeciesId(%)Len(aa)
XP_001145436.1 PREDICTED: rho guanine nucleotide exchange factor 18, partial P. troglodytes 99.5 781
XP_001095927.2 PREDICTED: rho guanine nucleotide exchange factor 18-like M. mulatta 97.4 1126

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; spleen; kidney; prostate; mixed; liver; blood; lymph; lymph node; thymus; ovary; eye; uterus; intestine; testis; embryonic tissue; placenta; stomach; skin; lung; pancreas; mammary gland; trachea; vascular; heart; thyroid; ascites; nerve; bladder; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.3
UniSTS entry: Chr 19 WI-14772 [Map Viewer]
UniSTS entry: Chr 19 RH78224
UniSTS entry: Chr 19 ARHGEF18_8009
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

AK127453.1 Homo sapiens cDNA FLJ45545 fis, clone BRTHA2034281
AK127045.1 Homo sapiens cDNA FLJ45102 fis, clone BRAWH3032340, highly similar to Homo sapiens Rho-specific guanine nucleotide exchange factor p114 (P114-RHO-GEF) P
BC077721.1 Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 18, mRNA (cDNA clone MGC:78478 IMAGE:5921159), complete cds PA
BC008016.1 Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 18, mRNA (cDNA clone IMAGE:3534293) A
NM_015318.3 Homo sapiens Rho/Rac guanine nucleotide exchange factor (GEF) 18 (ARHGEF18), transcript variant 1, mRNA PA
BC014994.1 Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 18, mRNA (cDNA clone IMAGE:4849158) A
AK074372.1 Homo sapiens cDNA FLJ23792 fis, clone HEP21723 PA
NM_001130955.1 Homo sapiens Rho/Rac guanine nucleotide exchange factor (GEF) 18 (ARHGEF18), transcript variant 2, mRNA PA
AB011093.1 Homo sapiens mRNA for KIAA0521 protein, partial cds P

EST sequences (10 of 271) [Show all sequences]

AI097369.1 Clone IMAGE:1698682 uterus 3' read A
AA947585.1 Clone IMAGE:1508456 mixed 3' read
AI084572.1 Clone IMAGE:1661002 mixed 3' read
AI168224.1 Clone IMAGE:1509316 mixed 3' read A
AI335866.1 Clone IMAGE:1948653 uncharacterized tissue 3' read A
AI632373.1 Clone IMAGE:2181981 uterus 3' read A
AI673556.1 Clone IMAGE:2346938 intestine 3' read A
AI673684.1 Clone IMAGE:2347128 intestine 3' read A
AI688285.1 Clone IMAGE:2325656 intestine 3' read A
AI697672.1 Clone IMAGE:2341219 lung 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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