> Aldo-keto reductase family 1, member C1 (AKR1C1)
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UGID:675419     UniGene Hs.460260     Homo sapiens (human)   AKR1C1 Order cDNA clone, Links
Aldo-keto reductase family 1, member C1 (AKR1C1)

Human protein-coding gene AKR1C1. Represented by 883 ESTs from 169 cDNA libraries. Corresponds to reference sequence NM_001353.5. [UniGene 675419 - Hs.460260]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001345.1 AKR1C2 gene product H. sapiens 100.0 322
NP_085114.1 Akr1c6 gene product M. musculus 82.0 322
NP_001079568.1 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) X. laevis 73.0 321
NP_001070715.1 si:dkey-180p18.9 gene product D. rerio 56.5 314
NP_648484.1 CG6084, isoform A D. melanogaster 54.6 312
NP_001031505.1 NAD(P)-linked oxidoreductase-like protein A. thaliana 48.9 266
NP_496924.1 Protein Y39G8B.1, isoform b C. elegans 45.9 183
NP_011972.1 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) S. cerevisiae 45.2 188
Other hits (2 of 52) [Show all]SpeciesId(%)Len(aa)
XP_003951630.1 PREDICTED: aldo-keto reductase family 1 member C1 homolog P. troglodytes 98.7 309
XP_003903384.1 PREDICTED: aldo-keto reductase family 1 member C1 homolog isoform 1 P. anubis 96.3 322

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; mouth; lung; brain; mixed; trachea; ascites; testis; thymus; thyroid; ovary; blood; esophagus; adrenal gland; heart; muscle; skin; bladder; larynx; stomach; mammary gland; intestine; pharynx; vascular; salivary gland; eye; connective tissue; uncharacterized tissue; pancreas; spinal cord; kidney; adipose tissue; nerve; uterus; embryonic tissue; pituitary gland; cervix; bone
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10p15-p14
UniSTS entry: Chr 10 RH11162
UniSTS entry: SHGC-12403
UniSTS entry: Chr 10 STS-R98791
UniSTS entry: Chr 10 SHGC-100143
UniSTS entry: Chr 10 STS-U05861
UniSTS entry: Chr 10 RH92273
UniSTS entry: Chr 10 RH1568 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

AB021654.1 Homo sapiens mRNA for DD2/bile acid-binding protein/AKR1C2/3alpha-hydroxysteroid dehydrogenase type 3, complete cds P
BT007197.1 Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) mRNA, complete cds P
BT006653.1 Homo sapiens aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) mRNA, complete cds P
NM_001353.5 Homo sapiens aldo-keto reductase family 1, member C1 (AKR1C1), mRNA P
AB031083.1 Homo sapiens mRNA for 20 alpha-hydroxysteroid dehydrogenase, complete cds P
AB031084.1 Homo sapiens mRNA for bile acid-binding protein, complete cds P
U05684.1 Homo sapiens dihydrodiol dehydrogenase mRNA, complete cds PA
AK226067.1 Homo sapiens mRNA for aldo-keto reductase family 1, member C1 variant, clone: fk04082 A
M86609.1 Homo sapiens dihydrodiol dehydrogenase mRNA, complete cds P
BC015490.2 Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), mRNA (cDNA clone MGC:8954 IMAGE:3877178), complete cds PA
BC020216.1 Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), mRNA (cDNA clone MGC:31890 IMAGE:4662654), complete cds PA
AK310658.1 Homo sapiens cDNA, FLJ17700 P
AK303435.1 Homo sapiens cDNA FLJ60052 complete cds, highly similar to Aldo-keto reductase family 1 member C1 (EC1.1.1.-) P
S68290.1 chlordecone reductase homolog {clone HAKRc} [human, liver, mRNA, 1158 nt] P
D26124.1 Homo sapiens mRNA for dihydrodiol dehydrogenase isoform DD1, partial cds P
BC040210.1 Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), mRNA (cDNA clone MGC:42600 IMAGE:4825338), complete cds PA

EST sequences (10 of 883) [Show all sequences]

AA962456.1 Clone IMAGE:1553575 kidney 3' read A
BX106706.1 Clone IMAGp998D20664_;_IMAGE:297187 mixed
AI203621.1 Clone IMAGE:1744844 lung 3' read PA
CB157186.1 Clone L17N670205n1-7-D05 liver 5' read P
CB163887.1 Clone L17N670205n1-52-A03 liver 5' read P
CB158546.1 Clone L18POOL1n1-11-E07 liver 5' read P
CB159474.1 Clone L18POOL1n1-39-B03 liver 5' read P
CB158428.1 Clone L19N779227-1-A09 liver 5' read P
CB106385.1 Clone L3SNU475-3-E12 liver 5' read P
CB106407.1 Clone L3SNU475-3-H05 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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