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UGID:216556     UniGene Hs.401537     Homo sapiens (human)   SPPL2A
Signal peptide peptidase like 2A (SPPL2A)

Human protein-coding gene SPPL2A. Represented by 232 ESTs from 124 cDNA libraries. Corresponds to reference sequence NM_032802.3. [UniGene 216556 - Hs.401537]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001169194.1 PREDICTED: signal peptide peptidase-like 2A-like isoform 4 P. troglodytes 100.0 519
NP_116191.2 SPPL2A gene product H. sapiens 100.0 519
NP_075709.2 Sppl2a gene product M. musculus 85.8 522
NP_001079884.1 signal peptide peptidase like 2B X. laevis 55.7 472
NP_001032516.1 zgc:123258 gene product D. rerio 55.6 514
Other hits (2 of 26) [Show all]SpeciesId(%)Len(aa)
XP_002804820.1 PREDICTED: signal peptide peptidase-like 2A-like M. mulatta 96.5 455
XP_003900985.1 PREDICTED: signal peptide peptidase-like 2A P. anubis 96.3 456

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: connective tissue; spleen; thyroid; ear; liver; muscle; placenta; mixed; embryonic tissue; stomach; testis; intestine; brain; bone marrow; uncharacterized tissue; adrenal gland; skin; pancreas; mammary gland; larynx; lung; kidney; ovary; heart; vascular; thymus; prostate; parathyroid; trachea; blood; eye; cervix; ascites; lymph; bone; lymph node; uterus; esophagus
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 15
Map position: 15q21.2
UniSTS entry: Chr 15 WI-11902 [Map Viewer]
UniSTS entry: Chr 15 SPPL2A
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

AY169314.1 Homo sapiens intramembrane protease (IMP3) mRNA, complete cds P
AK027446.1 Homo sapiens cDNA FLJ14540 fis, clone NT2RM2001370 P
NM_032802.3 Homo sapiens signal peptide peptidase like 2A (SPPL2A), mRNA P
AK315651.1 Homo sapiens cDNA, FLJ96742, Homo sapiens putative intramembrane cleaving protease (SPPL2A),mRNA P
BC025740.1 Homo sapiens signal peptide peptidase-like 2A, mRNA (cDNA clone MGC:34080 IMAGE:5223715), complete cds PA
AJ420896.1 Homo sapiens mRNA for SPPL2a protein P
AK075454.1 Homo sapiens cDNA PSEC0147 fis, clone PLACE1007190, highly similar to Presenilin-like protein 2 (EC 3.4.99.-) P
AJ345028.1 Homo sapiens mRNA for presenilin-like protein 2 (PSL2 gene) PA

EST sequences (10 of 232) [Show all sequences]

AA970092.1 Clone IMAGE:1581732 mixed 3' read A
AA971002.1 Clone IMAGE:1581941 mixed 3' read
AA988423.1 Clone IMAGE:1594130 kidney 3' read A
BX092463.1 Clone IMAGp998I22187_;_IMAGE:133341 placenta P
R27192.1 Clone IMAGE:133341 placenta 5' read P
R27193.1 Clone IMAGE:133341 placenta 3' read A
CB150494.1 Clone C1SNU17-30-H07 cervix 5' read P
CB145023.1 Clone L11SNU354s1-5-B05 liver 5' read P
CB157290.1 Clone L12JSHC0s1-7-F09 liver 5' read P
AI242134.1 Clone IMAGE:1854444 mixed 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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