> FYN oncogene related to SRC, FGR, YES (FYN)
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UGID:208483     UniGene Hs.390567     Homo sapiens (human)   FYN Order cDNA clone, Links
FYN oncogene related to SRC, FGR, YES (FYN)

Human protein-coding gene FYN. Represented by 310 ESTs from 174 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 208483 - Hs.390567]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_036887.1 Fyn gene product R. norvegicus 100.0 536
XP_001368891.1 PREDICTED: tyrosine-protein kinase Fyn isoform 2 M. domestica 100.0 536
XP_001085015.1 PREDICTED: tyrosine-protein kinase Fyn M. mulatta 100.0 536
XP_003898347.1 PREDICTED: tyrosine-protein kinase Fyn isoform 1 P. anubis 100.0 536
XP_001159342.1 PREDICTED: tyrosine-protein kinase Fyn isoform 20 P. troglodytes 100.0 536
NP_002028.1 FYN gene product H. sapiens 100.0 536
XP_854467.1 PREDICTED: tyrosine-protein kinase Fyn isoform 2 C. lupus familiaris 100.0 536
NP_001071440.1 FYN gene product B. taurus 100.0 536
XP_004011245.1 PREDICTED: tyrosine-protein kinase Fyn isoform 1 O. aries 100.0 536
XP_002714971.1 PREDICTED: proto-oncogene tyrosine-protein kinase fyn-like isoform 1 O. cuniculus 100.0 536
NP_001116365.1 Fyn gene product M. musculus 99.8 536
XP_002193297.1 PREDICTED: tyrosine-protein kinase Fyn isoform 1 T. guttata 99.8 536
NP_001073675.2 FYN gene product S. scrofa 99.8 536
XP_003215672.1 PREDICTED: tyrosine-protein kinase Fyn-like isoform 2 A. carolinensis 99.6 536
NP_001079077.1 tyrosine-protein kinase Fyn X. laevis 99.1 536
NP_001025140.1 fynb gene product D. rerio 95.8 543
NP_476849.1 Src oncogene at 42A, isoform A D. melanogaster 67.6 454
NP_490866.4 Protein SRC-1 C. elegans 58.1 530
Other hits (2 of 30) [Show all]SpeciesId(%)Len(aa)
XP_003204338.1 PREDICTED: tyrosine-protein kinase Fyn-like M. gallopavo 99.2 533
XP_002936977.1 PREDICTED: tyrosine-protein kinase Fyn-like isoform 2 X. tropicalis 98.9 536

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; mixed; skin; thyroid; mammary gland; ovary; adipose tissue; placenta; uncharacterized tissue; pituitary gland; mouth; lymph node; larynx; spleen; blood; muscle; liver; cervix; thymus; ear; eye; stomach; uterus; lung; kidney; pancreas; bone; intestine; heart; pharynx; connective tissue; testis; vascular; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6q21
UniSTS entry: Chr 6 GDB:187104
UniSTS entry: Chr 6 RH76192
UniSTS entry: Chr 6 STS-N35086 [Map Viewer]
UniSTS entry: Chr 6 RH48180
UniSTS entry: Chr 1 L17971
UniSTS entry: Chr 1 L18441
UniSTS entry: Chr 1 GDB:314481
UniSTS entry: Chr 1 D10S2448
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

M14676.1 Human src-like kinase (slk) mRNA, complete cds P
BX537571.1 Homo sapiens mRNA; cDNA DKFZp686E249 (from clone DKFZp686E249) P
NM_002037.5 Homo sapiens FYN oncogene related to SRC, FGR, YES (FYN), transcript variant 1, mRNA P
AY429536.1 Homo sapiens FYNv_2 mRNA sequence; alternatively spliced
M14333.1 Homo sapiens c-syn protooncogene mRNA, complete cds P
AK056699.1 Homo sapiens cDNA FLJ32137 fis, clone PEBLM2000479, highly similar to Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) P
BC032496.1 Homo sapiens FYN oncogene related to SRC, FGR, YES, mRNA (cDNA clone MGC:45350 IMAGE:5219761), complete cds PA
AB451426.1 Homo sapiens FYN mRNA for protein-tyrosine kinase fyn isoform a, partial cds, clone: FLJ08138AAAF P
AB451293.1 Homo sapiens FYN mRNA for protein-tyrosine kinase fyn isoform a, complete cds, clone: FLJ08138AAAN P
NM_153048.3 Homo sapiens FYN oncogene related to SRC, FGR, YES (FYN), transcript variant 3, mRNA P
NM_153047.3 Homo sapiens FYN oncogene related to SRC, FGR, YES (FYN), transcript variant 2, mRNA P
S74774.1 p59fyn(T)=OKT3-induced calcium influx regulator [human, Jurkat J6 T cell line, mRNA Partial, 1605 nt] P

EST sequences (10 of 310) [Show all sequences]

R14273.1 Clone IMAGE:28442 brain 5' read
AA962845.1 Clone IMAGE:1573767 kidney 3' read A
AA969972.1 Clone IMAGE:1581241 mixed 3' read A
AA995101.1 Clone IMAGE:1625802 mixed 3' read A
AI005024.1 Clone IMAGE:1635166 kidney 3' read P
AI125034.1 Clone IMAGE:1726223 vascular 3' read
AI147755.1 Clone IMAGE:1703302 brain 3' read P
AI150708.1 Clone IMAGE:1706115 heart 3' read
AI160073.1 Clone IMAGE:1708989 heart 3' read
AI187118.1 Clone IMAGE:1741668 lung 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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