> V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
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UGID:241389     UniGene Hs.446352     Homo sapiens (human)   ERBB2 Order cDNA clone, Links
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)

Human protein-coding gene ERBB2. Represented by 514 ESTs from 236 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 241389 - Hs.446352]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004439.2 ERBB2 gene product H. sapiens 100.0 1254
XP_003315512.2 PREDICTED: LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 isoform 1 P. troglodytes 99.9 1254
XP_003912981.1 PREDICTED: receptor tyrosine-protein kinase erbB-2 P. anubis 99.6 1254
NP_001003817.1 Erbb2 gene product M. musculus 92.4 1255
NP_001089062.1 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog precursor X. laevis 73.2 1278
NP_956413.2 erbb2 gene product D. rerio 68.6 1254
NP_476758.1 epidermal growth factor receptor, isoform A D. melanogaster 60.4 422
NP_495962.2 Protein LET-23, isoform a C. elegans 46.6 264
Other hits (2 of 36) [Show all]SpeciesId(%)Len(aa)
XP_001090430.1 PREDICTED: receptor tyrosine-protein kinase erbB-2 isoform 2 M. mulatta 99.4 1254
XP_001501155.1 PREDICTED: receptor tyrosine-protein kinase erbB-2 E. caballus 96.4 1254

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: intestine; mammary gland; embryonic tissue; placenta; brain; liver; skin; thymus; ascites; connective tissue; heart; bone; ganglia; mixed; larynx; bladder; eye; blood; testis; lung; bone marrow; nerve; muscle; uncharacterized tissue; thyroid; mouth; ovary; prostate; amniotic fluid; uterus; stomach; kidney; spleen; pancreas; trachea; salivary gland; cervix; lymph node; pharynx; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q12
UniSTS entry: Chr 17 RH75810
UniSTS entry: Chr 17 GDB:285022
UniSTS entry: GDB:181407
UniSTS entry: Chr 1 D11S2921
UniSTS entry: Chr 1 D1S3688
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

M11730.1 Human tyrosine kinase-type receptor (HER2) mRNA, complete cds P
NM_004448.2 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA P
BC080193.1 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), mRNA (cDNA clone IMAGE:6178526) PA
NM_001005862.1 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 2, mRNA P
AF177761.2 Homo sapiens herstatin (HER-2) mRNA, alternatively spliced, complete cds P
BC110392.1 Homo sapiens cDNA clone IMAGE:5195657 PA
X03363.1 Human c-erb-B-2 mRNA P
AK309029.1 Homo sapiens cDNA, FLJ99070
AK313683.1 Homo sapiens cDNA, FLJ94272 P
BC167147.1 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), mRNA (cDNA clone MGC:166940 IMAGE:100013444), complete cds P
AK300321.1 Homo sapiens cDNA FLJ59426 complete cds, highly similar to Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) P
AK296908.1 Homo sapiens cDNA FLJ55711 complete cds, highly similar to Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) PA
AB025286.1 Homo sapiens c-ERBB-2 mRNA, 5' UTR
S57296.1 HER2/neu receptor {3' region, alternatively spliced} [human, breast cancer cell line, mRNA Partial, 175 nt]
HM437238.1 Homo sapiens receptor tyrosine-protein kinase erbB-2 variant (ERBB2) mRNA, partial cds P

EST sequences (10 of 514) [Show all sequences]

AA985406.1 Clone IMAGE:1592821 kidney 3' read A
AA995651.1 Clone IMAGE:1604225 lung 3' read
AI076724.1 Clone IMAGE:1676384 embryonic tissue 3' read
AI127589.1 Clone IMAGE:1710703 uterus 3' read
AI149552.1 Clone IMAGE:1715003 placenta 3' read A
BX113765.1 Clone IMAGp998E101931_;_IMAGE:783729 embryonic tissue P
AI192793.1 Clone IMAGE:1744079 lung 3' read A
AI193477.1 Clone IMAGE:1743271 lung 3' read
CB129403.1 Clone C1SNU17-5-C08 cervix 5' read P
AI276373.1 Clone IMAGE:1990573 uterus 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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