> 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HMGCS1)
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UGID:213962     UniGene Hs.397729     Homo sapiens (human)   HMGCS1 Order cDNA clone, Links
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HMGCS1)

Human protein-coding gene HMGCS1. Represented by 524 ESTs from 222 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 213962 - Hs.397729]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003310783.1 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 P. troglodytes 100.0 519
NP_001091742.1 HMGCS1 gene product H. sapiens 100.0 519
XP_001090857.2 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 M. mulatta 99.8 519
XP_003899683.1 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 P. anubis 99.8 519
NP_001184197.1 uncharacterized protein LOC100505431 X. laevis 96.9 519
NP_666054.2 Hmgcs1 gene product M. musculus 96.5 519
NP_957379.1 hmgcs1 gene product D. rerio 85.8 506
NP_524711.1 HMG coenzyme A synthase, isoform A D. melanogaster 73.9 460
XP_957561.1 hydroxymethylglutaryl-CoA synthase N. crassa 63.3 450
NP_192919.1 Hydroxymethylglutaryl-CoA synthase A. thaliana 60.5 451
NP_013580.1 hydroxymethylglutaryl-CoA synthase S. cerevisiae 59.1 443
NP_504496.1 Protein HMGS-1 C. elegans 56.0 277
XP_001695871.1 hypothetical protein CHLREDRAFT_118594 C. reinhardtii 50.0 192
Other hits (2 of 60) [Show all]SpeciesId(%)Len(aa)
NP_001193507.1 HMGCS1 gene product B. taurus 98.5 519
XP_004017060.1 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic O. aries 98.5 519

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; liver; cervix; placenta; prostate; trachea; thymus; skin; mixed; testis; mouth; esophagus; pharynx; lung; uncharacterized tissue; ear; eye; larynx; ovary; mammary gland; uterus; blood; spleen; bone; intestine; kidney; adrenal gland; lymph; pancreas; stomach; connective tissue; ascites; heart; nerve; bladder; vascular; muscle; tonsil; lymph node; thyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5p14-p13
UniSTS entry: Chr 5 RH102927
UniSTS entry: Chr 5 RH80450
UniSTS entry: Chr 5 SHGC-33119
UniSTS entry: Chr 5 RH76109
UniSTS entry: Chr 5 RH99205
UniSTS entry: Chr 5 PMC311006P3
UniSTS entry: Chr 5 HMGCS1
UniSTS entry: Chr 5 RH93594
UniSTS entry: Chr 5 RH98809
UniSTS entry: Chr 5 PMC327197P1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BT007302.1 Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) mRNA, complete cds P
NM_002130.7 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HMGCS1), transcript variant 2, mRNA PA
BC082234.1 Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), mRNA (cDNA clone IMAGE:3677631) A
BC083514.1 Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), mRNA (cDNA clone MGC:90332 IMAGE:4443624), complete cds PA
BC000297.2 Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), mRNA (cDNA clone IMAGE:2819708), partial cds PA
L25798.1 Homo sapiens 3-hydroxy-3-methylglutaryl coenzyme A synthase mRNA, complete cds P
NM_001098272.2 Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HMGCS1), transcript variant 1, mRNA PA
AK315593.1 Homo sapiens cDNA, FLJ96671, Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (HMGCS1), mRNA P
X66435.1 H.sapiens mRNA for HMG-CoA-synthase P
AK095492.1 Homo sapiens cDNA FLJ38173 fis, clone FCBBF1000053, highly similar to HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (EC 4.1.3.5) P
AL050004.1 Homo sapiens mRNA; cDNA DKFZp564P142 (from clone DKFZp564P142) A

EST sequences (10 of 524) [Show all sequences]

R14643.1 Clone IMAGE:35511 brain 5' read
AA976795.1 Clone IMAGE:1586880 uncharacterized tissue 3' read A
AI051937.1 Clone IMAGE:1653438 mixed 3' read A
AI078293.1 Clone IMAGE:1676803 embryonic tissue 3' read A
AI082751.1 Clone IMAGE:1652883 mixed 3' read A
AI125103.1 Clone IMAGE:1577022 spleen 3' read
AI128507.1 Clone IMAGE:1714121 placenta 3' read A
CB069346.1 Clone IMAGE:6364690 pancreas 5' read
BX111411.1 Clone IMAGp998C074196_;_IMAGE:1653438 mixed
AI216760.1 Clone IMAGE:1884523 lung 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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