> Growth factor receptor-bound protein 2 (GRB2)
NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs
UGID:239393     UniGene Hs.444356     Homo sapiens (human)   GRB2 Order cDNA clone, Links
Growth factor receptor-bound protein 2 (GRB2)

Human protein-coding gene GRB2. Represented by 1086 ESTs from 403 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 239393 - Hs.444356]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_032189.1 Grb2 gene product M. musculus 100.0 216
NP_110473.2 Grb2 gene product R. norvegicus 100.0 216
XP_003913476.1 PREDICTED: growth factor receptor-bound protein 2 isoform 1 P. anubis 100.0 216
NP_001233546.1 GRB2 gene product P. troglodytes 100.0 216
NP_002077.1 GRB2 gene product H. sapiens 100.0 216
XP_540431.2 PREDICTED: growth factor receptor-bound protein 2 isoform 1 C. lupus familiaris 100.0 216
XP_001495816.1 PREDICTED: growth factor receptor-bound protein 2-like isoform 1 E. caballus 100.0 216
NP_001131100.1 GRB2 gene product S. scrofa 100.0 216
XP_003583693.1 PREDICTED: growth factor receptor-bound protein 2 isoform 1 B. taurus 100.0 216
XP_002722985.1 PREDICTED: growth factor receptor-bound protein 2 isoform 1 O. cuniculus 100.0 216
XP_001095326.1 PREDICTED: growth factor receptor-bound protein 2-like M. mulatta 100.0 175
XP_001369479.1 PREDICTED: growth factor receptor-bound protein 2-like isoform 1 M. domestica 99.5 216
NP_001084357.1 growth factor receptor-bound protein 2-A X. laevis 97.2 216
NP_998200.1 grb2b gene product D. rerio 95.8 216
NP_476858.1 downstream of receptor kinase, isoform A D. melanogaster 70.2 208
NP_509342.1 Protein SEM-5 C. elegans 62.7 220
Other hits (2 of 29) [Show all]SpeciesId(%)Len(aa)
XP_003211652.1 PREDICTED: growth factor receptor-bound protein 2-like M. gallopavo 99.1 216
XP_003217257.1 PREDICTED: growth factor receptor-bound protein 2-like isoform 1 A. carolinensis 98.6 216

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; lung; uncharacterized tissue; placenta; embryonic tissue; mixed; testis; connective tissue; blood; muscle; skin; stomach; liver; pancreas; mammary gland; bladder; uterus; lymph node; eye; kidney; intestine; thymus; prostate; spleen; heart; ovary; mouth; adrenal gland; pituitary gland; umbilical cord; esophagus; trachea; larynx; tonsil; parathyroid; ascites; bone; vascular; ear; lymph; adipose tissue; nerve; cervix; salivary gland; thyroid; bone marrow
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q24-q25
UniSTS entry: Chr 17 D17S820E [Map Viewer]
UniSTS entry: Chr 17 RH17761
UniSTS entry: Chr 17 D17S820E
UniSTS entry: Chr 17 RH16251 [Map Viewer]
UniSTS entry: Chr 1 D11S3114
UniSTS entry: RH92685
UniSTS entry: GRB2
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (20)

BC043007.1 Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:5417009) A
AF171699.1 Homo sapiens MSTP084 (MST084) mRNA, complete cds A
NM_002086.4 Homo sapiens growth factor receptor-bound protein 2 (GRB2), transcript variant 1, mRNA PA
NM_203506.2 Homo sapiens growth factor receptor-bound protein 2 (GRB2), transcript variant 2, mRNA PA
CR450363.1 Homo sapiens full open reading frame cDNA clone RZPDo834D113D for gene GRB2, growth factor receptor-bound protein 2; complete cds; without stopcodon P
CR541942.1 Homo sapiens full open reading frame cDNA clone RZPDo834A0934D for gene GRB2, growth factor receptor-bound protein 2; complete cds, incl. stopcodon P
M96995.1 Homo sapiens epidermal growth factor receptor-binding protein GRB2 (EGFRBP-GRB2) mRNA sequence PA
AK024539.1 Homo sapiens cDNA: FLJ20886 fis, clone ADKA03257 A
AF302079.1 Homo sapiens HSP22-like protein interacting protein 17 mRNA, complete cds A
BC000631.2 Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone MGC:1737 IMAGE:3345524), complete cds PA
AF246238.1 Homo sapiens HT027 mRNA, complete cds A
BC127778.1 Homo sapiens cDNA clone IMAGE:40133065
AK315565.1 Homo sapiens cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA P
AF498925.1 Homo sapiens growth factor receptor-bound protein 2 (GRB2) mRNA, complete cds P
X62852.1 H.sapiens ash mRNA P
AK091010.1 Homo sapiens cDNA FLJ33691 fis, clone BRAWH2002976, highly similar to GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P
BC033644.1 Homo sapiens cDNA clone IMAGE:5563069 A
BC019082.2 Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:4649400) A
L29511.1 Human GRB2 isoform mRNA P
BC039827.1 Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:6044508), with apparent retained intron A

EST sequences (10 of 1086) [Show all sequences]

AA864493.1 Clone IMAGE:1460120 kidney 3' read
AA947952.1 Clone IMAGE:1416021 lung 3' read A
R16143.1 Clone IMAGE:53059 brain 3' read A
T05455.1 Clone HFBCY79 brain A
R15402.1 Clone IMAGE:53059 brain 5' read
AA975942.1 Clone IMAGE:1568015 lung 3' read A
R15115.1 Clone IMAGE:29519 brain 5' read
AA988203.1 Clone IMAGE:1603936 lung 3' read
AI002438.1 Clone IMAGE:1601997 lung 3' read A
AA927248.1 Clone IMAGE:1541304 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help