> CD74 molecule, major histocompatibility complex, class II invariant chain (CD74)
NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs
UGID:231605     UniGene Hs.436568     Homo sapiens (human)   CD74 Order cDNA clone, Links
CD74 molecule, major histocompatibility complex, class II invariant chain (CD74)

Human protein-coding gene CD74. Represented by 6425 ESTs from 508 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 231605 - Hs.436568]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001020330.1 CD74 gene product H. sapiens 100.0 295
NP_001138308.1 CD74 gene product P. troglodytes 100.0 231
NP_001036070.1 Cd74 gene product M. musculus 83.9 278
Other hits (2 of 14) [Show all]SpeciesId(%)Len(aa)
XP_003900416.1 PREDICTED: HLA class II histocompatibility antigen gamma chain isoform 2 P. anubis 97.6 293
XP_001099491.2 PREDICTED: HLA class II histocompatibility antigen gamma chain isoform 1 M. mulatta 94.5 326

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; tonsil; uncharacterized tissue; spleen; intestine; lymph; lung; lymph node; thymus; connective tissue; ovary; pancreas; heart; stomach; uterus; placenta; blood; liver; eye; mammary gland; adipose tissue; mixed; bone; muscle; adrenal gland; prostate; thyroid; kidney; testis; cervix; vascular; pharynx; bladder; ascites; skin; pituitary gland; salivary gland; esophagus; umbilical cord; trachea; ganglia; bone marrow; nerve; mouth; parathyroid; embryonic tissue; epididymis; ear; peritoneum; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5q32
UniSTS entry: Chr 5 RH46360 [Map Viewer]
UniSTS entry: Chr 5 RH93024
UniSTS entry: Chr 5 D5S2405
UniSTS entry: Chr 5 RH11625 [Map Viewer]
UniSTS entry: Chr 5 RH11594 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

K01144.1 Human major histocompatibility class II antigen gamma chain mRNA, complete cds P
BT019505.1 Homo sapiens CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) mRNA, complete cds P
NM_001025159.2 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 1, mRNA P
NM_001025158.2 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3, mRNA P
NM_004355.3 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 2, mRNA P
BC018726.1 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain, mRNA (cDNA clone MGC:31825 IMAGE:4853578), complete cds P
AK292076.1 Homo sapiens cDNA FLJ75773 complete cds, highly similar to Homo sapiens CD74 antigen (invariant polypeptide of majorhistocompatibility complex, class II antigen-associated) (CD74),mRNA P
BC024272.1 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain, mRNA (cDNA clone MGC:39144 IMAGE:4763768), complete cds P
AK297889.1 Homo sapiens cDNA FLJ56699 complete cds, highly similar to HLA class II histocompatibility antigen gamma chain P
X00497.1 Human mRNA for HLA-DR antigens associated invariant chain (p33) P
M28590.1 Human (clone pcDG-79) MHC HLA-DG protein 41 mRNA, partial cds P

EST sequences (10 of 6425) [Show all sequences]

AA866070.1 Clone IMAGE:1459443 kidney 3' read P
AA996253.1 Clone IMAGE:1605705 kidney 3' read
CB045600.1 Clone IMAGE:3218364 intestine 5' read P
BX090113.1 Clone IMAGp998M1678_;_IMAGE:66999 mixed P
AI214144.1 Clone IMAGE:1956888 brain 3' read
AI214156.1 Clone IMAGE:1956895 brain 3' read P
AI249970.1 Clone IMAGE:2004491 pancreas 3' read
R27890.1 Clone IMAGE:133787 placenta 5' read
CB157443.1 Clone L17N670205n1-9-F12 liver 5' read P
CB163669.1 Clone L17N670205n1-33-B11 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help