> Cyclin-dependent kinase 12 (CDK12)
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UGID:222951     UniGene Hs.416108     Homo sapiens (human)   CDK12 Order cDNA clone, Links
Cyclin-dependent kinase 12 (CDK12)

Human protein-coding gene CDK12. Represented by 243 ESTs from 123 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 222951 - Hs.416108]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_057591.2 CDK12 gene product H. sapiens 100.0 1489
XP_003315525.2 PREDICTED: cyclin-dependent kinase 12 P. troglodytes 99.7 1443
NP_001103096.1 Cdk12 gene product M. musculus 94.5 1483
XP_003200579.1 PREDICTED: hypothetical protein LOC100149834 D. rerio 66.7 1163
NP_001254915.1 Protein CDK-12, isoform c C. elegans 58.1 525
NP_201301.1 cyclin-dependent kinase C-2 A. thaliana 55.2 402
XP_001694199.1 cyclin dependent kinase C. reinhardtii 52.0 346
NP_001090029.1 cyclin-dependent kinase 9-A X. laevis 51.5 303
NP_477226.2 Cyclin-dependent kinase 9 D. melanogaster 49.9 329
NP_012783.1 Ctk1p S. cerevisiae 49.8 315
Other hits (2 of 63) [Show all]SpeciesId(%)Len(aa)
XP_001088594.1 PREDICTED: cell division protein kinase 12 isoform 2 M. mulatta 99.2 1489
XP_003912979.1 PREDICTED: cyclin-dependent kinase 12 isoform 2 P. anubis 99.2 1489

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; ovary; lung; brain; skin; prostate; lymph node; testis; mixed; embryonic tissue; mammary gland; pancreas; kidney; intestine; placenta; uterus; liver; eye; larynx; stomach; mouth; bone marrow; lymph; bone; thymus; bladder; cervix; ascites; nerve; connective tissue; heart
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q12
UniSTS entry: Chr 17 SHGC-58832
UniSTS entry: Chr 17 RH102939
UniSTS entry: Chr 17 RH70045 [Map Viewer]
UniSTS entry: Chr 17 RH92543
UniSTS entry: Chr 17 CRK7_9758
UniSTS entry: Chr 17 RH45437 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

AB020711.2 Homo sapiens mRNA for KIAA0904 protein, partial cds P
AF227198.1 Homo sapiens CrkRS mRNA, complete cds PA
NM_016507.2 Homo sapiens cyclin-dependent kinase 12 (CDK12), transcript variant 1, mRNA P
BC012428.1 Homo sapiens, clone IMAGE:3862468, mRNA A
BC150265.1 Homo sapiens Cdc2-related kinase, arginine/serine-rich, mRNA (cDNA clone MGC:166847 IMAGE:9007217), complete cds PA
NM_015083.1 Homo sapiens cyclin-dependent kinase 12 (CDK12), transcript variant 2, mRNA P
AK302645.1 Homo sapiens cDNA FLJ60980 complete cds, highly similar to Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) P
BC140854.1 Homo sapiens Cdc2-related kinase, arginine/serine-rich, mRNA (cDNA clone MGC:176531 IMAGE:9021722), complete cds P

EST sequences (10 of 243) [Show all sequences]

AI003928.1 Clone IMAGE:1621857 testis 3' read A
AI081228.1 Clone IMAGE:1662257 mixed 3' read A
AI123947.1 Clone IMAGE:1688981 mixed 3' read A
AI128124.1 Clone IMAGE:1711800 uterus 3' read P
AI138391.1 Clone IMAGE:1736140 testis 3' read P
CB049262.1 Clone IMAGE:3271434 prostate 3' read A
CB049263.1 Clone IMAGE:3271434 prostate 5' read
BX119213.1 Clone IMAGp998J066083_;_IMAGE:2446565 stomach A
AI264202.1 Clone IMAGE:1857091 mixed 3' read P
CB122671.1 Clone L10ChoCK0-23-B09 liver 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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